Head and Neck Squamous Cell Carcinoma in Iran: Clinico-Pathological and Treatment-Related Factors Influencing Survival

Novin, Kambiz; Alipour, Ahmad; Faraji, Saba; Torbati, Peyman Mohammadi; Mortazavi, Nafiseh

doi:10.17795/ijcp-3842

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…In current study, all of the patients are men. We found patients with total laryngectomy, poor differentiation, T3-T4 stage, N1-N2 stage, III-IV TNM stage had a worse prognostic survival and these findings are consistent with results of most other studies 11-14 . We also showed that the polymorphisms of rs11903757 near NABP1 gene and rs966423 in DIRC3 gene correlate with prognostic survival in patients with SLCC.…”

Section: Discussionsupporting

confidence: 92%

DIRC3and close toNABP1Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell Carcinoma

Shen

Ren

Bai

et al. 2016

Preprint

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Laryngeal squamous cell carcinoma (LSCC) is one of the most common and aggressive malignancies in the upper digestive tract that has a high mortality rate and a poor prognosis. Prognostic factors were determined through multivariate Cox regression analysis. The overall survival rates were calculated by the Kaplan-Meier method. The SPSS statistical software package version 17.0 (SPSS Inc., Chicago, IL, USA) was used for all analyses. Median follow-up was 38 (range 3-122) months and the median survival time was 48 months. We adjusted to confounding factors (total laryngectomy, poor differentiation, T3-T4 stage, N1-N2 stage, III-IV TNM stage) into multivariate Cox proportional hazards model, we confirmed rs11903757 GT genotype (HR = 2.036; 95% CI, 1.071 -3.872; p = 0.030) and rs966423 TT genotype (HR = 11.677; 95% CI, 3.901 -34.950; p = 0.000) were significantly correlated with prognostic survival of patients with LSCC compared with rs11903757 TT genotype and rs966423 CC genotype, respectively. Our research provided new evidence for patients with LSCC, it seemed to be the first that demonstrated rs11903757 GT genotype on chromosome 2q32.3 close to NABP1 and rs966423 TT genotype in the intron region of DIRC3 on chromosome 2q35 predict poor prognostic survival in patients with LSCC.Keywords: DIRC3, LSCC, NABP1, overall survival, prognostic factors LSCC 3-5 . Despite significant advances in surgery and radio therapeutic techniques, as well as the attempt to use new chemotherapy drugs, the 5-year relative survival rates for patients with LSCC have not markedly improved. The mortality rate of LSCC is still high with 1.2 cases per 100,000 persons 6 . Although great progress has been achieved in the study on laryngeal cancer, there are no ideal biomarkers for the determination of prognosis and guidance of treatment in laryngeal cancer patients.Presently, much work is focused on the identification of useful biologic and molecular markers in the diagnosis and therapy of LSCC 7, 8 . In recent years, scholars have proposed that the combined expression of multiple genes may serve as a satisfactory marker for prognostic prediction. As tissue microarray technology and proteomics develop, more and more metastasis suppressor genes have been found. Exploring relations among anti-metastasis genes plays an important part in the prognostic prediction and treatment of LSCC. Therefore, it is imperative to find novel molecular markers underlying the tumorigenesis of LSCC for early diagnosis and prognostic assessment.We undertook a retrospective analysis of data from a prospective longitudinal study of 170 patients over an extended time period (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013) to examine the epidemiology of laryngeal squamous cell carcinoma (LSCC) with regard to age, laryngectomy, neck dissection, tumor differentiation, T-stage, N-stage, TNM stage and treatment modality.Meanwhile, in analyzing possible genetic polymorphisms associated with the susceptibility and prognostic evaluation of SLCC, we hoped...

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Section: Discussionsupporting

confidence: 92%

DIRC3and close toNABP1Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell Carcinoma

Shen

Ren

Bai

et al. 2016

Preprint

View full text Add to dashboard Cite

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“…All patients in the current study were men. Consistent with other studies, we found that patients with total laryngectomy, poor differentiation, T3–T4 stage, N1–N2 stage or III–IV TNM stage had reduced survival [ 9 – 12 ]. We developed multivariate Cox regression analysis models that adjusted for the most important covariates, including SNP, tumor differentiation, neck dissection, T stage and TNM stage.…”

Section: Discussionsupporting

confidence: 91%

“…In some researches indicated that patients T-stage and N-stage had demonstrated to be significantly associated with survival and these findings are consistent with results of most other studies. Our study also obtained the consistent conclusion [ 9 , 13 , 14 ]. A multivariate analysis was conducted, taking the variables found to be significant in univariate analyses ( p ≤0.2) into account.…”

Section: Discussionsupporting

confidence: 90%

DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival

et al. 2016

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Laryngeal squamous cell carcinoma (LSCC) is one of the most common and aggressive malignancies of the upper digestive tract. The present study is a retrospective analysis of data from a prospective longitudinal study. A total of 170 male LSCC patients (average age, 60.75±10.082) at the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine were recruited between January 2002 and April 2013 for this study. We assessed correlations between patient characteristics and survival, and sequenced genomic DNA from patient peripheral blood samples. We found that the single nucleotide polymorphisms (SNPs), rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were associated with survival in LSCC patients. Median follow-up was 38 months (range 3–122) and median survival time was 48 months. LSCC patients with total laryngectomy, poor differentiation, T3-T4 stage, N1-N2 stage or III-IV TNM stage had reduced survival. This is the first study to demonstrate that the rs11903757 GT (HR=2.036; 95% CI, 1.071–3.872; p=0.030) and rs966423 TT (HR=11.677; 95% CI, 3.901–34.950; p=0.000) genotypes predict poor patient outcome. These polymorphisms may serve as useful clinical markers to predict patient survival, and to guide individual patient therapeutic decisions.

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“…Also the results of other studies are consistent with the present study (6,17,18,(20)(21)(22)(23). One possible explanation for the higher incidence of oral cancer in men can be higher consumption of tobacco and alcoholic products.…”

Section: Sexsupporting

confidence: 92%

The Epidemiological Pattern of Premalignant and Malignant Epithelial Lesions in Northeast of Iran: A 43-Year Evaluation

Saghravanian

Mohtasham

Ivani³

et al. 2017

Int J Cancer Manag

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Background: Cancer is one of the most common causes of death in human society. Epidemiological information has an important role in planning for prevention, diagnosis and treatment of cancer in communities. Objectives: The aim of this study was to evaluate epidemiological aspects of the premalignant and malignant epithelial lesions during a 43-year period in faculty of dentistry, Mashhad University of Medical Sciences, Iran. Methods: In this retrospective-descriptive study, all archived records in oral pathology department of dental school, Mashhad University of Medical Sciences in northeast of Iran, during the period of 1971 -2013 were investigated. A total of 11126 pathology reports were evaluated. Age, gender, primary site and histologic type of the lesions were extracted from patient's records. Data were analyzed using SPSS statistical software (V. 21), Chi-square, Fisher's exact and Mann-Whitney tests.

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Head and Neck Squamous Cell Carcinoma in Iran: Clinico-Pathological and Treatment-Related Factors Influencing Survival

Cited by 8 publications

References 21 publications

DIRC3and close toNABP1Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell Carcinoma

DIRC3and close toNABP1Genetics Polymorphisms correlated with Prognostic Survival in Patients with Laryngeal Squamous Cell Carcinoma

DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival

The Epidemiological Pattern of Premalignant and Malignant Epithelial Lesions in Northeast of Iran: A 43-Year Evaluation

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