Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice

Abu-Al-Basal, Mariam A.

doi:10.1016/j.jep.2010.07.007

Cited by 134 publications

(62 citation statements)

References 38 publications

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“…Topical application of essential oil of R. officinalis was used on wounds of diabetic mice for 3 days. Decreased inflammation, increased wound contraction, re-epithelialization, regeneration of granulation tissue and angiogenesis, as well as collagen deposition, were detected in the treated wounds [40]. …”

Section: Resultsmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

207

137

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Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms.

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Section: Resultsmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

207

137

View full text Add to dashboard Cite

show abstract

“…Fr. (Sparassidaceae), Momordica charantia (Cucurbitaceae), Rosmarinus officinalis L. (Rosemary), Withania coagulans Dunal. (Solanaceae), Annona squamosa L. (Annonaceae) and Martynia annua L. (Martyniaccae) .…”

Section: Introductionunclassified

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Parmar

Shende

Katare

et al. 2018

Journal of Pharmacy and Pharmacology

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“…In recent decades, traditional medicine has become more popular. A main reason of this popularity is that herbs are rich in natural antioxidants . Natural antioxidants have an important role in the prevention of many diseases.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Rizk

Masoud

Maher

2017

J Biochem & Molecular Tox

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Doxorubicin (DOX) is a chemotherapeutic agent widely used in human malignancies. Its long-term use cause neurobiological side effects. The aim of the present study was to investigate the prophylactic effect exerted by daily administration of ellagic acid (EA) and rosmarinic acid (RA) on DOX-induced neurotoxicity in rats. Our data showed that DOX-induced significant elevation of brain malondialdehyde, tumor necrosis factor-alpha (TNF-α), inducible nitric oxide synthase (iNOS), caspase-3, and cholinesterase associated with significant reduction in reduced glutathione, monoamines namely serotonin, dopamine, as well as norepinephrine. Concomitant administration of EA (10 mg/kg/day, p.o. for 14 days) and/or RA (75 mg/kg/day, p.o. for 14 days) with DOX significantly mitigated the neural changes induced by DOX. Meanwhile, treatment ameliorated pro-inflammatory cytokines as TNF-α, iNOS, and attenuated oxidative stress biomarkers as well as brain monoamines. In conclusion, EA and RA can effectively protect against DOX-induced neurotoxicity, and the mechanisms underlying the neuroprotective effect are potentially associated with its antioxidant, anti-inflammatory, and antiapoptotic properties.

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Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice

Cited by 134 publications

References 38 publications

Skin Wound Healing and Phytomedicine: A Review

Skin Wound Healing and Phytomedicine: A Review

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

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