Head and Tail Entity Fusion Model in Medical Knowledge Graph Construction: Case Study for Pituitary Adenoma (Preprint)

Abstract

BACKGROUND Pituitary adenoma is one of the most common central nervous system tumors. The diagnosis and treatment of pituitary adenoma are still very difficult. Misdiagnosis and recurrence occur from time to time, and experienced neurosurgeons are in serious shortage. Knowledge graphs can help interns quickly understand the medical knowledge related to pituitary tumor. OBJECTIVE The aim of this paper is to integrate the data of pituitary adenomas from reliable sources and construct a knowledge graph, and use the knowledge graph for knowledge discovery. METHODS A method of constructing a knowledge graph of diseases was introduced and used to build a knowledge graph for pituitary adenoma (KGPA). The schema of the KGPA was manually constructed. Information of pituitary adenoma were automatically extracted from EMR and the medical websites through the CRF model and web wrappers we designed. An entity fusion method was proposed, based on the head and tail entity fusion models, to fuse the data from heterogeneous sources. The disease entities were standardized to ICD-10. RESULTS Data was extracted from 300 EMRs of pituitary adenoma and 4 medical portals. Entity fusion was carried out by using the data fusion model we proposed. The accuracy of the head and tail entity fusion were more than 97%. Part of the triples were selected for evaluation, and the accuracy was 95.4%. CONCLUSIONS This paper introduced an approach to construct KGPA and proposed a data fusion method suitable for medical data. The evaluation results show that the data in KGPA is of high quality. The constructed KGPA can help physicians in their clinical practice.