Objectives: Little information is available on long-term headache following head injury. We compared the prevalence of headache in a cohort with previous hospitalization for head injury and matched controls. Materials and Methods: A questionnaire about headache was sent to 361 patients who were hospitalized for head injury in 1974–1975 and 722 matched community controls. Results: In multivariate conditional regression analysis among 192 responding case/control pairs, there was no evidence of higher odds of headache ≥1 day per month (odds ratio, OR 1.04, 95% CI 0.56–1.92, p = 0.90) compared with controls. However, there was a tendency to higher odds of headache ≥1 day per month among female cases than among controls (OR 2.03, 95% CI 0.94–4.39, p = 0.07). Conclusions: The study could not show increased odds of headache in a cohort 22 years following hospitalization for head injury, but it is possible that females are more likely to report long-term headache following head injury than matched controls.