Health, growth and reproductive success of mice exposed to environmentally relevant levels of Ra-226 via drinking water over multiple generations

Walsh, Stephanie; Satkunam, Meloja; Su, Ben; Festarini, Amy; Bugden, Michelle; Peery, Harry E.; Mothersill, Carmel; Stuart, Marilyne

doi:10.3109/09553002.2015.1028598

Cited by 5 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experiments using 18 generations of exposed mice with the daily dose about 0.29 mGy suggested that low-dose low-rate exposures do not affect the sex ratio in mouse litters [43]. No radiation-induced sex ratio changes in the offspring of mice were found by other researchers [44][45][46][47][48]. Note that doses applied in animal experiments are much higher than average doses to the residents of contaminated territories after the Chernobyl accident.…”

Section: Issn: 2471-4879mentioning

confidence: 89%

The Sex Ratio at Birth: The Role of Ionizing Radiation Vs. Social Factors

Jargin

2023

J Environ Stud

View full text Add to dashboard Cite

Section: Issn: 2471-4879mentioning

confidence: 89%

The Sex Ratio at Birth: The Role of Ionizing Radiation Vs. Social Factors

Jargin

2023

J Environ Stud

View full text Add to dashboard Cite

“…Experiments using 18 generations of exposed mice with the daily dose ∼0.29 mGy suggested that low-dose low-rate exposures do not affect the sex ratio in mouse litters [14]. No radiation-induced sex ratio changes in the offspring of mice were found by other researchers [15][16][17][18][19]. On the contrary, a study and review from the year 1968 concluded that there is a sex ratio shift following spermatogonial exposure in rats [20].…”

Section: Introductionmentioning

confidence: 99%

Male to Female Ratio at Birth: the Role of Background Radiation vs. Other Factors

2018

J Environ Stud

View full text Add to dashboard Cite

“…Experiments using 18 generations of exposed mice with the daily dose ∼0.29 mGy suggested that low-dose low-rate exposures do not affect the sex ratio in mouse litters [10]. No radiation-induced sex ratio changes in the offspring of mice were found by other researchers [11][12][13][14][15]. On the contrary, a study and review from 1968 concluded that there is a sex ratio shift following spermatogonial exposure in rats [16].…”

mentioning

confidence: 99%

Letter to the Editor

Jargin

2016

JRS

View full text Add to dashboard Cite

Dear Editor, The impact of radiation exposures from nuclear testing [1] and Chernobyl fallout [2,3] on the male to female ratio at birth has been discussed by Victor Grech, professor at the Department of Pediatrics, Mater Dei Hospital, Malta. However, social factors that could have influenced this ratio were not comprehensively analyzed. The natural radiation background was not mentioned, although additional doses due to the contamination were often negligible compared to doses from the background. Worldwide annual exposures to natural radiation sources are generally expected to be in the range of 1-10 mSv, with 2.4 mSv being the estimate of the central value [4]. The six million residents of the contaminated territories of Belarus, Russia and Ukraine received average individual whole body doses around 9 mSv for the period 1986-2005. For the 98 million people in the three republics, the average dose was 1.3 mSv, a third of which was received in 1986. This is a minor addition to the dose from the global average background radiation for the same period, which is approximately 50 mSv [5]. In other countries, individual doses from the Chernobyl fallout were lower: the first year doses after the accident reached 1 mSv only at singular locations in Central Europe; all country overages were below 1 mSv [6]. The maximum annual dose from the global fallout was estimated to be 0.14 mSv in 1963, having decreased by almost an order of magnitude by 1979. Reported annual individual doses from a number of reactor sites have been in the range 0.001-0.5 mSv [4], so that these dose comparisons pertain also to the reported shift of sex ratios at birth in the vicinity of nuclear facilities [7]. For comparison, a single computed tomographic (CT) examination produces a dose within the range 2-20 mSv, while doses from interventional diagnostic procedures usually range from 5 to 70 mSv [8]. Health risks have never been proven for the above-mentioned doses; an overview is in [9].Experimental and other relevant research has not been discussed in [1][2][3]. The following studies should be cited in this connection. Experiments using 18 generations of exposed mice with the daily dose ∼0.29 mGy suggested that low-dose low-rate exposures do not affect the sex ratio in mouse litters [10]. No radiation-induced sex ratio changes in the offspring of mice were found by other researchers [11][12][13][14][15]. On the contrary, a study and review from 1968 concluded that there is a sex ratio shift following spermatogonial exposure in rats [16]. It should be commented that doses used in animal experiments are higher than average doses to the residents of contaminated areas after the Chernobyl accident. These latter doses are generally within "the window for maximum adaptive response protection" [17]. According to experimental data, this window occurs at doses between 1 and 100 mGy from a low dose rate, low LET radiation exposure, where the risk is expected to be reduced below the spontaneous level of cancer risk [17]. Finally, data on the total number...

show abstract

Health, growth and reproductive success of mice exposed to environmentally relevant levels of Ra-226 via drinking water over multiple generations

Abstract: Based on the endpoints measured on four generations of mice, there is no indication that the consumption of radium-226 via drinking water (at activity concentrations up to 8.0 Bq/l) affects health, growth and reproductive fitness.

Cited by 5 publications

References 20 publications

The Sex Ratio at Birth: The Role of Ionizing Radiation Vs. Social Factors

The Sex Ratio at Birth: The Role of Ionizing Radiation Vs. Social Factors

Male to Female Ratio at Birth: the Role of Background Radiation vs. Other Factors

Letter to the Editor

Contact Info

Product

Resources

About