Health‐related quality of life in post‐infectious bronchiolitis obliterans: agreement between children and their proxy

Sarria, Edgar E.; Mundstock, Eduardo; Mocelin, Helena Teresinha; Fischer, Gilberto Bueno; Torres, Renato Rangel; Garbin, João Guilherme Meinem; Leal, Lisiane Freitas; Arend, Marcia Helena Rodrigues de Freitas; Stein, R.; Booij, Linda; Araújo, Rafael Moreno Ferro de; Mattiello, Rita

doi:10.1016/j.jpedp.2018.05.015

Cited by 1 publication

(2 citation statements)

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“…They found lower scores in patients with PIBO; however, they did not investigate any associations that may have an impact on HRQOL scores. In a more recent study, Sarria et al 11 examined the proxy versions of the same tools, and they showed that caregivers of patients with PIBO have a perception that their children's quality of life is lower than patients' themselves.…”

Section: Discussionmentioning

confidence: 99%

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Health‐related quality of life in patients with bronchiolitis obliterans

Atağ

İkizoğlu

Ergenekon

et al. 2020

Pediatric Pulmonology

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Introduction Bronchiolitis obliterans (BO) is mainly caused by infections and hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the health‐related quality of life (HRQOL) of children with BO compared to the healthy children and also to assess the HRQOL according to the etiology. Methods Postinfectious (group 1) and post‐HSCT BO (group 2) patients and healthy children were included in the study. HRQOL was assessed by the Short Form‐36 (SF‐36) and St George's Respiratory Questionnaire (SGRQ). Correlations between demographic and clinical characteristics, pulmonary function tests, high‐resolution chest tomography scores, and HRQOL were assessed. Results Thirty‐seven postinfectious and post‐HSCT BO patients and 34 healthy children were included in the study. Mean age was 13.8 ± 0.7 years. Mean forced vital capacity and forced expiratory volume1 were 60.7 ± 2.7% predicted, and 49.8 ± 3.1% predicted, respectively. The SF‐36 scores were lower in BO patients compared to healthy children (P < .01). Patients with better lung functions had higher SF‐36 scores, but lower SGRQ. The number of inhaled therapies, acute exacerbations, hospitalizations were inversely correlated with SF‐36. A positive correlation was found between these parameters and total SGRQ scores (r = .507, P = .02; r = .409, P = .12; r = .326, P = .049, respectively). SF‐36 scores were better in group 1 for subscales of physical role functioning and social role functioning compared to group 2. (P = .01, P = .01, respectively). Conclusion The HRQOL of patients with BO measured by SF‐36 was low compared to healthy children. SF‐36 scores were more affected in post‐HSCT BO patients. HRQOL of children with chronic lung disease should be taken into consideration in the management of these patients.

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Section: Discussionmentioning

confidence: 99%

“…There are limited studies evaluating the quality of life in children with BO. Sarria et al 10,11 showed that the general quality of life decreased in patients with PIBO and their caregivers. However, this study did not evaluate the quality of life related to respiratory health and the associated factors.…”

Section: Introductionmentioning

confidence: 99%