An integral analysis of Air Pollution in the Gulf of Mexico was made considering pollutants emissions assessment and diagnosis; air pollution monitoring; and modeling of air pollution dispersion. Combustion sources considered in this work were: thermoelectric power plants and open flares; and pollutants considered were sulfur dioxide, nitrogen dioxides, particulate matter (PM 10 and PM 2.5 ), Total suspended particles (TSP) and carbon monoxide (CO). This study made evident a lack of more recent information and a homogenization in emissions factors in order to know the conditions of air pollution in the Gulf of Mexico in a more reliable way.