Health Benefits of Quercetin

Kumar, R.; Vijayalakshmi, S.; Nadanasabapathi, S.

doi:10.14429/dlsj.2.11359

Cited by 67 publications

(46 citation statements)

References 38 publications

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“…The chemical structure of quercetin consists of 15 carbon atoms with two aromatic rings connected by three-carbon bridges and three hydroxyl groups (−OH) in the position 3, 5, and 7 in hydroxychromen structure (rings A and C) and two in the position 3 and 4 in hydroxyphenyl structure (ring B; Lin & Zhou, 2018). At the biological level, health benefits have been attributed to quercetin (Kumar, Vijayalakshmi, & Nadanasabapathi, 2017), mainly to reduce the prevalence of chronic degenerative diseases such as cardiovascular diseases (Porcu et al, 2018;Terao, 2017), cancer (Granato et al, 2017;Wu et al, 2018), diabetes (Dhanya, Arya, Nisha, & Jayamurthy, 2017;Peng et al, 2017), and obesity (Nabavi, Russo, Daglia, & Nabavi, 2015;Ting et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Quercetin is a hydrophobic flavonoid with high antioxidant activity. However, for biological applications, the bioavailability of quercetin is low due to physiological barriers. For this reason, an alternative is the protection of quercetin in matrices of biopolymers as zein. The objective of this work was to prepare and characterize quercetin‐loaded zein nanoparticles by electrospraying and its study of in vitro bioavailability. The physicochemical parameters such as viscosity, density, and electrical conductivity of zein solutions showed a dependence of the ethanol concentration. In addition, rheological parameters demonstrated that solutions of zein in aqueous ethanol present Newtonian behavior, rebounding in the formation of nanoparticles by electrospraying, providing spherical, homogeneous, and compact morphologies, mainly at a concentration of 80% (v/v) of ethanol and of 5% (w/v) of zein. The size and shape of quercetin‐loaded zein nanoparticles were studied by transmission electron microscopy (TEM), observing that it was entrapped, distributed throughout the nanoparticle of zein. Analysis by Fourier transform‐infrared (FT‐IR) of zein nanoparticles loaded with quercetin revealed interactions via hydrogen bonds. The efficacy of zein nanoparticles to entrap quercetin was particularly high for all quercetin concentration evaluated in this work (87.9 ± 1.5% to 93.0 ± 2.6%). The in vitro gastrointestinal release of trapped quercetin after 240 min was 79.1%, while that for free quercetin was 99.2%. The in vitro bioavailability was higher for trapped quercetin (5.9%) compared to free quercetin (1.9%), than of gastrointestinal digestion. It is concluded, that the electrospraying technique made possible the obtention of quercitin‐loaded zein nanoparticles increasing their bioavailability. Practical Application This type of nanosystems can be used in the food and pharmaceutical industry. Quercetin‐loaded zein nanoparticles for its improvement compared to free quercetin can be used to decrease the prevalence of chronic degenerative diseases by increasing of the bioavailability of quercetin in the bloodstream. Other application can be as an antioxidant system in functional foods or oils to increase shelf life.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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“…All types of SB-based pads significantly increased the content of both quercetin and kaempferol, enhancing the nutraceutical and therapeutic values of our treated red onions (Table 4). Quercetin is known for its action on anti-proliferation, cell cycle arrest and apoptosis of cancer cells, [53][54][55] while kaempferol has multiple pharmacological uses as an antioxidant, anti-inflammatory, antimicrobial and antidiabetic and is also recognized as an important antitumor agent for its action on cancer cells from different organs. 56 Considering the glycosylated flavonols found in red onion bulbs, we observed a significant reduction in all conjugated quercetins versus an increase in the free form in red onion grown in the presence of SB alone and of SB in combination with agricultural wastes ( Table 5).…”

Section: Resultsmentioning

confidence: 99%

Sulfur bentonite‐organic‐based fertilizers as tool for improving bio‐compounds with antioxidant activities in red onion

et al. 2019

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BACKGROUND Red onion is popular in cuisines worldwide and is valued for its potential medicinal properties. Red onion is an important source of several phytonutrients such as flavonoids, thiosulfinates and other sulfur compounds, recognized as important elements of the diet. Nowadays, there is the need of producing food enriched in health benefit compounds. In this study, pads of sulfur bentonite (SB) with the addition of orange residue (OR) or olive pomace (OP) were used to improve the quality of red onion. The experiment was conducted for 3 months in the field to evaluate the phytochemicals of differently amended red onion. RESULTS Treated plants were better in quality than controls. Antioxidant activity, detected as DPPH, ORAC and ABTS, was highest in plants grown in the presence of SB enriched with agricultural wastes, particularly SB‐OR. Polyphenols increased in all treated plants. The volatile fraction was clearly dominated by sulfur compounds that are strictly related to the concentration of the aroma precursors S‐alkenyl cysteine sulfoxides. The greater amount of thiosulfinates in treated compared with untreated onion evidenced that SB pelletized with agricultural wastes can represent a new formulation of organic fertilizer able to improve the beneficial properties of onion. The results highlighted that the best red onion quality was obtained using SB‐OR pads. CONCLUSION The use of SB bound with agricultural wastes represents a novel strategy to increase bio‐compounds with beneficial effects on human health, to enhance the medical and economic values of sulfur‐loving crops, with important consequences on the bio and green economy. © 2019 Society of Chemical Industry

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“…Kuersetin merupakan flavonoid yang diklasifikasikan ke dalam golongan flavonol yang paling berlimpah terkandung dalam buah-buahan dan sayuran (Wach et al, 2007). Kuersetin memiliki banyak manfaat bagi kesehatan diantaranya seperti antioksidan dengan menangkal radikal bebas, sariawan, efek neurologis, aktivitas antivirus, antiinflamasi, asma, aktivitas kardiovaskular, agen antikanker, antialergi, dan antimelanogenesis (Choi dan Shin, 2016;Kumar et al, 2017).…”

Section: Pendahuluanunclassified

“…Ekstraksi kuersetin dari daun kelor dilakukan dengan menggunakan pelarut metanol karena sifatnya yang sangat larut dalam metanol dan dapat memberikan hasil ekstraksi yang terbaik (Dmitrienko et al, 2012;Kumar et al, 2017). Dalam sampel bahan alam, kuersetin tidak hanya terdapat dalam bentuk bebasnya, tetapi juga dalam bentuk terikat sebagai glikosida.…”

Section: Hasil Dan Pembahasanunclassified

OPTIMASI METODE EKSTRAKSI KUERSETIN DARI DAUN KELOR (Moringa oleifera L.)

Laksmiani

Widiantara

Adnyani

et al. 2020

JCHEM

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Moringa plants is very abundant in Indonesia. Moringa leaves are a source of polyphenol compounds, namely flavonoids. One of the main flavonoids found in Moringa leaves is quercetin. To be able to increase the concentration of quercetin from moringa plants, extraction is necessary. This study aims to determine the most optimal extraction method in extracting quercetin from Moringa leaves. Optimization of quersein extraction methods from Moringa leaves was carried out using maceration, soxhletation, and reflux methods. The solvent used was methanol acidified with 1,2 N HCl. Determination of the concentration of quercetin in the extract used a validated TLC-densitometry method. The highest rendement obtained from the maceration extraction method was 24.08 % w/w. Extraction by reflux and sochletation methods yielded rendement of 23.44 % w/w and 10.12 % w/w respectively. Qualitative analysis of quercetin in the extract was carried out by comparing its Rf value with the standard quercetin which is 0,4. The quercetin level of the extract from maceration extraction was the highest, which was 24.45 % w/w. Extraction using the soxhletation method obtained quercetin as much as 20.95 % w/w. Keywords: quercetin, Moringa oleifera leaves, extraction method, optimization

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Health Benefits of Quercetin

Cited by 67 publications

References 38 publications

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Sulfur bentonite‐organic‐based fertilizers as tool for improving bio‐compounds with antioxidant activities in red onion

OPTIMASI METODE EKSTRAKSI KUERSETIN DARI DAUN KELOR (Moringa oleifera L.)

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