Health Benefits of<i>Prunus avium</i>Plant Parts: An Unexplored Source Rich in Phenolic Compounds

Jesus, Fábio Nascimento de; Gonçalves, Ana C.; Alves, Gilberto; Silva, Luís

doi:10.1080/87559129.2020.1854781

Cited by 21 publications

(22 citation statements)

References 190 publications

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“…The biological properties of P. avium stems, leaves, and flowers have been attributed to their phytochemical composition, mostly to their content in phenolic compounds. Several studies on extracts and aqueous infusions from cherry by-products have described many bioactivities such as antioxidant and anti-hyperglycemic activities [1,9,69]. This section will summarize the reports about the therapeutic potential of P. avium by-products in relation to antioxidant and anti-hyperglycemic activities.…”

Section: Biological Properties Of Prunus Avium L By-productsmentioning

confidence: 99%

Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review

et al. 2021

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Prunus avium L. (sweet cherry) is one of the most appreciated fruits due to its organoleptic and nutritional value. Interestingly, cherry leaves, stems, and flowers are agri-food by-products rich in bioactive compounds that are mostly still unexploited. Stems and leaves have been used in folk medicine since ancient times. Recently, cherry flowers have also proved to be an interesting source of compounds with therapeutic properties. Phenolic compounds, namely hydroxycinnamic acids and flavonoids, are the most present phytochemicals in P. avium fruits and their by-products. These compounds have shown a good antioxidant potential to prevent oxidative stress-related diseases and glycemic control, fundamental in preventing and controlling diabetes mellitus. The present review summarizes the main phenolics found in P. avium stems, leaves, and flowers as compared to their fruits and describes their antioxidant and anti-hyperglycemic properties. Thus, these by-products are an accessible and low-cost source of bioactive constituents with interesting health-promoting properties, making their use promising in diabetes therapy.

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Section: Biological Properties Of Prunus Avium L By-productsmentioning

confidence: 99%

Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review

et al. 2021

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“…On the other hand, flavonoids are the most abundant phenolic compounds in plants and, contrary to the previous ones, they are characterized by being a broader set of molecules, being subdivided into flavonols, flavan-3-ols, flavones, flavanones, isoflavones, flavonols and anthocyanins. Among them, kaempferol, catechin, epicatechin, apigenin, hesperetin, naringenin, genistein, cyanidin and delphinidin are the predominant ones [ 14 , 15 , 16 ]. All of them have in common the characteristic of being synthesized as plant secondary metabolites where they fulfill a wide range of biological functions.…”

Section: Phenolic Compounds In Human Healthmentioning

confidence: 99%

“…Besides, phenolics also possess antimicrobial activities. They already showed capacity to interfere with the growth of Escherichia coli H157: H7, Salmonella sp., Listeria monocytogenes and Citrobacter , with the benefit that the appearance of resistance is a less common event than in the use of conventional antibiotics [ 16 , 36 ].…”

Section: Phenolic Compounds In Human Healthmentioning

confidence: 99%

Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection

Flores-Félix

Gonçalves

Alves

et al. 2021

Foods

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The first cases of COVID-19, which is caused by the SARS-CoV-2, were reported in December 2019. The vertiginous worldwide expansion of SARS-CoV-2 caused the collapse of health systems in several countries due to the high severity of the COVID-19. In addition to the vaccines, the search for active compounds capable of preventing and/or fighting the infection has been the main direction of research. Since the beginning of this pandemic, some evidence has highlighted the importance of a phenolic-rich diet as a strategy to reduce the progression of this disease, including the severity of the symptoms. Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host’s immune response. Therefore, this review intends to discuss the most recent findings on the potential of phenolics to prevent SARS-CoV-2.

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“…Inflammation is a physiological response of the human body that aims to eliminate, neutralize and/or destroy stimuli resulting from microbial infection or tissue injury [18]. However, when it occurs exaggeratedly, it may become dangerous for host tissues, and be a precursor of many disorders, including cancer and neurological pathologies [23,24].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…Nowadays, it is already accepted that the daily ingestion of phenolic-rich sources is an effective approach to suppress these events, given their capacity to act as antioxidant species, modulate arachidonic acid metabolism (e.g., cyclooxygenase (COX), lipoxygenases and phospholipase A2), interact with pro-inflammatory nuclear factor κB, decrease the expression of inducible nitric oxide synthase (iNOS), and thus, promote a healthy state [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts

Gonçalves¹,

Costa²,

Flores-Félix³

et al. 2021

Preprint

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Cherries have been largely investigated due to their high content in phenolics in order to fully ex-plore their health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-inflammatory potential of phenolic-targeted fractions of Saco cherry, using RAW 264.7 mac-rophages stimulated with lipopolysaccharide. Additionally, the cytotoxic effects on gastric ade-nocarcinoma (AGS), neuroblastoma (SH-SY5Y) and normal human dermal fibroblast (NHDF) cells were evaluated, as well as the ability to protect these cellular models against induced oxidative stress. The obtained data revealed that cherry fractions can interfere with cellular nitric oxide (NO) levels by capturing NO radicals and decreasing inducible nitric oxide synthase and cyclooxygen-ase-2 expression. Furthermore, it was observed that all cherry fractions exhibited dose-dependent cytotoxicity against AGS cells, presenting cytotoxic selectivity for these cancer cells when compared to SH-SY5Y and NHDF cells. Regarding their capacity to protect cancer cells against oxidative injury, in most assays, the total cherry extract was the most effective. Overall, this study reinforces the sweet cherries incorporation in new pharmaceutical products, smart foods and nutraceuticals.

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Health Benefits ofPrunus aviumPlant Parts: An Unexplored Source Rich in Phenolic Compounds

Cited by 21 publications

References 190 publications

Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review

Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review

Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection

Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts

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