Health Informatics of Doxofylline Combined with Penehyclidine Hydrochloride on Pulmonary Inflammation in Chronic Obstructive Pulmonary Disease Based on ANOVA Statistical Analysis

Abstract

Objective: This study evaluated the effect of doxofylline combined with penehyclidine hydrochloride on the pulmonary inflammatory response during mechanical ventilation in chronic obstructive pulmonary disease (COPD), as well as to identify the effects of JNK/SAPK signaling pathway in this inflammatory response. Methods: The COPD model can be constructed by exposing it to cigarette smoke and injections of lipopolysaccharide into the airway. Rats were selected randomly for treatment with doxofylline, penehyclidine hydrochloride, a combination of these two drugs. The control Group received no drug treatment. The date were processed using ANOVA statistical analysis. Results: In all rats, the lung tissue was pathologically characteristic of COPD. Peak airway pressure, the wet/dry weight of lungs, and degrees of TNF-α, IL-10, malondialdehyde, JNK, and p-JNK decreased; while IL-10 and superoxide dismutase levels increased (p < 0.05) in all Groups having received drug treatment (p < 0.05) when compared to control. The combination of penehyclidine hydrochloride with doxofylline had a stronger effect on all of these metrics than either drug alone (p < 0.05). Conclusion: Based on health informatics, This study suggests that the combination of penehyclidine hydrochloride with doxofylline can promote the recovery and maintenance of immune homeostasis in mechanically ventilated COPD rats, and that the underlying mechanism may be is influenced by downregulation of the JNK/SAPK signaling pathway.