Health‐related quality of life of patients with colorectal neoplasms in China: A multicenter cross‐sectional survey

Abstract

Background and Aim This study aimed to clarify health‐related quality of life (HRQoL) of patients with colorectal precancer and colorectal cancer (CRC) in China and to better understand related utility scores. Methods A hospital‐based cross‐sectional survey was conducted in precancer and CRC patients from 2012 to 2014, covering 12 provinces in China. HRQoL was assessed with EuroQol 5‐Dimensions 3‐Levels. Utility scores were derived using Chinese value set. A multivariate regression model was established to explore potential predictors of utility scores. Results A total of 376 precancer (mean age 58.7 years, 61.2% men) and 2470 CRC patients (mean age 58.6 years, 57.6% men) were included. In five dimensions, there was a certain percentage of problem reported among precancer (range: 12.0% to 36.7%) and CRC (range: 32.4% to 50.3%) patients, with pain/discomfort being the most serious dimension. Utility scores of precancer and CRC patients were 0.870 (95% confidence interval [CI], 0.855–0.886) and 0.751 (95% CI, 0.742–0.759), both of which were lower than those of general Chinese population (0.960 [95% CI, 0.960–0.960]). Utilities for patients at stage I to stage IV were 0.742 (95% CI, 0.715–0.769), 0.722 (95% CI, 0.705–0.740), 0.756 (95% CI, 0.741–0.772), and 0.745 (95% CI, 0.742–0.767), respectively. Multivariate analysis showed that therapeutic regimen, time point of the interview, education, occupation, annual household income, and geographic region were associated with utilities of CRC patients. Conclusion Health‐related quality of life of both precancer and CRC patients in China declined considerably. Utility scores differed by sociodemographic and clinical characteristics, and findings of these utilities may facilitate implementation of further cost–utility evaluations.

Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey

“…Our study directly revealed that HRQOL of advanced CRC patients in China was markedly lower than that of the general population (17), but was higher in advanced CRC patients who were male, received less education, unemployed or laid-off, and from southwestern. Comparing males and feminine HRQOL scores, the HRQOL score was higher in males than in females, similar to the findings of the literature reports (18,19).…”

Health‐related quality of life among patients with esophageal, gastric, and colorectal cancer at Kenyatta National Hospital

“…From diagnosis to treatment, cancer survivors face mental, physical, and economic challenges and confusion regarding their social roles 4 . Numerous studies have demonstrated that cancer treatment adversely affects the HRQoL of patients 5–11 . In developing countries, HRQoL is generally low among cancer patients 12,13 .…”

“… 4 Numerous studies have demonstrated that cancer treatment adversely affects the HRQoL of patients. 5 , 6 , 7 , 8 , 9 , 10 , 11 In developing countries, HRQoL is generally low among cancer patients. 12 , 13 A recent systematic review showed that most cancer patients had a suboptimal overall HRQoL in Sub‐Saharan Africa.…”