Healing of dermal wounds property of Caryocar brasiliense oil loaded polymeric lipid-core nanocapsules: formulation and in vivo evaluation

Pires, Jader; Cargnin, Simone Tasca; Costa, Suéllen Alves; Sinhorin, Valéria Dornelles Gindri; Damazo, Amílcar Sabino; Sinhorin, Adilson P.; Bicudo, Rogério de Campos; Cavalheiro, Larissa; Valladão, Dênia Mendes de Souza; Pohlmann, Adriana Raffin; Guterres, Sílvia Stanisçuaski; Ferrarini, Stela Regina

doi:10.1016/j.ejps.2020.105356

Cited by 21 publications

(15 citation statements)

References 59 publications

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“…This equipment contains mobile and fixed knives that finely cut the sample. Decreasing the size to facilitate the organic extraction process, the oil was extracted with an organic solvent, hexane, at a ratio of 1:5 (m/v) in ultrasound for 2 h at a mean temperature of 40 • C. Subsequently, the extract was filtered to separate the solid waste and was then subjected to rotary evaporation at the same temperature to completely remove the solvent from the sample [8]. Pequi oil was characterized in triplicate according to the Brazilian Pharmacopeia V and by 1RMN (Bruker Avance spectrometer 400 MHz, Billerica, USA), and the unsaturated fatty acid composition, as oleic acid, was measured by gas chromatography by Agilent Technologies, GC: 7890A and MS: 5975C, Saint Clara, USA).…”

Section: Pequi Oil (Caryocar Brasiliense Cambess) Extraction and Charmentioning

confidence: 99%

Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice

et al. 2020

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Pequi is a Brazilian fruit used in folk medicine for pulmonary diseases treatment, but its oil presents bioavailability limitations. The use of nanocarriers can overcome this limitation. We developed nanoemulsions containing pequi oil (pequi-NE) and evaluated their effects in a lipopolysaccharide (LPS)-induced lung injury model. Free pequi oil or pequi-NE (20 mg/kg) was orally administered to A/J mice 16 and 4 h prior to intranasal LPS exposure, and the analyses were performed 24 h after LPS provocation. The physicochemical results revealed that pequi-NE comprised particles with mean diameter of 174–223 nm, low polydispersity index (0.11 ± 0.01), zeta potential of −7.13 ± 0.08 mV, and pH of 5.83 ± 0.12. In vivo evaluation showed that free pequi oil pretreatment reduced the influx of inflammatory cells into bronchoalveolar fluid (BALF), while pequi-NE completely abolished leukocyte accumulation. Moreover, pequi-NE, but not free pequi oil, reduced myeloperoxidase (MPO), TNF-α, IL-1β, IL-6, MCP-1, and KC levels. Similar anti-inflammatory effects were observed when LPS-exposed animals were pre-treated with the nanoemulsion containing pequi or oleic acid. These results suggest that the use of nanoemulsions as carriers enhances the anti-inflammatory properties of oleic acid-containing pequi oil. Moreover, pequi’s beneficial effect is likely due its high levels of oleic acid.

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Section: Pequi Oil (Caryocar Brasiliense Cambess) Extraction and Charmentioning

confidence: 99%

Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice

et al. 2020

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“…Another study investigated the role of LNC containing Caryocar brasiliense Cambess in wound healing. The results indicated that this formulation is the best alternative for release systems, avoiding losses and complications related to cutaneous lesions in wound [ 68 ].…”

Section: Mechanism Of Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Far

Naimi-Jamal

Sedaghat

et al. 2023

JFB

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Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

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“…Phytosynthesized nanoparticles (nanoparticles obtained using natural extracts, for which the phytocomponents acts as both reducing and capping agents) proved to be more effective as antibacterial agents, being an alternative to the chemical compounds, providing long term durability against the microbial growth in an exterior of traditional cotton fabrics, by harnessing the antimicrobial properties of the nanoparticles and of the phytocomponents involved [77]. Moreover, plants extracts can be loaded into various polymers, enhancing hemostasis and speeding up tissue regeneration [78,79], or coated on the polymer support, thus being a simple, reproducible and cost-effective approach [80]. For wound healing dressings in the form of hydrogels, natural extracts can modify the morphology of the bio-composite by suppressing the crystallinity behavior [81] an important aspect being represented by the condition for the pores of the support material to have proper dimensions, to achieve the release of the encapsulated drugs and molecules, as well as to prevent the bacterial invasion [82].…”

Section: Coating Materials For Biomedical Applicationsmentioning

confidence: 99%

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Fierăscu

Chican

2021

Coatings

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In recent decades, coating materials have gained researchers’ interest, finding applications in different areas such as antimicrobial coatings for biomedical applications, coatings for increasing the shelf-life of commercial products, or coatings for the conservation of cultural heritage artifacts. The use of new types of coating materials based on natural ingredients can lead to the removal of harmful chemicals and contribute to the development of materials having different and promising properties. New challenges can appear both in the production process, as well as in the case of final application, when coating materials must be applied on various supports. The present review paper aims to be a critical discussion regarding the possibility of using natural ingredients as functional coatings, and to prove that the same material can be used in different fields, from the biomedical to environmental, or from cultural heritage protection to the food and cosmetic industries. The paper is based on the newest published studies, and its main goal is to be an inspiration source for researchers, in order to create more functional and applicable composite coatings in specific fields.

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Healing of dermal wounds property of Caryocar brasiliense oil loaded polymeric lipid-core nanocapsules: formulation and in vivo evaluation

Cited by 21 publications

References 59 publications

Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice

Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

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