The psychosocial effects of facial acne are well accepted but until recently few validated instruments existed which were suitable for use in clinical trials. The aim of this study was to assess measurement characteristics (reproducibility, correlation with acne severity, and sensitivity to detect change after acne therapy) of a new acne-specific quality of life instrument, the Acne-QoL. We found that the Acne-QoL is reliable, valid and able to distinguish differences across severity groups and improvement over 16 weeks of standard therapy. The use of the Acne-QoL should aid physicians in understanding the impact of facial acne on young adults, and may be useful in assessing therapeutic effects in acne clinical trials.

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We attempted to clarify the anatomic relationships of the lacrimal sac by performing standard orbital dissections to expose the lacrimal canaliculi, lacrimal sac, the ethmoid air cells, nasal septum, frontal sinuses, and the cribriform plate in five human cadaver heads; and then measuring the distance between the internal common punctum (ICP) and five key structures. The mean vector distance from the ICP to the anterior aspect of the cribriform plate was 25.1 ± 2.95 mm. This measurement, along with the others, helps clarify osteotomy placement for dacryocystorhinostomy, so that, for example, cerebrospinal fluid leak can be prevented. Improved understanding of the anatomy of this region is also valuable in planning surgery for orbital and nasoorbital tumors, trauma, and congenital abnormalities.