HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

Thakkar, Himani; Vincent, Vinnyfred; Roy, Ambuj; Singh, Sandeep; Kalaivani, Mani; Singh, Archna

doi:10.1186/s12944-020-01260-4

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…More recently, a case-control study analyzed 150 patients with acute coronary syndrome (ACS) and 110 healthy adults not presenting clinical CVD and not undergoing any lipid-lowering therapy. In ACS patients, HDL CEC was found to be reduced compared to controls and associated with higher odds of ACS presence, even after adjustment for confounding factors including plasma HDL-C levels [ 64 ]. Interestingly, after 6 months of standard therapy, HDL CEC was restored in ACS patients, further pointing to this functional parameter as a good candidate for CVD risk prediction.…”

Section: Hdl Cec Atherosclerosis and Cardiovascular Riskmentioning

confidence: 99%

High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

Adorni

Ronda

Bernini

et al. 2021

Cells

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Over the years, the relationship between high-density lipoprotein (HDL) and atherosclerosis, initially highlighted by the Framingham study, has been revealed to be extremely complex, due to the multiple HDL functions involved in atheroprotection. Among them, HDL cholesterol efflux capacity (CEC), the ability of HDL to promote cell cholesterol efflux from cells, has emerged as a better predictor of cardiovascular (CV) risk compared to merely plasma HDL-cholesterol (HDL-C) levels. HDL CEC is impaired in many genetic and pathological conditions associated to high CV risk such as dyslipidemia, chronic kidney disease, diabetes, inflammatory and autoimmune diseases, endocrine disorders, etc. The present review describes the current knowledge on HDL CEC modifications in these conditions, focusing on the most recent human studies and on genetic and pathophysiologic aspects. In addition, the most relevant strategies possibly modulating HDL CEC, including lifestyle modifications, as well as nutraceutical and pharmacological interventions, will be discussed. The objective of this review is to help understanding whether, from the current evidence, HDL CEC may be considered as a valid biomarker of CV risk and a potential pharmacological target for novel therapeutic approaches.

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Section: Hdl Cec Atherosclerosis and Cardiovascular Riskmentioning

confidence: 99%

High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

Adorni

Ronda

Bernini

et al. 2021

Cells

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“…HDL's capacity to promote cholesterol efflux from macrophages is known to have a strong negative association with the incidence of CVD independent of HDL-C levels [ 19 ], and we have previously demonstrated that low CEC is associated with higher odds of having acute coronary syndrome [ 14 ]. We observed a lower CEC in individuals with obesity than control subjects in concordance with other published studies [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…The assay was performed according to a previously described protocol [ 10 , 14 , 15 ]. The serum samples were treated with 20% polyethylene glycol as the precipitating reagent to isolate apo B depleted serum.…”

Section: Methodsmentioning

confidence: 99%

Improvements in cholesterol efflux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatric surgery in a cohort with morbid obesity

Thakkar

Vincent

Shukla

et al. 2021

Diabetol Metab Syndr

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Background Bariatric surgery can alleviate cardiovascular risk via effects on cardiovascular disease (CVD) risk factors such as diabetes mellitus, hypertension, and dyslipidemia. Our study aimed to assess the cholesterol efflux capacity (CEC) of HDL as a negative risk factor for CVD in individuals with obesity and identify the factors associated with improvement in CEC 3 months following bariatric surgery. Methods We recruited 40 control individuals (mean BMI of 22.2 kg/m2) and 56 obese individuals (mean BMI of 45.9 kg/m2). The biochemical parameters, inflammatory status and CEC of HDL was measured for the obese individuals before bariatric surgery and at 3 months after surgery. The CEC was measured using a cell-based cholesterol efflux system of BODIPY-cholesterol-labelled THP-1 macrophages. Results A significant reduction in BMI (− 17%, p < 0.001), resolution of insulin sensitivity (HOMA2-IR = − 23.4%, p = 0.002; Adipo IR = − 16%, p = 0.009) and inflammation [log resistin = − 6%, p = 0.07] were observed 3 months post-surgery. CEC significantly improved 3 months after surgery [Pre: 0.91 ± 0.13; Post: 1.02 ± 0.16; p = 0.001] despite a decrease in HDL-C levels. The change in CEC correlated with the change in apo A-I (r = 0.39, p = 0.02) and adiponectin levels (r = 0.35, p = 0.03). Conclusion The results suggest that improvements in CEC, through improvement in adipose tissue health in terms of adipokine secretion and insulin sensitivity could be an important pathway in modulating obesity-related CVD risk.

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“…43 Indeed, the role of HDL-c in the removal of fats and cholesterol from cells within the artery wall atheroma, and the transportation of lipids to the liver for excretion or re-utilization has been linked to acute coronary syndrome. 44 Elevated TG and T. chol levels, on the other hand, have been associated with increased risk of cardiovascular disease, 45 and the increase in risk may be attributed to lipids deposition and arterial obstruction to blood flow.…”

Section: Discussionmentioning

confidence: 99%

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

Tagoe

Dwamena-Akoto

Nsaful

et al. 2020

Exp Biol Med (Maywood)

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Comorbidities impact negatively on breast cancer prognosis, especially in developing countries where cases are usually presented to clinics at advanced stages. This study aimed to determine the atherogenic index of plasma (AIP) and cardiovascular risk factors among Ghanaian women diagnosed with breast cancer. A total of 52 breast cancer patients were age-matched with 52 healthy controls. Sociodemographics of participants were obtained using a well-structured questionnaire. Pathological data of patients were obtained from medical records, and all clinical and anthropometric measurements were done using standard instruments. Lipid profile was determined from serum using enzymatic assays, and cardiovascular risk factors were calculated from estimated lipid parameters. Blood pressure, AIP, total cholesterol (T. chol), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) were significantly elevated ( P < 0.05) in the breast cancer patients compared to the controls, but the reverse was observed for high-density lipoprotein cholesterol (HDL-c) ( P < 0.01). Obesity (odds ratio [OR] = 2.51, P = 0.015), hypertension (OR = 4.04, P < 0.001), AIP (OR = 10.44, P < 0.001), and dyslipidemia ( P < 0.01) were significantly associated with breast cancer. AIP correlated positively with age (r = 0.244, P < 0.05), body mass index (r = 0.225, P < 0.05), blood pressure ( P < 0.01), T. chol (r =0.418, P< 0.01), and TG (r = 0.880, P < 0.01), but inversely correlated with HDL-c (r = −0.460, P < 0.01). A greater proportion (88%) of the patients presented with advanced breast cancer. AIP and cardiovascular risk factors were high in the breast cancer patients. Considering that AIP and cardiovascular disease risk factors are of interest in breast cancer patients, further studies are needed to understand the effect of AIP and cardiovascular risk factors on breast cancer outcomes. Impact statement Breast cancer prognosis is negatively impacted by comorbidities, especially in global regions where patients present to clinics with advanced cancer stages. This study reports preliminary findings on atherogenic index of plasma (AIP) and cardiovascular risk factors in Ghanaian breast cancer patients. AIP and cardiovascular risk factors were identified to be high in the breast cancer patients and therefore should be of prime interest to warrant further studies. Ultimately, understanding the contribution of AIP and cardiovascular risk factors in breast cancer will impact positively on clinical management of patients with breast cancer.

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HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

Cited by 15 publications

References 28 publications

High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

Improvements in cholesterol efflux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatric surgery in a cohort with morbid obesity

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

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