Health Benefits of Octacosanol and Other Long-Chain Aliphatic Fatty Alcohols from Plants

Kabir, Yearul

doi:10.1007/978-981-13-7248-3_25

Cited by 10 publications

(4 citation statements)

References 68 publications

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“…Guo et al [ 15 ] demonstrated that OCT could significantly enhance the health condition of mice, and Long et al [ 9 ] observed that dietary OCT reduced the occurrence of diarrhea in weaning piglets. Moreover, Kabir [ 8 ] reported that a natural mixture of high molecular weight alcohols, similar to OCT, showed increased anti-inflammatory activity effectively reduced chronic and acute inflammation. ILs, proteins belonging to the cytokines family, regulate inflammatory and immune responses, and increase in response to pathogens and other antigens [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…OCT products are typically a blend of long-chain aliphatic components, specifically fatty acids, aldehydes, ketones, primary and secondary alcohols, and alkanes of chain lengths C20–C36, as well as C38–C70 alkyl esters [ 4 ]. OCT has diverse biological functions including anti-fatigue properties [ 5 ], antioxidant effects [ 6 ], cholesterol-lowering effects [ 7 ], and cytoprotective features [ 8 ]. OCT isolated from rice bran has been reported to enhance growth performance, improve immunity and antioxidant levels, significantly decrease diarrhea in weanling piglets [ 9 ], induce the production of growth hormones, and up-regulate glucose transporter protein gene expressions [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary octacosanol concentration extracted from triticale sprout on laying performance, egg quality, and blood parameters of laying hens

Lim¹,

Ryu²

2022

J Anim Sci Technol

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This study was conducted to investigate the effect of dietary supplementation of octacosanol (OCT) extracted from triticale sprout on laying performance, egg quality, and blood parameters of laying hens. A total of 192, Hyline brown laying hens aged 43 weeks were divided into 4 dietary groups of 48 birds each and they were randomly subjected to one of the experimental diets containing OCT at the levels of none, 10, 20, and 30 mg/kg of diet. All birds were fed with isoenergetic and isonitrogenous mash diets for 6 weeks. The result showed that hens supplemented with 20 and 30 mg/kg OCT in diet significantly increased (p < 0.05) egg production than those fed with the basal diet. OCT concentration in the egg yolk of hens fed with 20 and 30 mg/kg OCT was significantly higher than in those fed the control diet. Hens fed 20 and 30 mg/kg OCT exhibited greater high-density lipoprotein (HDL) cholesterol and interleukin (IL) concentrations and reduced serum concentrations of cholesterol and triglyceride compared to those fed with 0 and 10 mg/kg OCT. This study indicates that supplementing the diet of laying hens with 20 and 30 mg/kg of OCT can improve the performance, egg quality, and health status of laying hens.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of dietary octacosanol concentration extracted from triticale sprout on laying performance, egg quality, and blood parameters of laying hens

Lim¹,

Ryu²

2022

J Anim Sci Technol

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“…This family of compounds has been recognized to present several biological and pharmacological effects in animals and humans. For ex-ample, octocosan-1-ol was reported to have several properties such as antioxidant activity, a cholesterol-lowering effect, lipid peroxidation, neurological functions, antiangiogenic and antitumor activity, prevention of inflammation and pain, antifatigue function, ergogenic properties, and improving athletic performance in exercise-trained rats, being used in food, medicine, and cosmetics, as reviewed by Kabir [96].…”

Section: Volatile Compoundsmentioning

confidence: 99%

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Silva

Jacinto

Coutinho

2022

Foods

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Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.

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“…Angelicin has a very effective role in curing cancer(Wang et al, 2019). Octacosane has antiplatelet, antioxidant, antiangiogenic, and neurological property due to its long alcohol chain(Kabir, 2020). Spathulenol has many properties like antioxidant, anti-inflammatory, antiproliferative and antimycobacterial (do Nascimento et al, 2018).…”

mentioning

confidence: 99%

Antibacterial, antioxidant, and phytochemical analysis of Piper longum fruit extracts against multi-drug resistant non-typhoidal Salmonella strains in vitro

Rawat

Chauhan²,

Chaudhary³

et al. 2022

JANS

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Most bacteria are becoming resistant to almost all of the currently recommended drugs, leading to difficulty in their treatment. The present study focused on evaluating the therapeutic potential of Piper longum fruit extracts in terms of bactericidal, antioxidant and phytochemical evaluation by conducting antibacterial sensitivity tests against four multidrug-resistant Salmonella strains (Salmonella enterica subsp. arizonae, Salmonella Newport, Salmonella enterica ser. Typhi, and Salmonella enterica ser. Paratyphi) obtained from the Institute of Microbial Technology (IMTECH), Chandigarh. The Agar Well Diffusion method and the Minimum Inhibitory concentration (MIC) methods were performed to implement the anti-sensitivity test of crude extracts of the plant. The present study showed that the MIC of the P. longum was between 0.25-0.0625mg/ml, which was lowest in the aqueous extract at 0.5mg/100µl, and the highest in the methanol extract (1mg/100µl). The Minimum Bactericidal Concentration (MBC) was lowest in aqueous (0.5mg/100µl) and highest in methanol plant extract (1mg/100µl). The methanol extract had the maximum antibacterial potency, whereas the aqueous extract had the lowest. The antioxidant capacity of the plant extracts was determined using a DPPH assay. Methanol plant extract revealed the highest antioxidant power (81.92%) and the lowest was found in the aqueous extract (62.84%). The GC-MS approach identified active bioingredients, important botanicals including caryophyllene, eicosane, and piperazine (potent antibacterial agent) as naphthyridine (having antimicrobial, anticancer, and anti-inflammatory activities), among others. The unique aspect of the study was the effectiveness of P. longum against Salmonella strains that are resistant to multiple antibiotics. This suggests that P. longum can be a great source of novel antibacterial compound for the development of herbal formulations.

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Health Benefits of Octacosanol and Other Long-Chain Aliphatic Fatty Alcohols from Plants

Cited by 10 publications

References 68 publications

Effect of dietary octacosanol concentration extracted from triticale sprout on laying performance, egg quality, and blood parameters of laying hens

Effect of dietary octacosanol concentration extracted from triticale sprout on laying performance, egg quality, and blood parameters of laying hens

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Antibacterial, antioxidant, and phytochemical analysis of Piper longum fruit extracts against multi-drug resistant non-typhoidal Salmonella strains in vitro

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