Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

Abstract

The high prevalence of acquiring skin wounds, along with the emergence of antibiotic-resistant strains that lead to infections, impose a threat to the physical, mental, and socioeconomic health of society. Among the wide array of wound dressings developed, hydrogels are regarded as a biomimetic soft matter of choice owing to their ability to provide a moist environment ideal for healing. Herein, neutral glycol chitosan (GC) was cross-linked via imine bonds with varying concentrations of dibenzaldehyde-terminated polyethylene glycol (DP) to give glycol chitosan/dibenzaldehyde-terminated polyethylene glycol hydrogels (GC/DP). These dynamic Schiff base linkages (absorption peak at 1638 cm–1) within the hydrogel structure endowed their ability to recover from damage as characterized by high-low strain exposure in continuous step strain rheology. Along with their good injectability and biodegradability, the hydrogels exhibited remarkable inhibition against E. coli, P. aeruginosa, and S. aureus. GC/DP hydrogels demonstrated high LC50 values in vivo using zebrafish embryos as a model system due to their relative biocompatibility and a remarkable 93.4 ± 0.88% wound contraction at 30-dpw against 49.1 ± 3.40% of the control. To the best of our knowledge, this is the first study that developed injectable glycol chitosan/dibenzaldehyde-terminated polyethylene glycol self-healing hydrogels for application in wound healing with intrinsic bacteriostatic properties against the three bacteria.

A Bifunctional Wearable Sensor Based on a Nanoporous Membrane for Simultaneous Detection of Sweat Lactate and Temperature

“…The electrochemical responses of the LO x @CS PC sensor display better stability over 13 days with a relative standard deviation (RSD) of 4.24% (the response currents after 13 days are shown in Figure S5). The reason could be attributed to the perfect encapsulation matrix of CS hydrogels, which not only inhibits bacteria but also locks water effectively, providing a stable living environment for the enzymes . However, due to water loss of CS hydrogels in low temperature, the activity of LO x drastically reduces to 35% of initial activity .…”

Ecofriendly Controlled-Release Insecticide Carrier: pH-/Temperature-Responsive Rosin-Derived Hydrogels for Avermectin Delivery against Mythimna separata (Walker)

“…At last, in view of the potential toxicity of the slow-release hydrogel to nontarget organisms, we believe that the environmental compatibility of AVM@DA-PNIPAM-Zn 2+ can be improved, reducing their toxicity by modifying rosin, PNIPAM, and other materials. , Second, adding small amounts of biocompatible additives (such as polyethylene glycol (PEG) and biochar) can decrease the high toxicity of controlled release materials to aquatic organisms. , Furthermore, optimizing the dosage of the drug AVM and avoiding excessive use, and adjusting the release rate of the controlled release material. Additionally, our subsequent study will investigate deeper into the biological toxicity of the AVM@DA-PNIPAM-Zn 2+ under various pH and temperature conditions, aiming to further unearth its latent application potential.…”

Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

“…174 This is consistent with the similar acquired antibacterial property of PEG-based hydrogel reported by Balitaan et al , which was found to inhibit S. aureus , P. aeruginosa and E. coli without any antibiotics. 175 Moreover, Ha et al developed an in situ -gelation injectable hydrogel consisting of methoxy polyethylene glycol- b -polycaprolactone (MPEG-PCL) and collagen-mimetic peptide GFOGER-conjugated PEG-PCL (GFOGER-PEG-PCL). 176 Owing to the added GFOGER, it significantly increased the expression of integrins and FAK, and induced downstream signaling of p38 and ERK, which finally exhibited remarkable promotion of osteochondral regeneration.…”