This chapter explored literature and discussed the importance of knowledge sharing practices, ICT, and information literacy, and their influence on STEM career path choices among girls at the secondary school level. This was properly situated by examining the concept of knowledge sharing, concept of career path choices, knowledge sharing on career path choices of girls, considered ICT and career path choices of girls, effect of ICT on career path choices of girls, information literacy and career path choices of girls, effect of information literacy on career path choices of girls. It concludes that a culture of knowledge sharing practices among the girls will get the less knowledgeable girls informed for informed STEM career path decisions. The use of ICTs for networking and sharing knowledge among the girls will improve information literacy skills needed by the girls to help identify information needs, access, retrieve, evaluate, and use same career choices. The chapter includes recommendations.