Healing Impairment of Open Wounds by Skin Irradiation

Bernstein, Eric F.; Harisiadis, Leon; Salomon, Gary D.; MITCHELL, FRANK HARRINGTON JAMES B.; Uitto, Jouni; Glatstein, Eli; Russo, Angelo

doi:10.1111/j.1524-4725.1994.tb03200.x

Cited by 33 publications

(27 citation statements)

References 21 publications

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“…Results obtained from previous studies have demonstrated that prior irradiation with x-ray doses of 20 Gy caused a significant delay in the rate of wound healing by day 7 when compared with the non-x-ray-irradiated control [18,30]; Bernstein et al [29] also reported similar findings. The impaired wound-healing model used in the present study showed a significantly extended proliferative phase during the wound-healing process, whereas at the inflammatory and remodelling phases this delay was not found to be significant.…”

Section: Discussionsupporting

confidence: 75%

“…Additionally, to stimulate pathologic wounds similar to those found clinically (e.g., in elderly and diabetic patients), an impaired wound-healing model is necessary. Such an impaired wound-healing model can be induced through x-ray irradiation; although its effect has been found to be dose-dependent [27], it has been reported recently that x-ray irradiation of a single 20-Gy dose to the skin delays wound healing by 7 days [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

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Effect of low-intensity laser irradiation (660 nm) on a radiation-impaired wound-healing model in murine skin

et al. 2000

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Effect of low-intensity laser irradiation (660 nm) on a radiation-impaired wound-healing model in murine skin

et al. 2000

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“…It stimulates collagen and proteoglycan synthesis. pDGF is involved in all stages of wound healing and influences the growth and the function of various mesenchymal cells (60).…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

Radiotherapy and wound healing: Principles, management and prospects (Review)

Gieringer

Gosepath²,

Naim³

2011

Oncol Rep

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Abstract. radiation therapy is a major therapeutic modality in the management of cancer patients. Over 60% of these patients receive radiotherapy at some point during their course of treatment and over 90% will develop skin reactions after therapy. problematic wound healing in radiation-damaged tissue constitutes a major surgical difficulty and despite all efforts, irradiated skin remains a therapeutic challenge. this review provides an overview of the fundamental principles of radiation therapy with regards to the wound healing in normal and irradiated skin. Furthermore, it presents techniques that describe how to prevent and manage skin side effects as well as prospects that may improve cutaneous wound repair in general and in irradiated skin.

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“…BERNSTEIN et al 4 , em 1994, apresentaram estudo mostrando que seqüelas da radiação ionizante são decorrentes da pobre reparação da ferida.…”

Section: Introductionunclassified

Efeito de baixas doses de radiação X em feridas suturadas e não suturadas - estudo experimental em ratos

Bóscolo

Almeida

Vizioli

et al. 2000

Pesqui. Odontol. Bras.

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O presente trabalho avaliou o efeito de baixas doses de radiação X no processo de reparação tecidual em feridas suturadas e não suturadas em ratos. Para tanto, foi produzida nos animais uma ferida medindo 20 x 5 mm, sendo suturada ou não, dividindo-se os animais em 4 grupos: controle sem sutura, irradiado sem sutura, controle com sutura e irradiado com sutura. Os animais irradiados foram, no momento da irradiação, protegidos com um avental de chumbo de 2 mm de espessura com uma abertura, a qual permitia que fosse exposta somente a ferida cirúrgica. Cada animal sofreu 18 segundos de irradiação, totalizando 7,4 rad. O processo de reparação tecidual foi avaliado pela coloração por hematoxilina-eosina, verificando-se a morfologia do tecido de granulação e a impregnação argêntica para observação da síntese de colágeno, através da microscopia de polarização. Os resultados mostraram que a radiação, apesar de ter causado atraso, não impediu a reparação tecidual, sendo que o grupo que sofreu irradiação e não foi suturado mostrou maior retardo, quando comparado aos outros grupos.UNITERMOS: Suturas; Radiação ionizante; Cicatrização de feridas. INTRODUÇÃODescoberta há cerca de 100 anos, a radiação X continua a trazer grandes benefícios aos seus usuários. Entretanto, sabe-se da ação lesiva da radiação X sobre o tecido vivo, sendo conhecido também que baixas doses de radiação levam a um retardo no processo de reparação tecidual 1,2,14,18,19 . O retardo produzido pela radiação na cicatrização de feridas, segundo BRYANT et al. 5 (1968)

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Healing Impairment of Open Wounds by Skin Irradiation

Abstract: Radiation of skin results in slower healing of open wounds, and provides an in vivo system for evaluation of topical dressings and growth factors in radiation-impaired wounds.

Cited by 33 publications

References 21 publications

Effect of low-intensity laser irradiation (660 nm) on a radiation-impaired wound-healing model in murine skin

Effect of low-intensity laser irradiation (660 nm) on a radiation-impaired wound-healing model in murine skin

Radiotherapy and wound healing: Principles, management and prospects (Review)

Efeito de baixas doses de radiação X em feridas suturadas e não suturadas - estudo experimental em ratos

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