Health-related quality of life assessed by LupusQoL questionnaire and SF-36 in Turkish patients with systemic lupus erythematosus

Abstract

The LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus. We conducted this study to compare the efficiency of LupusQoL-TR (validated Turkish version of the LupusQoL questionnaire) with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Turkish patients with lupus. Both questionnaires were conducted at a single visit to the clinic. Disease activity was measured with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Associations between the LupusQoL-TR and SF-36 domains were examined while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman's correlation coefficients, and Students t test were performed to analyze the data. A total of 113 consecutive patients with lupus (F/M 108:5, mean age 40.6 ± 11.9 years, mean disease duration 8.5 ± 7.0 years) were included, and 69 % of these were active. The median SLEDAI score was 2 (0-24), the mean global LupusQoL-TR score was 60.9 ± 23.3, and the mean SF-36 score was 41.2 ± 9.0. There was a significant correlation between LupusQoL-TR and SF-36 mean scores (r = 0.83; p < 0.001). QoL assessed by LupusQoL-TR and SF-36 did not correlate with disease activity (r = -0.11; p = 0.244 and r = -0.03; p = 0.721, respectively). LupusQoL-TR and SF-36 questionnaires were beneficial instruments in evaluating HRQoL in Turkish lupus patients. However, LupusQoL-TR and SF-36 were not associated with SLEDAI scores, which suggested that QoL might be affected by other factors besides disease activity, especially in clinically inactive or mildly active patients.

Health and quality of life outcomes impairment of quality of life in type 2 diabetes mellitus: a cross-sectional study

“…A multivariate logistic model was built to control for confounding variables. The association of factors with inadequate global HRQoL [26, 27] was determined using odds ratios (ORs) and 95% confidence intervals (95% CIs). All analyses were performed using SPSS version 12.0 (Chicago, IL, USA).…”

Quality of life and influencing factors of coal miners in Xuzhou, China

“…Quality of life (QOL) is a multidimensional concept that contains physical, physiological, social heath and individual's satisfaction, and is widely accepted as an important end point in medical care (7,8). The 36-item Short-Form Health Survey (SF-36) questionnaire has been applied widely to assess QOL of people in many areas and studies (9)(10)(11)(12)(13). For example, a study which used SF-36 showed that the health-related quality of life (HRQL) of electric welders was significantly lower than ordinary people (14).…”

Patient-Reported Outcomes in Systemic Lupus Erythematosus

“…Originally developed in the U.K. [39], the instrument has since been validated in a United States (U.S.) sample of SLE patients [64]. Validity and other psychometric properties of non-English translations of LupusQoL have been published for Spanish [65], Turkish [66, 67], Persian [68], Italian [69], French [70], and Chinese [71] language cohorts. LupusQoL evaluates eight domains including physical health, pain, planning, intimate relationships, burden to others, emotional health, body image, and fatigue.…”