Healing activity evaluation of the galactomannan film obtained from Cassia grandis seeds with immobilized Cratylia mollis seed lectin

Albuquerque, Priscilla Barbosa Sales de; Soares, Paulo R.; Aragão-Neto, Adelmo C.; Albuquerque, Giwellington Silva; Silva, Luís C. N.; Lima-Ribeiro, Maria Helena Madruga; Neto, Jacinto da Costa Silva; Coelho, Luana Cassandra Breitenbach Barroso; Correia, Maria T.S.; Teixeira, J. A.; Carneiro-da-Cunha, Maria G.

doi:10.1016/j.ijbiomac.2017.04.064

Cited by 29 publications

(10 citation statements)

References 42 publications

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“…C. mollis is an endemic plant of Caatinga (Brazil semi-arid area), a plant from the Brazilian exclusive biome. pCramoll is a mannose-specific lectin and it has shown several biotechnological applications, including induction of cell proliferation ( Maciel et al, 2004 ; da Silva et al, 2015a ), in vitro immunomodulation ( de Melo et al, 2010 ; da Silva et al, 2015b ), wound healing ( Albuquerque et al, 2017 ), and anticancer properties ( da Cunha et al, 2016 ). Particularly, the immunomodulatory ability of pCramoll has been demonstrated in an in vivo model of wound healing in immunocompromised mice ( de Oliveira Silva et al, 2011 ) and in experimental infection with Schistosoma mansoni ( de Oliveira Silva et al, 2011 ).…”

Section: Plant Lectins For Treatment Of Fungal Infectionsmentioning

confidence: 99%

Targeting the Immune System with Plant Lectins to Combat Microbial Infections

et al. 2017

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The arsenal of drugs available to treat infections caused by eukaryotic and prokaryotic microbes has been declining exponentially due to antimicrobial resistance phenomenon, leading to an urgent need to develop new therapeutic strategies. Host-directed immunotherapy has been reported as an attractive option to treat microbial infections. It consists in the improvement of host defenses by increasing the expression of inflammatory mediators and/or controlling of inflammation-induced tissue injury. Although the in vitro antimicrobial and immunomodulatory activities of lectins have been extensively demonstrated, few studies have evaluated their in vivo effects on experimental models of infections. This review aims to highlight the experimental use of immunomodulatory plant lectins to improve the host immune response against microbial infections. Lectins have been used in vivo both prophylactically and therapeutically resulting in the increased survival of mice under microbial challenge. Other studies successfully demonstrated that lectins could be used in combination with parasite antigens in order to induce a more efficient immunization. Therefore, these plant lectins represent new candidates for management of microbial infections. Furthermore, immunotherapeutic studies have improved our knowledge about the mechanisms involved in host–pathogen interactions, and may also help in the discovery of new drug targets.

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Section: Plant Lectins For Treatment Of Fungal Infectionsmentioning

confidence: 99%

Targeting the Immune System with Plant Lectins to Combat Microbial Infections

et al. 2017

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“…The usage of fibroblast cell lines to assess the toxicity of nanofibrous mats is an appreciable factor in characterizing the potential of wound dressings for biological applications. 19 The HDF proliferation assay on nanofibers revealed enhanced proliferation of cells on PB5Ai nanofibrous mats by about 20% from day 3 to day 6 relative to PB nanofibers as depicted in Figure 8…”

Section: Hdf Proliferation Assaymentioning

confidence: 96%

Fabricated approach for an effective wound dressing material based on a natural gum impregnated with Acalypha indica extract

Jenifer

Kalachaveedu

Viswanathan

et al. 2018

Journal of Bioactive and Compatible Polymers

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Although acute wounds are common, treatment for a scarless condition remains limited and ineffective as medicated dressings act only as an epidermal coverage and no interdermal interactions happen. This study examined the benefit of Acalypha indica, a traditionally acclaimed plant for wound healing, as a three-dimensional nanofibrous dressing. guar gum, a natural polysaccharide, was chosen as the raw material, in combination with a synthetic copolymer polyvinyl alcohol. A series of polymer blend nanofibers made of 3:7 of 1% wt guar and 10% wt polyvinyl alcohol along with varied ratios of A. indica were prepared using electrospinning. The effect of cross-linking by citric acid on the nanofibers was studied using Fourier transform infrared. A 5% wt A. indica content was optimized in the electrospun solution to get nanosized morphology, roughness, water absorbing capacity, thermal stability, and tensile strength. The composite material was found inhibitory to both Gram-positive and Gram-negative strains as measured by zone of inhibition. The ability of the dressing to support and proliferate human dermal fibroblasts was evaluated by cell proliferation assay and Calcein acetomethyl (AM) staining assay. The results confirmed that the composite dressing could support long-term cell growth in the 9-day cell culture study. The incorporation

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“…Film is a transparent, semi-permeable membrane dressing, which is impermeable to liquid and bacteria contamination from outside, but permeable to water vapor, carbon dioxide and oxygen [71,81,87]. It creates a moist environment in conjunction with a small amount of exudate what provides removal of necrotic tissue and enables a cellular migration to promote wound healing [80].…”

Section: Filmsmentioning

confidence: 99%

Methods of extraction, physicochemical properties of alginates and their applications in biomedical field – a review

2019

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In this paper, the current state-of-art of extraction of alginates and the determination of their physico-chemical properties as well as their overall applications focussing on biomedical purposes has been presented. The quality and quantity of the alginate obtained with a variable yield prepared from brown seaweeds as a result of many factors, such as type of algae, extraction methods, chemical modification and others. Alginates are mainly extracted by using conventional alkaline extraction. However, novel extraction techniques such as microwave and ultrasound assisted extractions have gained a lot of interest. The extraction parameters (e.g., temperature and time of extraction) have critical impact on the alginate physiochemical and mechanical properties and thus, their potential applications. By controlling a chemical process makes it possible get various forms of alginates, such as fibres, films, hydrogels or foams. It is important to characterise the obtained alginates in order to their proper applications. This article presents several techniques used for the analysis of alginate properties. These natural polysaccharides are widely used in the commercial production, as a food ingredient, in the pharmaceutical industry due to their antibacterial, anticancer and probiotic properties. Their gelling characteristic and absorbable properties enable using alginates as a wound management material. Moreover, they are also biocompatible, non-toxic and biodegradable, therefore adequate in other biomedical applications.

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Healing activity evaluation of the galactomannan film obtained from Cassia grandis seeds with immobilized Cratylia mollis seed lectin

Cited by 29 publications

References 42 publications

Targeting the Immune System with Plant Lectins to Combat Microbial Infections

Targeting the Immune System with Plant Lectins to Combat Microbial Infections

Fabricated approach for an effective wound dressing material based on a natural gum impregnated with Acalypha indica extract

Methods of extraction, physicochemical properties of alginates and their applications in biomedical field – a review

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