Occupational exposure to lead, kidney function tests, and blood pressure

Santos, Antônio Cardozo dos; Colacciopo, Sergio; Bó, Creuza M. R. Dal; Santos, Neife Aparecida Guinaim dos

doi:10.1002/ajim.4700260506

Cited by 54 publications

(29 citation statements)

References 31 publications

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“…Hertz Picciotto [24] suggested a small positive association between blood lead and blood pressure in both occupational and general population. Dos Santos and Maheswaran [25,26] noted a significant correlation between systolic and diastolic blood pressure and duration of exposure to lead. These studies suggest that the blood pressure is correlated with Pb-B and Pb-U.…”

Section: Discussionmentioning

confidence: 98%

Biochemical Effects of Lead Exposure on Battery Manufacture Workers with Reference to Blood Pressure, Calcium Metabolism and Bone Mineral Density

et al. 2012

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Section: Discussionmentioning

confidence: 98%

Biochemical Effects of Lead Exposure on Battery Manufacture Workers with Reference to Blood Pressure, Calcium Metabolism and Bone Mineral Density

et al. 2012

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“…Two studies reported only on young children (Ͻ10 years), 25,37 two studies were case reports, 45,48 one 66 recruited less than 50 persons, in one 54 owing to missing information the analysis was performed in less than 50 subjects, five estimated exposure from other measurements than the blood lead concentration, 30,77,78,81,88 and 11 did not provide enough information to compute the association size. 17,19,22,26,27,36,39,62,63,67,86 …”

Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58 518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and

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“…They can be useful in early diagnose of acute renal damage as nephrotoxicity caused by immunosuppressive drugs, contrast substances, antibiotics and cadmium exposition (3)(4)(5)(6)(7)(8)(9)(10). Urinary enzyme activity normally is very low in urine and is increased in renal tubular cell damage (11).…”

Section: Introductionmentioning

confidence: 99%

“…Sensitive methods for determination of enzyme activities in urine. 3. High concentration of examined enzymes in renal tissue.…”

Section: Introductionmentioning

confidence: 99%

Symmetric dimethyl arginine and N-acetyl- β-D-glucosaminidase lysosimyria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs.

Spasovski¹,

Latifi²,

Marina³

et al. 2013

J Nephropathol

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Background: The aim of this study was to determine the effect of initial therapy with some disease modifying antirheumatic drugs (DMARDs) (Methotrexate and Ketoprofen) on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA). Objectives: To determine whether there is a change in clinical and laboratory indicators of renal function in course of the follow up of treatment and whether that change correlates with the dynamics of the quantity of enzymes excreted in urine and reactants of the acute phase. Materials and Methods: Using colorimetric method for determination of NAG, samples of 70 participants were examined (35 RA patients treated with Ketoprofen only, 35 RA patients treated with combined use of Methotrexate and Ketoprofen). The follow up was 5 time-intervals in the course of 24 weeks. Results: There was moderate correlation between NAG and microalbuminuria (r=0,34) in the group of patients treated with Ketoprofen only, while statistically significant correlation (r=0,21) was seen in group of patients with combined use of Methotrexate and Ketoprofen. NAG enzymuria in size, number of patients registered, and time of appearance were greater and appears earlier in the group with the combined use of Methotrexate and Ketoprofen compared with the mono-therapy with Ketoprofen. Mean urinary NAG induction was increasing with the concomitant use of Methotrexate and Ketoprofen. Conclusions: Methotrexate is more potent NAG inductor than Ketoprofen and provokes greater tubular enzymuria than Ketoprofen. www.nephropathol.com DOI:10.5812/nephropathol.8989 J Nephropathology. 2013; 2(1): 36-52 Original Article Journal of NephropathologyImplication for health policy/practice/research/medical education: Determination of the urinary N-acetyl-β-D-glucosaminidase together with the urinary creatinine excretion could serve as a more sensitive test for renal lesions in patients suffering from rheumatoid arthritis, as an additional diagnostic tool, and the information for the status of the disease.

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Occupational exposure to lead, kidney function tests, and blood pressure

Cited by 54 publications

References 31 publications

Biochemical Effects of Lead Exposure on Battery Manufacture Workers with Reference to Blood Pressure, Calcium Metabolism and Bone Mineral Density

Biochemical Effects of Lead Exposure on Battery Manufacture Workers with Reference to Blood Pressure, Calcium Metabolism and Bone Mineral Density

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

Symmetric dimethyl arginine and N-acetyl- β-D-glucosaminidase lysosimyria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs.

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