Health and economic burden of pathological lesions in livers and lungs of slaughtered sheep at Mosul Abattoir, Iraq

Jwher, Dhyaa M.; Dahl, Mohammad O.; Saeed, None Shahad I.; Abdalazeez, None Aomnea M.

doi:10.1002/vms3.803

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…In animals, it is asymptomatic, and its diagnosis is performed at necropsy while post-mortem inspection 8 . In this disease, different pathological lesions and abnormal organ tissues are found in slaughtered animals which were apparently healthy 9 , 10 . The control of hydatidosis requires a good understanding of all aspects related to the parasite survival, particularly protoscolex 11 and it is achieved by long term prevention strategies targeting meat inspection, dogs’ deworming, health education, and surveillance in livestock and human individuals 12 .…”

Section: Introductionmentioning

confidence: 99%

In vitro and ex vivo protoscolicidal effect of poly(amidoamine) nanoemulsion against Echinococcus granulosus

Aboelsoued,

Toaleb,

Ibrahim

et al. 2024

Sci Rep

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Hydatidosis causes a serious health hazard to humans and animals leading to significant economic and veterinary and public health concern worldwide. The present study aimed to evaluate the in vitro and ex vivo protoscolicidal effects of synthesized poly(amidoamine), PAMAM, nanoemulsion. In this study, PAMAM was characterized through dynamic light scattering technique to investigate the particle size and zeta potential of nanoemulsified polymer. For the in vitro and ex vivo assays, we used eosin dye exclusion test and scanning electron microscope (SEM) to evaluate the effects of the prepared and characterized PAMAM nanoemulsion against protoscoleces from Echinococcus granulosus sensu lato G6 (GenBank: OQ443068.1) isolated from livers of naturally infected camels. Various concentrations (0.5, 1, 1.5 and 2 mg/mL) of PAMAM nanoemulsion at different exposure times (5, 10, 20 and 30 min) were tested against protoscolices. Our findings showed that PAMAM nanoemulsion had considerable concentration- and time-dependent protoscolicidal effect at both in vitro and ex vivo experiments. Regarding in vitro assay, PAMAM nanoemulsion had a potent protoscolicidal effect when compared with the control group with a highest protoscolicidal activity observed at the concentration of 2 mg/mL at all exposure times, such that 100% of protoscolices were killed after 20 min of exposure. Also, the mortality of protoscolices was 100% after 30 min of exposure to 1 and 1.5 mg/mL of PAMAM nanoemulsion, in vitro. Concerning ex vivo assay PAMAM nanoemulsion recorded the highest mortality rates at the concentration of 2 mg/mL (55, 99.4 and 100% at 10, 20, 30 min, respectively). Ultrastructure examination of examined protoscolices after 20 min of exposure to PAMAM nanoemulsion showed a complete loss of rostellar hooks, disruption of suckers with disorganization of hooks with partial or complete loss of them, and damage of protoscolices tegument with loss of their integrity in the form of holes and contraction of the soma region were observed in 1.5 and 2 mg/mL of PAMAM, in vitro and ex vivo, showing more damage in the in vitro conditions. It can be concluded that PAMAM nanoemulsion is a promising protoscolicidal agent offering a high protoscolicidal effect at a short exposure time. Further in vivo studies and preclinical animal trials are required to evaluate its efficacy and clinical applications against hydatid cysts.

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Section: Introductionmentioning

confidence: 99%

In vitro and ex vivo protoscolicidal effect of poly(amidoamine) nanoemulsion against Echinococcus granulosus

Aboelsoued,

Toaleb,

Ibrahim

et al. 2024

Sci Rep

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Health and economic burden of pathological lesions in livers and lungs of slaughtered sheep at Mosul Abattoir, Iraq

Jwher

Dahl

Saeed

et al. 2022

Veterinary Medicine & Sci

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Background Slaughterhouses can provide valuable information about animal diseases and their epidemiology. Objectives The current study was designed to examine the health and economic burden of pathological lesions in livers and lungs of slaughtered sheep at Mosul abattoir, Iraq. Methods Mosul abattoir records for sheep slaughtered between 2011 and 2013 were considered for inclusion in this study. The direct financial loss due to liver and lung lesions was estimated considering the average number of slaughtered sheep per year, the average percentage of liver lesions per year, and the average percentage of lung lesions per year. Monetary values of the liver and lung were obtained from local butcheries. Results The analysis indicated that the percentage of lesions observed in the liver and lung per year was 6.9% and 5.8%, respectively. Hydatid cyst followed by hepatitis was the most frequent lesions identified in the liver, while pneumonia then hydatid cyst were detected in the lung, followed by worms, abscess, and miscellaneous lesions. Hydatid cyst was the most frequently observed lesions. The average total loss was 35,232 USD per year (mostly due to liver lesions), with ±7046 USD sensitivity to the price change. Conclusions The percentage of lesions observed in the liver and lung per year is not negligible and can cause considerable economic losses.

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Health and economic burden of pathological lesions in livers and lungs of slaughtered sheep at Mosul Abattoir, Iraq

Cited by 2 publications

References 12 publications

In vitro and ex vivo protoscolicidal effect of poly(amidoamine) nanoemulsion against Echinococcus granulosus

In vitro and ex vivo protoscolicidal effect of poly(amidoamine) nanoemulsion against Echinococcus granulosus

Health and economic burden of pathological lesions in livers and lungs of slaughtered sheep at Mosul Abattoir, Iraq

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