Health and Racial Disparity in Breast Cancer

Yedjou, Clément G.; Sims, Jennifer N.; Miele, Lucio; Noubissi, Felicite K.; Lowe, Leroy; Fonseca, Duber D.; Alò, Richard A.; Payton, Marinelle; Tchounwou, Paul B.

doi:10.1007/978-3-030-20301-6_3

Cited by 354 publications

(258 citation statements)

References 124 publications

(136 reference statements)

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“…In particular, in the United States and in the United Kingdom, race and ethnicity have appeared to be important correlates of rates of infection and of adverse outcomes in patients with COVID-19 in general (Chowkwanyun and Reed, 2020;Williamson et al, 2020;Yancy, 2020). This result mirrors the relationship previously observed between adverse outcomes in other diseases, including cancer, and race and ethnicity (Badal et al, 2020;Marinac et al, 2020;Marinaro et al, 2020;Yedjou et al, 2019). These health disparities are thought to be largely driven by socioeconomic status, lack of sufficient access to care, and area of residence, but biological factors have been implicated in certain instances (although not with COVID-19).…”

Section: Regionsupporting

confidence: 56%

COVID-19 and Cancer: Current Challenges and Perspectives

et al. 2020

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Patients with cancer have been disproportionately affected by the COVID-19 pandemic. This effect has included the adverse outcomes in patients with cancer who develop COVID-19, the impact of the COVID-19 pandemic on the delivery of cancer care, and the severe disruption to cancer research. However, patients with cancer are a heterogeneous population, and recent studies have now documented factors that allow risk stratification of patients with cancer in order to optimize care. In this review, we highlight data at the intersection of COVID-19 and cancer, including the biological interplay between the two diseases and practical recommendations for the treatment of patients with cancer during the pandemic. We additionally discuss the potential long-lasting impact of the pandemic on cancer care due to its deleterious effect on cancer research, as well as biological insights from the cancer research community that could help develop novel therapies for all patients with COVID-19.

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Section: Regionsupporting

confidence: 56%

COVID-19 and Cancer: Current Challenges and Perspectives

et al. 2020

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“…This could be explained by the fact that socioeconomic psychological factors and genetic diversity might play an important role in tumorigenesis and tumor progression (20)(21)(22). Several previous studies did demonstrate that marital status and ethnicities were important etiological and prognostic factors in several solid tumors, including cervical cancer (23)(24)(25)(26). Similarly, in our study better survival was seen in married patients and in white women.…”

Section: Discussionsupporting

confidence: 74%

Small Cell Carcinoma as an Independent Prognostic Factor for Cervical Cancer Patients: A Population-Based Analysis

Wang

Song

et al. 2020

Preprint

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Background: Small cell carcinoma (SmCC) of cervix was a rare neoplasm with little recognition. Population-based study describing difference in characteristics and outcomes between SmCC and squamous cell carcinoma (SCC), usual type, was limited. Here, we used the Surveillance, Epidemiology, and End Results (SEER) database to compare SmCC with SCC and investigated the prognostic values of the clinicopathological characteristics and survival outcomes in SmCC of cervix.Methods: Patients diagnosed with cervical SmCC and SCC in SEER database from 2004-2015 were enrolled in analysis. Propensity-score matching analysis (PSM) was used to balance baseline characteristics between patients who were cervical SmCC and those who were cervical SCC. Cox regression models and Kaplan-Meier methods were conducted to analyze survival data before and after PSM. Stratified analyses were performed to investigate the risk of mortality at different stage. Results: In total, 25345 patients including 287 cervical SmCC patients and 25058 cervical SCC patients were enrolled our analysis. Both histological subtypes were more common in unmarried women and in white populations. Compared with cervical SCC patients, cervical SmCC patients showed a higher rate of larger tumor size (tumor size ≥4 cm, 33.8% vs 51.9%, P<0.001), higher grade disease (grade III-IV, 32.2% vs 58.9%, P<0.001), regional lymph node involvement (22.5% vs 49.5%, P<0.001) and distant metastasis (10.3% vs 32.4%, P<0.001). Before PSM, multivariate regression model revealed that SmCC histology (P<0.001) and advanced FIGO stages (P<0.001) were principal prognostic factors of poor survival for cervical patients. After PSM, 1060 patients in SCC group were 4:1 matched with 278 patients in SmCC group. Multivariate regression model in PSM cohort showed histology and FIGO stage were crucial prognostic factors for survival. Kaplan-Meier survival curves clearly showed that cervical SmCC patients had worse survival than that of patients with SCC in all stages, stage I-II, III, IV before and after PSM analysis.Conclusion: Compared to patients with cervical SCC, those with cervical SmCC showed a worse survival before and after adjustment baseline characteristic in all stages. SmCC was an independent poor prognostic factor in cervical cancer patients.

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“… 2 Female BRCA carriers have a 60–70% lifetime risk of developing breast cancer compared to 12% in the general population, 2 and up to a 50% or greater risk of developing a second primary breast cancer. 3 – 7 Evidence-based interventions such as risk-reducing surgery and breast cancer screening exist for cancer prevention and early diagnosis among BRCA carriers. 8 – 10 Moreover, in addition to the personal impact of identifying HBC, this information may be shared with at-risk family members to amplify the benefits of testing and subsequent care among those at high risk.…”

Section: Introductionmentioning

confidence: 99%

Disparities in BRCA counseling across providers in a diverse population of young breast cancer survivors

Reid

Cragun

Tezak

et al. 2020

Genetics in Medicine

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Purpose: All women diagnosed with breast cancer (BC) ≤ age 50 should be referred for genetic counseling (GC) and testing. We sought to compare differences in provider practices and access across a racially and ethnically diverse population of young BC survivors. Methods: A registry-based sample of women diagnosed with invasive BC ≤ age 50 from 2009 to 2012 was recruited through the Florida Cancer Registry, and completed a questionnaire and medical record release. Differences were compared across those tested with or without the involvement of a board-certified or credentialed genetics health professional (GHP) in 1) clinical and demographic variables; and 2) pre-test GC elements. Results: Of 1622 participants, there were 440 Blacks, 285 Hispanics, and 897 Non-Hispanic Whites. Of 831 participants with medical record verification of testing provider, 170 (20%) had documentation of GHP involvement. Among the 613 who recalled a pre-test discussion and had GC elements collected, those with GHP involvement were significantly more likely to recall the seven recognized GC elements. Conclusion: GHP involvement was associated with adherence to nationally recommended best practices. With the expanding importance of identifying inherited cancers, it is critical to ensure equitable access to best practices across all populations.

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Health and Racial Disparity in Breast Cancer

Cited by 354 publications

References 124 publications

COVID-19 and Cancer: Current Challenges and Perspectives

COVID-19 and Cancer: Current Challenges and Perspectives

Small Cell Carcinoma as an Independent Prognostic Factor for Cervical Cancer Patients: A Population-Based Analysis

Disparities in BRCA counseling across providers in a diverse population of young breast cancer survivors

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