Health-related quality of life among patients with facial acne − assessment of a new acne-specific questionnaire

Martin, Allison R.; Lookingbill, Donald P.; Botek, Alison A.; Light, Jennifer; Thiboutot, Diane; Girman, C. J.

doi:10.1046/j.1365-2230.2001.00839.x

Cited by 119 publications

(114 citation statements)

References 20 publications

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“…12 Measurement of QOL is done with validated and reliable questionnaires like Dermatology Life Quality Index( DLQI),Acne Disability index(ADI),and Cardiff Acne Disability Index( CADI) . 13 Assessing quality of life can help provide patients with better service, by acknowledging their real needs and interfering with treatment decisions.…”

Section: Introductionmentioning

confidence: 99%

Acne and Quality of Life- A Study from a Tertiary Care Centre in South India

Samanthula¹

2013

IOSR-JDMS

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Section: Introductionmentioning

confidence: 99%

Acne and Quality of Life- A Study from a Tertiary Care Centre in South India

Samanthula¹

2013

IOSR-JDMS

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“…35,36 As further investigations have been carried out to enlighten the pathogenesis of acne, newer treatment options in the management of this intricate disease have emerged. 16,37 OS is one of the mechanisms regarded as being responsible for the development of acne vulgaris.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Isotretinoin on Oxidative Stress in Severe Acne Vulgaris Patients

Yorulmaz¹,

Metin²,

Işıkoğlu³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Oxidative stress (OS) has been implicated in the pathogenesis of a variety of diseases including acne vulgaris. Isotretinoin (Iso), which is accepted to be the most effective medication in the treatment of nodulocystic acne, has a number of adverse effects related to OS. The aim of this study was to enlighten the disputed role of OS in the pathogenesis of acne and the effects of Iso on OS. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Fifty patients with nodulocystic acne who were receiving Iso and fifty healthy controls were included in the study. Blood samples were obtained from patients before and on the 45 th day of treatment and once from the controls. Serum total oxidant status (TOS), total antioxidant capacity (TAC) levels were measured spectrophotometrically and oxidative stress index (OSI) was calculated as a ratio of TOS to TAC. R Re es su ul lt ts s: : Before Iso, serum TOS levels and OSI values were significantly lower in the patients compared to the controls (p=0.004 and p=0.006, respectively). On the other hand, there was no statistically significant difference between the groups for TAC levels (p=0.285). When the values of patients before and after the treatment were compared, it was revealed that serum TOS levels and OSI values had significantly increased (p=0.035 and p=0.043, respectively), yet, TAC levels were not statistically different (p=0.308). C Co on nc cl lu us si io on n: : These results suggest that OS is decreased in patients with acne. Besides, Iso's exact mechanism of action on OS remains somewhat obscure. Further studies are required to clarify the relationship between acne, Iso and OS.K Ke ey y W Wo or rd ds s: : Acne vulgaris; isotretinoin; oxidative stress Ö ÖZ ZE ET T A Am ma aç ç: : Oksidatif stres (OS) akne vulgaris de dahil olmak üzere birçok hastalığın patogenezinde suçlanmıştır. Nodülokistik akne tedavisinde en etkili ilaç olarak kabul edilen izotretinoin (İzo), OS ile ilişki çok sayıda yan etkiye sahiptir. Bu çalışmanın amacı akne patogenezinde OS'nin rolünü ve İzo'nun OS üzerindeki etkilerini ortaya koymaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmaya İzo tedavisi alan 50 nodülokistik akne hastası ve 50 sağlıklı kontrol dahil edildi. Kan örnekleri hastalardan tedavinin öncesinde ve 45. gününde; kontrollerden ise bir kez alındı. Serum total oksidan seviye (TOS) ve total antioksidan kapasite (TAK) spektrofotometrik yöntemle ölçüldü; TOS'un TAK'a oranı kullanılarak da oksidatif stres indeksi (OSİ) hesaplandı. B Bu ul lg gu ul la ar r: : Kontrol grubu ile karşılaştırıldığında, İzo öncesinde hastaların serum TOS seviyeleri ve OSİ değerleri anlamlı derecede düşük tespit edildi (sırasıyla p=0,004 ve p=0,006). Bunun aksine, TAK düzeyleri göz önünde bulundurulduğunda iki grup arasında istatistiksel olarak anlamlı bir fark yoktu (p=0,285). Tedavi öncesine göre sonrasında ise, serum TOS düzeylerinin ve OSİ değerlerinin anlamlı derecede arttığı (sırasıyla p=0,035 ve p=0,043), ancak TAK sev...

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“…First, validity of our TTO utility measures for current acne state as well as WTP for never having acne is supported by their strong correlation with scores from the total Acne-QOL, a validated acne-specific QOL instrument. 24 Second, our self-administered paper instrument is a practical method for assessing TTO and WTP for current health state as well as hypothetical outcomes. Third, adolescents in the community are capable of understanding the preference scenarios and making utility valuations in this manner.…”

Section: Commentmentioning

confidence: 99%