Health promoting benefits of postbiotics produced by lactic acid bacteria: Exopolysaccharide

Gezginç, Yekta; Karabekmez-Erdem, Tuğba; Tatar, Hazel Dilşad; Ayman, Sermet; Ganiyusufoğlu, Eda; Dayısoylu, Kenan Sinan

doi:10.38042/biotechstudies.1159166

Cited by 18 publications

(5 citation statements)

References 68 publications

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“…Postbiotics, on the other hand, are the metabolic byproducts of beneficial bacteria that exhibit various health-promoting effects. These include antimicrobial activity against pathogens, modulation of immune responses, and enhancement of gut barrier function [274][275][276].…”

Section: Innovative Treatment Strategies Targeting the Microbiomementioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

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Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.

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Section: Innovative Treatment Strategies Targeting the Microbiomementioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

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show abstract

“…Centrifugation is the first stage in a multiphase method to extract EPSs, which also includes acid protein removal, cold ethanol precipitation, filtration to remove small molecules, dialysis, and lyophilization [ 129 ]. EPSs are essential for cell adhesion and defense, and the structural diversity of EPSs produced by lactic acid bacteria (LAB) enables polymers to have a range of bioactivities, including immunomodulatory, antitumor, antimutagenicity, antioxidant, anti-inflammatory, antihypertensive, antibacterial, antiviral, cholesterol-lowering, and anti-gastrointestinal activities [ 130 ]. Khalil et al [ 131 ] reported that EPS generated from Lactobacillus strains showed antibacterial and antioxidant activities and improved lipid metabolism by inhibiting cholesterol absorption.…”

Section: Classification Of Postbioticsmentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced by microorganisms that exert biological effects on the hosts”; and (iii) “compounds produced by microorganisms, released from food components or microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health and wellbeing”. A probiotic- and prebiotic-rich diet ensures an adequate supply of these vital nutrients. During the anaerobic fermentation of organic nutrients, such as prebiotics, postbiotics act as a benevolent bioactive molecule matrix. Postbiotics can be used as functional components in the food industry by offering a number of advantages, such as being added to foods that are harmful to probiotic survival. Postbiotic supplements have grown in popularity in the food, cosmetic, and healthcare industries because of their numerous health advantages. Their classification depends on various factors, including the type of microorganism, structural composition, and physiological functions. This review offers a succinct introduction to postbiotics while discussing their salient features and classification, production, purification, characterization, biological functions, and applications in the food industry. Furthermore, their therapeutic mechanisms as antibacterial, antiviral, antioxidant, anticancer, anti-diabetic, and anti-inflammatory agents are elucidated.

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“…EPS are essential for cell adhesion and defence. The structural diversity of EPS produced by lactic acid bacteria (LAB) enables the polymers to have a range of bioactivities, including immunomodulatory, antitumor and antimutagenicity, antioxidant, anti-inflammatory, antihypertensive activity, antibacterial and antiviral, cholesterol-lowering, and anti-gastrointestinal activity (Gezginç et al, 2022). According to Khalil et al (2018), EPS generated from Lactobacillus strains showed antibacterial and antioxidant activities and improved lipid metabolism by inhibiting cholesterol absorption.…”

Section: Exopolysaccharidesmentioning

confidence: 99%

Postbiotics- Functional Food Materials

Gurunathan,

Thangaraj,

Kim

2023

Preprint

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Postbiotics are biologically active probiotic microorganisms that have produced non-viable bacterial products in the host. Eating a diet high in probiotic and prebiotic foods may help to ensure that the gut has an appropriate supply of these essential nutrients because postbiotics are produced when probiotics feed on prebiotics. Cell wall components and metabolites produced by living bacteria that have positive effects on the host are referred to as postbiotics. Postbiotics are functional bioactive chemicals that are produced in a matrix during anaerobic fermentation of organic nutrients like prebiotics. Postbiotics are low molecular weight soluble chemicals that are either produced after microbial cell lysis or secreted by live microflora as byproducts of this metabolic process. In general, the producer strains from bacterial and fungal species such as Lactobacillus, Bifidobacterium, Streptococcus, Akkermansia muciniphila, Saccharomyces boulardii, Eubacterium hallii, Faecalibacterium, etc. When handling and selling food items in an industrial setting, postbiotics can be used as functional components in foods, which has a number of advantages, including the potential to be added to some foods that are known to be harmful to probiotic survival. Postbiotic supplements have grown in popularity among customers because of their numerous health advantages, particularly food, cosmetic, and healthcare industries. Classification of postbiotics depends on various factors including type of microorganism, structural composition, and physiological functions. This review presents a succinct introduction, history, and concept of postbiotics, the salient features of postbiotics, classification, production, purification, characterization, biological functions, and applications of postbiotics in the food industry.

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Health promoting benefits of postbiotics produced by lactic acid bacteria: Exopolysaccharide

Cited by 18 publications

References 68 publications

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Postbiotics- Functional Food Materials

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