Health effects of short-term inhalation of nitrogen dioxide and ozone mixtures

Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants

“…This study has demonstrated that exercise exposure can greatly modify the interactive toxic effects of combined air pollutants on respiratory tract tissues. While human pulmonary function studies have not found evidence for strong interactions between the oxidants O 3 and NO 2 (Hackney et al, 1975;Folinsbee et al, 1981;Kagawa, 1983), synergistic and additive interactions have been demonstrated at the biochemical level and in resistance to bacterial infection in animal studies (Ehrlich et al, 1977;Watanabe et al, 1980;Mustafa et al, 1984;Graham et al, 1987). In the present study, synergism was demonstrated at the tissue level as lung parenchymal inflammatory lesions.…”

Effects of NO 2 on Chronic Bronchitics

“…More recent findings indicate that exposures to NO2 at low concentrations will cause a significant increase in the mortality of mice challenged with streptococcus aerosol after exposure to the pollutant. The same effect was seen at even lower pollutant levels when mixtures of NO2 and 03 at concentrations frequently found in ambient air were used (27,28).…”

The effects of gaseous air pollutants on peroxidative metabolism in mouse lungs.

“…Although ozone and nitrogen dioxide were not mixed in this study, both pollutants have acted additively in the same manner when mixtures were used40, 43,44). A synergistic effect upon repeated exposure to a mixture44) was not observed here.…”