Healing an intractable wound using bio-electrical stimulation therapy

Hampton, Sylvie; King, Lynn

doi:10.12968/bjon.2005.14.sup3.18608

Cited by 24 publications

(25 citation statements)

References 4 publications

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“…[54][55][56][57][58] Eleven clinical reports including several uncontrolled prospective cohort studies 59,60,65,66,72,74,77,78,80,[86][87][88]91 and retrospective analyses 78 showed that the application of EST to a variety of wound types consistently improved healing outcomes. Altogether, this body of literature provides strong support that EST stimulates generic processes of tissue repair and so is effective on many different types of chronic or recalcitrant wounds.…”

Section: Houghtonmentioning

confidence: 99%

“…33,37,39,43,50,51,56,57 A couple of studies reported only the number of wounds 37,64 treated, and some included results from multiple wounds from the same patient. 33,39,42,49,57,65,66 EST was delivered in a variety of ways to tissues surrounding the wound, or directly into the wound bed or both. Most devices used to deliver EST provided pulsed current via small battery-operated devices.…”

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confidence: 99%

“…Several reports document the benefits and safe application of EST on specific cases with very challenging wounds 6,[64][65][66][67][68][69][70][71][72][73][74][75][76][77] and other noncontrolled retrospective 78,79 and prospective research designs. [80][81][82][83][84][85] Two of the original clinical reports are often identified as controlled studies since they included a relatively large number of subjects; however, they compared healing outcomes produced after EST to only six patients with bilateral wounds.…”

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confidence: 99%

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Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Houghton¹

2017

CWCMR

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Purpose:The overall objective of this study is to identify and appraise all of the existing clinical research literature that has evaluated the effect of electrical stimulation therapy (EST) on wound healing outcomes in adults with various types of chronic wounds. Methods: A systematic and comprehensive search of four electronic databases and gray literature was carried out, and references included in related review articles were checked. Prospective and controlled clinical trials, systematic reviews (SRs), and meta-analyses that assessed the effects of EST on wound healing outcomes were described and appraised. A total PRISMA score was assigned for each included SR based on criteria included in the assessment of multiple systematic reviews (AMSTAR) measurement tool. The percentage of available research that was identified in the SR was also calculated. Results: Sixty-two clinical research studies involving 2082 patients with pressure ulcers, venous leg ulcers, diabetic foot wounds, and arterial/ischemic wounds, and ulcers of mixed etiology were located. Thirty-three of the studies with 1370 patients compared wound size reduction after EST to a control group. Eighteen reviews that used a systematic approach to identify, select, and evaluate published studies on this topic have yielded conflicting results. Poorer quality SRs with a low total PRISMA score were more likely to yield negative or inconclusive findings. Most of these low-quality SRs had very vague research questions and included less than 50% of the available literature that was known to exist. Results from 22 well-designed randomized clinical trials and 10 high-quality SRs consistently support that EST can stimulate faster wound size reduction and/or produce a greater number of closed wounds compared to a group of similar patients receiving either standard wound care or sham EST. Conclusion: Pooled results from well-conducted SRs provide strong support for the use of EST on various types of chronic wounds and pressure ulcers in particular.

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Section: Houghtonmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Houghton¹

2017

CWCMR

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“…In actuality, following tissue damage, an injury current is generated that is thought to trigger biological repair [14,[18][19]. Based on these finding, researchers have proposed that external ES may help healing through the simulation and enhancement of natural bioelectric currents [3,13,[19][20]. This theory is considered one of the most important mechanisms of the effectiveness of ES on wound healing [1,3].…”

Section: Introductionmentioning

confidence: 99%

Effect of anodal and cathodal microamperage direct current electrical stimulation on injury potential and wound size in guinea pigs

Talebi

Torkaman²,

Firoozabadi³

et al. 2008

JRRD

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Abstract-Injury potential may have a regulatory role in the wound healing process, and exogenous electrical stimulation (ES) may mimic natural endogenous bioelectric current that can improve wound healing. Until now, the influence of externally applied ES on injury potential has not been demonstrated during the healing of acute wounds. Thirty-nine male guinea pigs were randomly divided into a control group (sham treatment) and two experimental groups: anodal and cathodal direct current (DC). A 2.5 cm-long full-thickness skin incision was made on each animal's dorsal region. Differential skin surface potential was measured before and immediately after the injury and also through day 21 of the healing period; wound surface area (WSA) was also measured throughout the 21-day healing period. Immediately after injury, wound potential significantly increased in all three groups, reaching a maximum on day 1 for the control and cathodal groups and day 3 for the anodal group (p < 0.05), then decreasing through the healing period. Wound potential returned to preinjury levels by the end of the healing period in the anodal group only. By days 19 and 21, wound potential had decreased more for the anodal group than the control group (p < 0.05). By day 15 for the anodal group and day 17 for the cathodal group, WSA had decreased more compared with the control group (p < 0.05). Anodal microamperage DC ES is appropriate for improving the healing of acute skin wounds because it causes both the wound surface to close and the wound potential to return to preinjury levels faster.

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“…Vodovnik and Karba [19], Hampton and King [20], and Nuccitelli [21] suggested that the endogenous bioelectric current of the wound has a regulatory role in the wound-healing process and that the use of exogenous electrical stimulation may mimic this endogenous current and improve wound healing.…”

Section: Introductionmentioning

confidence: 99%

Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

Mehmandoust¹,

Torkaman²,

Firoozabadi³

et al. 2007

JRRD

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Abstract-We investigated the effects of anodal and cathodal electrical stimulation on wound healing. In a randomized controlled trial, we divided 42 male albino guinea pigs into two control (C1 and C2) and four experimental (E1-E4) groups. A 3 cm linear incision was made at the dorsal skin of all guinea pigs. A unidirectional pulse current of 300 to 600 microamperes, 80 pps, and 0.3 ms pulse duration was administered for 1 hour a day. In groups E1 and E3 (anodal), a positive polarity was applied for the first 3 days followed by negative polarity the remaining days. In groups E2 and E4 (cathodal), negative polarity was applied for the first 3 days and positive polarity the remaining days. Groups E1, E2, and C1 were killed on day 14 and E3, E4, and C2 on day 21. We measured the percentage of decrease in wound surface area (daily tracing) and tensile strength (on days 14 and 21). The results indicated that both cathodal and anodal stimulations increased the rate of wound closure. Beginning with day 12, we saw a significant difference in the percentage of the decrease in wound surface between all treatment and control groups (p < 0.05). Ultimate tensile strength and stress increased in the anodal compared with the cathodal and control groups; at the end of day 14, ultimate tensile stress in E1 was significantly greater compared with C1 (p < 0.05). We conclude that electrical stimulation, regardless of polarity regimen, benefits wound healing, but anodal stimulation the first 3 days and cathodal stimulation the remaining days can lead to stronger repaired tissue.

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Healing an intractable wound using bio-electrical stimulation therapy

Cited by 24 publications

References 4 publications

Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Effect of anodal and cathodal microamperage direct current electrical stimulation on injury potential and wound size in guinea pigs

Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

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