The concept of knowledge management formed at the end of the 20th century. At the same time, the vector of this concept is evolving due to the emergence of new business models, technologies, and the recognition of the “soft” components of success or the so-called “soft skills”, and changes in the strategies of organizations.The article is a systematic scientific review, the purpose of which is to identify the mainstream in the field of economics and knowledge management. The methodology of the article is based on a set of approaches, including the knowledgebased theory of the firm, the concepts of knowledge engineering, organizational learning, dynamic capabilities and knowledge transformation, etc., and the research methodology is based on taxonomic and cluster analysis of the most cited English-language publications using tools embedded in the VOSviewer software product. The information base consisted of articles for 2018–2024, selected according to the research topic and keywords “Knowledge Management”, and placed in the Dimensions database. As a result, we identified 6 clusters and formalized the directions of modern research in the field of knowledge management. In each cluster, a content analysis of the most cited articles was carried out. The research agenda is currently focused on two main issues: the impact of digitalization and digital technologies on the choice, generation and dissemination of knowledge in an organization; the impact of knowledge on innovation as a mediator of business performance, including its environmental and social aspects. In fact, a consensus has been found in understanding the basic postulates of the concept of knowledge management. However, the problem of finding the “good” metrics for assessing the knowledge of an organization and the impact of their level on business performance remains relevant. It is shown that among the theoretical frameworks in knowledge management, the most popular are knowledge engineering and knowledge-based theory of the firm. The results of the study will be useful to managers-practitioners and researchers in the development of effective knowledge management systems.