Health Assessment of Employees With Different Body Burdens of Lead

Ramirez-Cervantes, B; Embree, J.W.; Hine, Charles H.; Nelson, Kali; Varner, Michael O.; Putnam, Robert D.

doi:10.1097/00043764-197809000-00009

Cited by 17 publications

(8 citation statements)

References 7 publications

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“…Cramer and Dahlberg [ 19661 tested 364 workers in a battery factory and classified them into two groups, a lead affected group and a lead unaffected group, and found no statistically significant differences between them in terms of arterial pressure. Ramirez-Cervantes et al [1978] studied 652 lead foundry workers with at least 5 years of exposure and found no differences in systolic and diastolic blood pressure. In another study, Parkinson et al [1987] examined the relationship between occupational exposure to lead and diastolic and systolic blood pressure in 270 exposed and 158 nonexposed individuals.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to lead, kidney function tests, and blood pressure

Santos

Colacciopo

Bó

et al. 1994

American J Industrial Med

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In the present study we examined sensitive biochemical markers of kidney function and damage in 166 workers exposed to lead and in 60 control workers. The objective was to investigate the chronic renal toxicity of lead and its possible correlation with arterial pressure. Diastolic arterial pressure was higher in the exposed group (p < 0.05), but the two groups did not differ in systolic pressure. Median activity of urinary N-acetyl-beta-D-glucosaminidase was higher in the exposed group (p < 0.001), and correlated with blood lead levels (p < 0.001) and duration of exposure (p < 0.001), but not with arterial pressure. The other indicators studied, gamma-glutamyl-transpeptidase and alanine-aminopeptidase activity, urine albumin, and total urine protein, were not higher than in the control group and were not correlated with blood lead, duration of exposure, or arterial pressure.

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to lead, kidney function tests, and blood pressure

Santos

Colacciopo

Bó

et al. 1994

American J Industrial Med

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“…Several studies noted associations between lead exposure (assessed by blood lead, years of exposure, and/or zinc protoporpyhrin (ZPP)) and clinical renal outcomes (blood urea nitrogen (BUN), serum creatinine, and/or creatinine clearance) and/or early biological effect (EBE) markers, such as N-acetyl-β-D-glucosaminidase (NAG) and retinol-binding protein (RBP). [10][11][12][13][14][15][16] These studies had smaller sample sizes than the environmental studies (median sample size = 218) and statistical analysis was more limited, consisting of correlations or simple linear regression in half with the other half controlling for age and, in one, 16 age, height, and weight. In contrast, other occupational studies have either found no significant difference in renal measures in lead workers compared to controls and/or few to no associations when continuous lead measures were analysed.…”

Section: Main Messagesmentioning

confidence: 99%

Associations of lead biomarkers with renal function in Korean lead workers

Kd³

et al. 2003

Occup Environ Med

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Aims: To compare associations of lead biomarkers with renal function in current and former lead workers. Methods: Cross sectional analysis of first year results from a longitudinal study of 803 lead workers and 135 controls in South Korea. Clinical renal function was assessed by blood urea nitrogen (BUN), serum creatinine, and measured and calculated creatinine clearance. Urinary N-acetyl-β-Dglucosaminidase (NAG) and retinol-binding protein were also measured. Results: Mean (SD) tibia lead, blood lead, and DMSA chelatable lead levels in lead workers were 37.2 (40.4) µg/g bone mineral, 32.0 (15.0) µg/dl, and 767.8 (862.1) µg/g creatinine, respectively. Higher lead measures were associated with worse renal function in 16/42 models. When influential outliers were removed, higher lead measures remained associated with worse renal function in nine models. An additional five associations were in the opposite direction. Effect modification by age was observed. In 3/16 models, associations between higher lead measures and worse clinical renal function in participants in the oldest age tertile were significantly different from associations in those in the youngest age tertile which were in the opposite direction. Mean urinary cadmium (CdU) was 1.1 µg/g creatinine (n = 191). Higher CdU levels were associated with higher NAG. Conclusions: These data suggest that lead has an adverse effect on renal function in the moderate dose range, particularly in older workers. Associations between higher lead measures and lower BUN and serum creatinine and higher creatinine clearances may represent lead induced hyperfiltration. Environmental cadmium may also have an adverse renal impact, at least on NAG.

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“…Two studies reported only on young children (Ͻ10 years), 25,37 two studies were case reports, 45,48 one 66 recruited less than 50 persons, in one 54 owing to missing information the analysis was performed in less than 50 subjects, five estimated exposure from other measurements than the blood lead concentration, 30,77,78,81,88 and 11 did not provide enough information to compute the association size. 17,19,22,26,27,36,39,62,63,67,86 …”

Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58 518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and

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Health Assessment of Employees With Different Body Burdens of Lead

Cited by 17 publications

References 7 publications

Occupational exposure to lead, kidney function tests, and blood pressure

Occupational exposure to lead, kidney function tests, and blood pressure

Associations of lead biomarkers with renal function in Korean lead workers

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

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