Health impacts of second‐hand exposure to cat allergen Fel d 1 in infants

Heissenhuber, Alois; Heinrich, Joachim; Fahlbusch, B; Borte, Michael; Wichmann, HE; Bolte, Gabriele

doi:10.1034/j.1398-9995.2003.00037.x

Cited by 31 publications

(21 citation statements)

References 15 publications

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“…Pet allergen is mainly carried into classrooms on the garments of pet owners, and the amount of cat allergen in a school has been shown to be proportional to the number of cat owners in class [30]. "Second-hand" cat allergen exposure has been suggested to be an important contributor to allergic sensitization and atopic disease among non-pet owners [31,32]. One prospective Swedish study investigated the effect of student clothing on classroom cat allergen levels.…”

Section: Exposure Mitigationmentioning

confidence: 99%

Home and school environmental assessment and remediation

Lupoli

Ciaccio²,

Portnoy³

2009

Curr Allergy Asthma Rep

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Children spend a considerable portion of their time indoors. Therefore, homes and schools are an important source of allergen exposure. Chronic exposure to the major indoor allergens can lead to allergic sensitization and provoke allergic symptoms in children. Environmental assessment is crucial for the identification and quantification of such allergens in indoor spaces. Reduction of allergen exposure below sensitization and symptom thresholds is possible with various remediation techniques. This article reviews and discusses evidence for the assessment and remediation of indoor allergens commonly found in homes and schools. A literature review was performed using the PubMed database for English-language articles published between January 1, 1980, and February 2009. Additional information was obtained from a review of recent textbooks and one professional society's webpage.

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Section: Exposure Mitigationmentioning

confidence: 99%

Home and school environmental assessment and remediation

Lupoli

Ciaccio²,

Portnoy³

2009

Curr Allergy Asthma Rep

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“…[11][12][13][14][15][16] Longitudinal studies in schoolchildren instead found no association or even an inverse association between cat ownership and cat sensitization. 17,18 In adults, a strong positive association between cat ownership at baseline and incidence of cat sensitization was reported by a Danish study.…”

mentioning

confidence: 93%

Risk factors for new-onset cat sensitization among adults: A population-based international cohort study

Olivieri

Zock

Accordini

et al. 2012

Journal of Allergy and Clinical Immunology

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“…Liccardi et al demonstrated that even a low level of cat allergen induced a stronger cutaneous hypersensitivity response compared with direct exposure to cats [34]. Other studies have also shown that the low levels of cat allergens found in homes without cats can induce allergic sensitization and respiratory symptoms [35][36][37]. Even in environments without cats, such as cat-free buildings [38], public buildings [39], public transport [39,40], and primary schools [41], passive exposure to low allergen levels could lead to sensitization.…”

Section: Discussionmentioning

confidence: 96%

Specific IgG for cat allergens in patients with allergic conjunctivitis

et al. 2014

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Immunoglobulin G (IgG) antibodies are involved in type II and type III hypersensitivity. We evaluated the relation between perennial allergic conjunctivitis and serum levels of specific IgG for cat allergens. A prospective study was conducted in patients with seasonal allergic conjunctivitis (seasonal group, n = 10), patients with perennial allergic conjunctivitis (perennial group, n = 10), and healthy control subjects (control group, n = 10). Serum levels of specific IgE and IgG for cat allergens and total tear IgE were measured, and a skin prick test was also performed. In addition, a severity score associated with allergic conjunctivitis was calculated (0-30). The positive rates and scores of for total tear IgE, serum cat-specific IgE, and serum cat-specific IgG were all higher in the seasonal and perennial groups than in the control group (all p < 0.05). Serum cat-specific IgG levels were higher in the perennial group than in the seasonal group (p = 0.0156), but there was no significant difference in the grade of cat-specific IgE between the two groups (p = 0.3008). On multivariate analysis, the mean wheal diameter for cat allergen was associated with the serum level of cat-specific IgG (not IgE) in all patients [odds ratio (OR) = 31.979, p < 0.0001]. Multivariate analysis revealed that the total objective score was strongly associated with serum cat-specific IgG (OR = 23.015, p < 0.0001). These findings suggest that specific IgG antibodies may be involved in perennial allergic symptoms caused by indoor allergens such as cat allergens.

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Health impacts of second‐hand exposure to cat allergen Fel d 1 in infants

Abstract: Second-hand exposure to cat allergen in homes without cats is detrimental in terms of allergy development in infants.

Cited by 31 publications

References 15 publications

Home and school environmental assessment and remediation

Home and school environmental assessment and remediation

Risk factors for new-onset cat sensitization among adults: A population-based international cohort study

Specific IgG for cat allergens in patients with allergic conjunctivitis

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