Health‐related quality of life associated with different cancer treatments in Chinese breast cancer survivors in Taiwan

Ou, Horng Yih; Chung, Wei Pang; Su, Pei Fang; Lin, Tzu Hsuan; Lin, Ji; Wen, Yu-Chieh; Fang, Wei

doi:10.1111/ecc.13069

Cited by 15 publications

(20 citation statements)

References 45 publications

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“…Breast is a special symbol of women's beauty and every woman wants to be beautiful". Although the results were not statistically signi cant due to small sample size, it is consistent with previous ndings of original studies and systematic reviews with meta-analysis [30,33,31,[34][35][36].…”

Section: Eq-vas Scores and Utility Scoressupporting

confidence: 90%

Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Ngan

Quynh

Minh

et al. 2020

Preprint

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Background This study compared the health-related quality of life (HRQoL) of BC patients, survivors, and age-matched women from the general population in Vietnam in order to address the paucity of HRQoL research and contribute to the robust assessment of breast cancer (BC) screening and care in Vietnam. Methods The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms Study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. Results A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected most the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. Conclusions The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

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Section: Eq-vas Scores and Utility Scoressupporting

confidence: 90%

Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Ngan

Quynh

Minh

et al. 2020

Preprint

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“…One duplicate study was identified which reports the same patient sample (personal communication) and values, the most recent paper has been included in the analysis [ 19 , 20 ]. Five studies met the eligibility criteria [ 20 – 24 ]. A PRISMA flow diagram is shown in Fig 1 .…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of health state utility values measured by EuroQol 5-dimensions (EQ5D) questionnaire in Chinese women with breast cancer

Rautenberg

Hodgkinson

Zerwes³

et al. 2022

BMC Cancer

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Background To synthesise EQ5D health state utility values in Chinese women with breast cancer for parameterising a cost utility model. Methods Eligible studies had to report health state utility values measured by EQ-5D in Chinese women diagnosed with breast cancer. Risk of bias was assessed using the Newcastle Ottawa Scale (NOS). Data from single arm studies was pooled using meta-analysis of single proportions to provide overall point estimates and 95% confidence intervals for fixed and random effects models using the inverse variance and Der Simonian-Laird methods respectively. Heterogeneity was evaluated using the I2 statistic and sensitivity analysis and meta-regression were conducted. Results Five papers were included, when all studies were combined (n = 4,100) the mean utility (95% confidence interval) for random effects model was 0.83 (0.78, 0.89); for TNM 0-1 0.85 (0.75, 0.95); for TNM II 0.85 (0.78, 0.93); for TNM III 0.83 (0.77, 0.90) and for TNM IV 0.73 (0.63, 0.82).The utility of patients in State P (first year after primary breast cancer) 0.84 (0.80, 0.88); in State R (first year after recurrence) 0.73 (0.69, 0.76), in State S (second and following years after primary breast cancer or recurrence) 0.88 (0.83, 0.92); and in State M (metastatic disease) 0.78 (0.74, 0.82). Mean utility for duration since diagnosis 13 to 36 months was 0.88 (0.80, 0.96, I2 =95%); for 37 to 60 months 0.89 (0.82, 0.96, I2 =90%); for more than 60 months 0.86 (0.76, 0.96, I2 =90%). Mean utility for chemotherapy was 0.86 (0.79, 0.92, I2 =97%); for radiotherapy 0.83 (0.69, 0.96, I2 =97%); surgery 0.80 (0.69, 0.91, I2 =98%); concurrent chemo-radiation 0.70 (0.60, 0.81, I2 =86%) and endocrine therapy 0.90 (0.83, 0.97, I2 =91%). Conclusion: This study synthesises the evidence for health state utility values for Chinese women with breast cancer which is useful to inform cost utility models.

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“…However, in Cheng et al, and's (2016) study, the patients' bodies and minds gradually recovered after initial treatment. The study has shown that breast cancer chemotherapy patients with higher symptom burden often had poorer quality of life (Ou et al, 2019). The quality of life is positively correlated with the survival time of cancer survivors (Hoerger et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Hope and symptom burden of women with breast cancer undergoing chemotherapy: A cross‐sectional study

Zhou

et al. 2021

Journal of Clinical Nursing

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Aim This research aimed to explore the level of hope and symptom burden of breast cancer women undergoing chemotherapy, and predictive factors of hope were also investigated. Background Chemotherapy brings physical and psychological stress to breast cancer patients. As an effective coping strategy, hope gives them the courage to overcome difficulties and improve prognosis and survival. Therefore, efforts are needed to raise hope. Design/Methods A total of 450 women who were undergoing breast cancer chemotherapy participated in this cross‐sectional study. Sociodemographic data, disease characteristics, and measures of hope and symptom burden were collected using questionnaires. Hope was assessed using the validated Herth Hope Index, and the previously validated Memorial Symptom Assessment Scale was used to assess symptom burden. This paper adhered to the STROBE guidelines. Results Chinese breast cancer chemotherapy women hope average scores of 30.15 ± 4.82 were in the medium range of the Hearth Hope Index as specified by Herth to be 24–35. Patients with age ≤45, religious beliefs and lighter symptom burden have a higher level of hope. These variables explained a total of 22.9% of the variation in hope. Conclusions The level of hope for women undergoing breast cancer chemotherapy still needs to be further improved. Symptom burden can negatively predict hope. Relevance to clinical practice If nurses can decrease breast cancer chemotherapy women symptom burden, there is an impact on increasing levels of hope.

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Health‐related quality of life associated with different cancer treatments in Chinese breast cancer survivors in Taiwan

Cited by 15 publications

References 45 publications

Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Meta-analysis of health state utility values measured by EuroQol 5-dimensions (EQ5D) questionnaire in Chinese women with breast cancer

Hope and symptom burden of women with breast cancer undergoing chemotherapy: A cross‐sectional study

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