Health risk assessment of environmental exposure to trichloroethylene

Brown, L.P.; Farrar, David G.; Rooij, C.G. de

doi:10.1016/0273-2300(90)90005-v

Cited by 17 publications

(13 citation statements)

References 40 publications

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“…As early as 1962 _ (Takamatsu, 1962), hepatotoxicity following TCE exposure was being assessed in humans. Since that time, TCE has been found to cause liver damage (Litt and Cohen, 1969;Baerg and Kimberg, 1970;Clearfield, 1970;Sax, 1975;Commission of the European Communities, 1976Allemand et al, 1978;Fielder et al, 1982;Nethercott et al, 1982;Pozzi et al, 1985;Brown et al, 1990;Flanagan et al, 1990;Wang and Stacey, 1990; Davidson and Beliles, 1991;Bai and Stacey, 1993). It should be noted, however, that hepatotoxicity is generally believed to be reversible upon the cessation of exposure (Davidson and Beliles, 1991).…”

Section: Cardiovascular Effectsmentioning

confidence: 93%

“…Kidney enlargement seems to be less pronounced and occurs less consistently than liver enlargement. Enlargement was associated with altered biochemical indices of renal function, but not abnormal histology in some of the intermediate-duration animal studies (Kjellstrand et al, 1983a,b;Nomiyama et al, 1986;Brown et al, 1990;ATSDR, 1993). ' Chronic experiments also revealed toxicity.…”

Section: Cardiovascular Effectsmentioning

confidence: 96%

“…In other studies, rodents have been shown to develop hepatic toxicity following exposure to TCE under a variety of conditions (Buben and O'Flaherty, 1985;Green and Prout, 1985;Rouisse and Chakrabarti, 1986;Candura and Faustman, 1991). An increase in liver weight and associated histopathological and biological changes have been reported in rats and mice exposed to TCE at relatively low concentrations for periods of up to 14 weeks (Kimmerle and Eben, 1973;Kjellstrand et al, 1983a,b;Brown et al, 1990). Hepatocellular injury, including hypertrophy and hyperplasia, have also been observed in both rats and mice (Stott et al, 1982;Elcombe, 1985).…”

mentioning

confidence: 89%

“…The CNS is also impacted by TCE exposure in animals (Baker, 1958;Bartonicek and Brun, 1970;Fielder et al, 1982;Brown et al, 1990) even at levels as low as 200 to 400 ppm (Grandjean, 1966). CNS toxicity in animals is characterized by ataxia, lethargy, hindlimb paralysis, and convulsions; irreversible CNS lesions with accompanying behavioral changes have been induced in several species by chronic exposure to TCE (Kjellstrand, 1980(Kjellstrand, , 1981a.…”

mentioning

confidence: 96%

“…The apparent threshold for central nervous system (CNS) effects is in the range of 81 to 300 ppm (Fielder et al, 1982;Brown et al, 1990). Exact dose-response relationships in humans are not known (Antti-Poika, 1982), although it is believed that the intensity of the exposure determines the degree of damage.…”

mentioning

confidence: 98%

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Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Gist

Burg

1995

Toxicol Ind Health

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This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons with documented exposure to TCE through drinking and use of contaminated water. The health effects reported in excess by some or all of the sex and age groups studied were speech and hearing impairments, effects of stroke, liver problems, anemia and other blood disorders, diabetes, kidney disease, urinary tract disorders, and skin rashes.

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Section: Cardiovascular Effectsmentioning

confidence: 93%

Section: Cardiovascular Effectsmentioning

confidence: 96%

mentioning

confidence: 89%

mentioning

confidence: 96%

mentioning

confidence: 98%

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Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Gist

Burg

1995

Toxicol Ind Health

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Chloroethylenes

Snedecor¹,

Hickman²,

Mertens³

2004

Kirk-Othmer Encyclopedia of Chemical Technology

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The physical and chemical properties, manufacturing methods, uses, environmental concerns, and toxicity of 1,2‐dichloroethane are discussed. 1,2‐Dichloroethylene, also known as acetylene dichloride, dio‐form, α,β ‐dichloroethylene, and sym ‐dichloroethylene, exists in two isomers cis[156‐59‐2] and trans[156‐59‐2]. This solvent is used as an extraction solvent and as a chemical intermediate for other chlorinated solvents and compounds. The article describes the manufacturing, chemical and physical properties, storage and handling, toxicity, and its common uses. Trichloroethylene, commonly referred to as “tri”, is a widely used vapor‐degreasing solvent. In recent years its popularity has fallen mostly because of environmental restrictions on its use. Trichloroethylene has excellent solvency properties for a large number of natural and synthetic substances. This article includes physical and chemical properties, production, and use information. In addition, safety, toxicological, and environmental regulations pertinent to trichloroethylene are reviewed. Tetrachloroethylene [127‐18‐4], perchloroethylene, tetrachloroethene, commonly referred to as “perc,” is widely used in the dry‐cleaning industry as well as metal cleaning and vapor degreasing because of its excellent solvent properties. It has no flash point or flammable limits in air or oxygen. This article includes the physical and chemical properties of tetrachloroethylene, historical production within the United States, manufacturing locations and processes, as well as typical quality specifications. In addition, safety and toxicological considerations and environmental regulations pertinent to tetrachloroethylene are reviewed. The Montreal Protocol has had an impact on all of the compounds discussed in this article.

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Trichloroethylene

Mertens

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Trichloroethylene, commonly referred to as “tri”, is a widely used vapor‐degreasing solvent. In recent years its popularity has fallen in favor of 1,1,1‐trichloroethane, mostly because of environmental restrictions on its use. Trichloroethylene has excellent solvency properties for a large number of natural and synthetic substances. This article includes physical and chemical properties, production, and use information. In addition, safety, toxicological, and environmental regulations pertinent to trichloroethylene are reviewed.

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Health risk assessment of environmental exposure to trichloroethylene

Cited by 17 publications

References 40 publications

Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Chloroethylenes

Trichloroethylene

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