Healing of periodontal defects treated with enamel matrix proteins and root surface conditioning—an experimental study in dogs

The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review

“…Treatment with GTR, EMD or EMD + GTR resulted in the formation of cementum with inserting collagen fibers as well as of alveolar bone [58,59] . Comparable results were also reported in rat, dog and monkey defects, with either spontaneous intrabony and experimentally created intrabony, recession or dehiscence-type defects [60][61][62][63][64] . A histomorphometrical study in dogs evaluated the effectiveness of EMD to induce regeneration of periodontal tissues in class II furcation lesions with or without GTR [65] .…”

Bone grafting material in combination with Osteogain for bone repair: a rat histomorphometric study

“…The key components improving new bone formation in the present study were the effects of enamel matrix proteins which have been shown to affect new bone formation under various models and also utilizing various carrier systems [20,[31][32][33][34][35]. In a classical study by Boyan et al, it was shown that although EMD does not possess osteoinductive potential, it possessed osteopromotive benefits when it is combined with active demineralized freeze-dried bone allografts (DFDBA) and resulted in enhanced bone induction [31].…”

Enamel matrix protein derivatives: role in periodontal regeneration

“…Treatment with GTR, EMD, or EMD + GTR resulted in the formation of cementum with insertion of collagen fibers as well as formation of alveolar bone 66,67. Comparable results were also reported in rat, dog, and monkey defects, with either spontaneous intrabony and experimentally created intrabony, recession, or dehiscence-type defects 68–72…”