Health related quality of life in patients with Cohn's disease in remission

Abstract

Background: Crohn's disease (CD) affects Health Related Quality of Life (HRQoL) especially in patients with clinical activity but their impact over the disease during periods of remission has not been sufficiently studied. Objective: To evaluate HRQoL in CD patients in remission and to identify socio-demographic and clinical factors related. Methods: We included patients with CD in remission for at least 6 months, defined as a CDAI < 150 and a CRP < 5 mg/L. Socio-demographic and clinical parameters were recorded. HR-QoL was evaluated with Short Form 36 Questionnaire (SF-36) and the Inflammatory Bowel Disease Questionnaire (IBDQ). Results were analyzed using multiple regressions with a confidence interval of 95%. Results: Nine two patients (X-= 37 ± 11.4 years, 52.2% men) were consecutively included. Two patients failed to fill correctly the questionnaire and were excluded. Scores on the SF-36 were lower than in the general population of similar age and gender. The most affected dimension in the SF-36 was General Health (47.98 ± 19.58) and the IBDQ Systemic Symptoms (5.15 ± 1.27). Age, colonic location and previous surgery was related with worse HRQoL, while higher educational status, more time since diagnosis, steroid-resistance and inflammatory behavior, was associated with better HRQoL. Conclusions: Despite being in remission, CD patients had affected their HRQoL, so we must continue working to achieve improvement in HRQL of these patients during these periods of the disease.

Inflammatory Bowel Disease: Impact on Scores of Quality of Life, Depression and Anxiety in Patients Attending a Tertiary Care Center in Brazil

“…(data not shown). and 152.7±46.9, respectively, a result similar who obtained mean scores (±SD) of 177.6±39.6 for CD and 178.5±35.3 for UC, but in contrast to IGLESIAS et al (20) in which patients with CD had lower scores in all domains of the SF-36 and low scores in the Systemic Symptoms section of the IBDQ.…”

Psychological Factors Are Associated with Changes in the Health-related Quality of Life in Inflammatory Bowel Disease

“…44,45 Contrary to what was expected, no association was found between the form of coping with stress and HRQOL, unlike what was seen in previous studies on patients with IBD. 16 Regarding the importance of sociodemographic and clinical variables, the results once again point out the role of age, 48 extraintestinal manifestations, the presence of an exacerbation, and the number of previous recurrences on HRQOL. In fact, these same results were obtained in previous studies where in addition to coping, they also evaluated the presence of psychological comorbidity in patients on peritoneal dialysis 47 and patients with IBD.…”

Associations between disease activity, social support and health-related quality of life in patients with inflammatory bowel diseases: the mediating role of psychological symptoms

“…The total score for both anxiety and depression subscales range between 0 and 21. Using the HADS, depression and anxiety can be categorized into four levels as follows: normal (0-7), mild (8-10), moderate (11)(12)(13)(14)(15), and severe (16)(17)(18)(19)(20)(21). The total Fig.…”

“…Improvement of HRQoL can be achieved by diminishing disease activity or inducing remission. However, there was still a large number of IBD patients reporting low HRQoL despite being in remission [9,20], signifying a possibility of other underlying determinants.…”