Health-benefits of date fruits produced in Saudi Arabia based on in vitro antioxidant, anti-inflammatory and human tumor cell proliferation inhibitory assays

Zhang, Chuan‐Rui; Aldosari, Saleh A.; Vidyasagar, Polana S P V; Shukla, Paraj; Nair, Muraleedharan G.

doi:10.1016/j.jssas.2015.09.004

Cited by 47 publications

(42 citation statements)

References 10 publications

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“…Plasma sodium level was elevated in rats intoxicated with DOX compared with the normal control, and there was observed a decrease in elevated levels to normal values in groups received PDE as it was also reported previously that elevated levels of sodium was seen in rats having cardiac damage [34]. ere was a decrease in plasma potassium level in the group treated with DOX compared with the normal control group as cardiomyopathy caused hypokalaemia [35], and there was increase in potassium level near to normal Figure 4: Effects of PDE on urinary (a) sodium, (b) potassium, and (c) sodium-potassium ratio levels in DOX-induced changes in rats. e values are mean ± SEM (n � 6).…”

Section: Discussionsupporting

confidence: 76%

Phoenix dactyliferaProtects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

Wang

Chao

Ahmad

et al. 2019

Cardiology Research and Practice

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Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect of Phoenix dactylifera extract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity. Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days. Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA. Subsequently, DOX initiated changes in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE. PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity. Groups treated with different doses of PDE showed marked decrease in levels of cardiac and renal markers. The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity.

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Section: Discussionsupporting

confidence: 76%

Phoenix dactyliferaProtects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

Wang

Chao

Ahmad

et al. 2019

Cardiology Research and Practice

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“…Zhang et al (2013) determined the antioxidant activity of Ajwa dates through MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay along methanolic, acetate, and water extracts of date at 250 µg/ml that resulted in the inhibition of lipid peroxidation by 88%, 70%, and 91%, respectively Furthermore, Zhang, Aldosari, Vidyasagar, Shukla, and Nair (2017) evaluated the antioxidant potential of 29 different varieties of Saudi Arabian dates by water and methanolic extracts in MTT [3‐(4,5‐dimethylthiazole‐2‐yl)‐2,5‐diphenyltetrazolium bromide] antioxidant assay. The result revealed that the methanolic extract (250 µg/ml) possesses moderate activity with an absorbance value in a range of 0.14–0.41.…”

Section: Biological and Therapeutic Potential Of Datesmentioning

confidence: 99%

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

et al. 2020

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Date palm counts among the oldest fruit crops of the world and is mainly cultivated for its highly nutritious fruits consumed as a staple food in many countries, especially in the Gulf region. Dates are enriched with numerous therapeutic bioactives and functional compounds such as phenolics, flavonols, carotenoids, minerals, and vitamins that not only provide an appreciable amount of energy required for the human body but also act as an effective therapeutic agent against several diseases. This review aimed to provide a deep insight into the nutritional as well as phytochemicals profile of date fruit and its seeds in order to explore their biological (anti‐cancer, anti‐diabetic, cardio‐protective, anti‐inflammatory properties), functional food, and nutra‐pharmaceutical attributes. Practical applications This review provides updated information regarding the date fruits and seeds phytochemicals composition together with highlighting dates potential as a natural therapeutic agent against several diseases. The study also urges the importance of consuming dates as a great package to live a healthy life due to the functional food and nutraceutical properties of this valuable fruit. The study also provides information first time as recommending dates to cope with the hidden hunger or micronutrient deficiency faced by the third world inhabitants. Hence, the review may further help the industry and researchers to explore the potential of dates for future medicinal and nutra‐pharmaceutical applications.

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“…Production increased from 527881 tons in 1990, to 734844 tons in 2000, and to 1122820 tons in 2011 (FAOSTAT ; Abdel Gawad and others ). Zhang and others () mentioned that the date fruits production is more than 1 million metric tons per year accounting for about 14% of the total world production. However, Saudi date exports are relatively low.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Date Palm (Phoenix dactylifera L.) Seed Oil from Six Saudi Arabian Cultivars

Nehdi

Sbihi

Tan

et al. 2018

Journal of Food Science

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This study showed that date seed had great nutritional value due to which it can be used for food applications especially as frying or cooking oil. In addition, date oil has also potential to be used in cosmetic and pharmaceutical practices as well. The extraction of oil from Phoenix dactylifera seed on large scale can create positive socioeconomic benefits especially for rural communities and could also assist to resolve the environmental issues generated by excess date production in large scale date-producing countries such as Saudi Arabia.

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Health-benefits of date fruits produced in Saudi Arabia based on in vitro antioxidant, anti-inflammatory and human tumor cell proliferation inhibitory assays

Cited by 47 publications

References 10 publications

Phoenix dactyliferaProtects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

Phoenix dactyliferaProtects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

Chemical Composition of Date Palm (Phoenix dactylifera L.) Seed Oil from Six Saudi Arabian Cultivars

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