Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene

Wang, W; Cheng, Lijun; Yi, Jun; Gan, Jia; Tang, Hui; Fu, Min; Wang, H; Lai, Songjia

doi:10.4238/2015.april.17.6

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…Bovine milk fat percentage is known to be influenced by genetic variation in many genes located on different chromosomes, e.g., chromosomes 1, 3, 4, 5, 6, 7, 8, and 18 (Boichard et al, 2003;Viitala et al, 2003;Ashwell et al, 2004;Schnabel et al, 2005;Hayes et al, 2010;Wang et al, 2013b;Wang et al, 2015). Milk fat percentage is a polygenic trait, controlled by many genes.…”

Section: Discussionmentioning

confidence: 99%

Association of CD4 SNPs with fat percentage of Holstein cattle

Usman

Zhai

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Cluster of differentiation 4 gene (CD4) is well known for its role in immunity, but its effects on production traits remain to be elucidated. The present study was designed to explore single nucleotide polymorphisms (SNPs) in the exons, flanking introns, and promoter of CD4, as well as to analyze their effects on milk production traits (percentage of protein, fat, and lactose; mastitis indicator traits somatic cell count; and somatic cell score). A total of 10 SNPs, including eight in the exon and two in the intron regions, were identified using pooled DNA sequencing. These SNPs were screened in a population of 258 Chinese Holstein using the SNaPshot technique. We analyzed the effects of SNPs, parity, herd, year, and season of calving on the production and mastitis indicator traits. Our analysis revealed two haplotypes and strong linkage disequilibrium (D' > 0.97) among all SNPs. All 10 SNPs were significantly associated with fat percentage (P < 0.01). Cows homozygous for the wild-type genotypes had higher fat percentages than those with the other genotypes. The dominant and additive effects were also significant for fat percentage (P < 0.05). These results suggest that CD4 plays a role in production traits as well as in immune function. The identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage. We propose further studies of these SNPs in a larger population as well as further investigations of the function of this gene.

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Section: Discussionmentioning

confidence: 99%

Association of CD4 SNPs with fat percentage of Holstein cattle

Usman

Zhai

et al. 2016

Genet. Mol. Res.

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“…However, previous studies have also reported candidate genes that are significantly associated with diverse traits such as milk production traits and disease resistance (Wang et al, 2015). The results described herein indicate that five SNPs located in the DGAT1 gene are significantly associated (P < 0.05), or show a statistical trend for association (P < 0.1), with milk yield, milk fat, and milk protein.…”

Section: Discussionmentioning

confidence: 51%

Molecular markers located on the DGAT1, CAST, and LEPR genes and their associations with milk production and fertility traits in Holstein cattle

Hill¹,

Canal²,

Bondioli³

et al. 2016

Genet. Mol. Res.

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“…The hap21 (TA) was significantly associated with elevated SCS EBVs (p = 0.0120) [49]. Wang et al [50] showed that transitions (A→T) at position 114 bp were associated with the somatic cell score (p ≤ 0.01). The G→A at position 1594 bp plays a critical role in increasing 305-day milk yields in Chinese Holstein and Chinese Simmental breeds.…”

Section: Candidate Genes With Predicted Functionsmentioning

confidence: 97%

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

2023

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Lipids consumed with milk derivatives are one of the main parts of the human diet. Trans fatty acids in milk are causing a debate about their impact on the incidence of cardiovascular disease, pathological abnormalities, and cancer. The fatty acid profile of milk is influenced by a large number of different factors, one of which is genetic. The development of genetic studies, including Genome-Wide Association Studies (GWAS), may help define genomic regions associated with fatty acid content in milk, including trans fatty acids. This article provides an overview of international studies on the identification of genomic regions and SNPs associated with the trans fatty acids in cow’s milk. The results are based on research of cattle such as Norwegian Red cattle, Holstein, Jersey, and Brown Swiss. The presented review shows that 68 SNPs were localized on chromosomes 1, 2, 4–6, 8–10, 12, 14–20, 22–25, and 27–29. Further research in this direction will provide new information that will serve as an impetus for the creation of modern breeding technologies and increase the performance of the manufacture of high-quality dairy products. The search for genetic markers associated with the content of TFA in milk is a promising direction in agricultural science and will allow more complete breeding work with cattle.

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Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene

Cited by 6 publications

References 17 publications

Association of CD4 SNPs with fat percentage of Holstein cattle

Association of CD4 SNPs with fat percentage of Holstein cattle

Molecular markers located on the DGAT1, CAST, and LEPR genes and their associations with milk production and fertility traits in Holstein cattle

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

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