Head and Neck Atopic Dermatitis and <i>Malassezia-furfur</i>-Specific IgE Antibodies

Abstract

Background: Atopic dermatitis of the head and neck (HNAD) has been recognized as a separate entity. Malassezia furfur, a lipophilic yeast, is considered to be a pathogenic allergen in this form of atopic dermatitis. Objective: The purpose of this study was to determine the level of IgE anti-M.-furfur antibodies and their relation to the severity of the disease. Methods: IgE anti-M.-furfur antibodies were assayed in 106 patients with HNAD. Controls included 25 patients with non-HNAD, 20 with nonatopic dermatitis and 16 with seborrheic dermatitis (including 4 with AIDS). Results: There was a highly significant correlation between the level of anti-M.-furfur IgE and clinical severity. Furthermore, there was a significant but smaller correlation between total IgE and clinical severity. In patients with HNAD, total IgE was higher amongst men. Conclusion: IgE anti-M.-furfur antibodies are a good and specific marker for HNAD. IgE M. furfur levels are strongly correlated with the severity of the disease.

Cutaneous <i>Malassezia</i> Microbiota in Atopic Dermatitis Patients Differ by Gender and Body Part

“…This hypothesis has been supported by the report that AD patients have positive reactions to Malassezia yeasts in patch tests [4]. In addition, specific Malassezia IgE antibodies were found in AD patients but not in healthy individuals [5,6,7,8,9,10]. …”

The role of Malassezia in atopic dermatitis affecting the head and neck of adults

“…11,[13][14][15][16][17][18][19] Focusing on the subset of patients with HND, research has shown that these patients tend to have higher rates of positive SPT results and higher levels of Malassezia-specific IgE when compared with patients who have AD without HND. 13,17,[19][20][21][22][23][24][25] The most favorable study enrolled 589 patients and found that 100% of patients with HND had increased Malassezia-specific IgE compared with only 13% of patients with AD without HND. 23 Two studies have even reported a correlation between Malassezia-specific IgE levels and the clinical severity of HND.…”

Atopik Dermatitli Hastalarda Malassezia Yükünün Moleküler Yöntemler ile Gösterilmesi

“…3,4 Deri yüzeyindeki Malassezia kolonizasyonunun gösterilmesi için çeşit- li yöntemler geliştirilmiştir. 8,9 Bu yöntemlerden en etkili olanı yapışkan film kullanarak deri yüzeyinden örnek alınması ve filmin yüzeyine yapışan Malassezia hücrelerinin kantitatif olarak sayılmasıdır. 10 AD'li hastaların deri örneklerinde Malassezia kolonizasyonunun kantitatif olarak gösterilmesi için, örnek alınmasından başlayarak, DNA eldesi, DNA çoğaltılma basamağı olmak üzere bütün aşamalarda kalite kontrolüne dikkat edilmiştir.…”

“…AD hastalarında diğer mantarlardan çok daha fazla Malassezia için gelişmiş Tip 1 aşırı duyarlık tablosu bulunmaktadır. 8,9 AD patogenezi karmaşık bağışıklık mekanizmalarını içermekte olup, tam olarak anlaşılabilmiş değildir. Sugita ve ark.…”