Health risk assessment of exposure to chlorpyrifos and dichlorvos in children at childcare facilities

Kim, Ho-Hyun; Lim, Young-Wook; Yang, Ji-Yeon; Shin, Dong Chun; Ham, Hyun-Sook; Choi, Bum Chae; Lee, Jae-Young

doi:10.1016/j.scitotenv.2012.11.102

Cited by 42 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, lung cancer risk in the general population following exposure to zinc cadmium sulfide was estimated from Army testing according to this approach (National Research Council Subcommittee on Zinc Cadmium 1997). Cancer potency was considered to characterize cancer risk after exposure to pesticides like chlorpyrifos and dichlorvos (Kim et al 2013) or to food contaminants (Vogt et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

et al. 2020

View full text Add to dashboard Cite

Health risk associated with the use of combustible cigarettes is well characterized and numerous epidemiological studies have been published for many years. Since more than a decade, innovative non-combusted tobacco products have emerged like heated tobacco products (HTP) or electronic cigarettes (EC). Long-term effects of these new products on health remain, however, unknown and there is a need to characterize associated potential health risks. The time dedicated to epidemiological data generation (at least 20 to 40 years for cancer endpoint), though, is not compatible with innovative development. Surrogates need, therefore, to be developed. In this work, non-cancer and cancer risks were estimated in a range of HTP and commercial combustible cigarettes based upon their harmful and potentially harmful constituent yields in aerosols and smoke, respectively. It appears that mean lifetime cancer risk values were decreased by more than one order of magnitude when comparing HTPs and commercial cigarettes, and significantly higher margin of exposure for non-cancer risk was observed for HTPs when compared to commercial cigarettes. The same approach was applied to two commercial ECs. Similar results were also found for this category of products. Despite uncertainties related to the factors used for the calculations and methodological limitations, this approach is valuable to estimate health risks associated to the use of innovative products. Moreover, it acts as predictive tool in absence of long-term epidemiological data. Furthermore, both cancer and non-cancer risks estimated for HTPs and ECs highlight the potential of reduced risk for non-combusted products when compared to cigarette smoking.

show abstract

Section: Introductionmentioning

confidence: 99%

Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is known that households with children commonly use and store pesticide products. [1][2][3] The use of pesticides at child care facilities, 4 on athletic fields, 5 and on school grounds 6 could all present potential exposures and health hazards to children. Because children's immune systems are still developing, they may provide less protection than adult immune systems.…”

mentioning

confidence: 99%

Residential Exposure to Pesticide During Childhood and Childhood Cancers: A Meta-Analysis

et al. 2015

View full text Add to dashboard Cite

CONTEXT: There is an increasing concern about chronic low-level pesticide exposure during childhood and its influence on childhood cancers. OBJECTIVE:In this meta-analysis, we aimed to examine associations between residential childhood pesticide exposures and childhood cancers. DATA SOURCES:We searched all observational studies published in PubMed before February 2014 and reviewed reference sections of articles derived from searches.STUDY SELECTION: The literature search yielded 277 studies that met inclusion criteria.DATA EXTRACTION: Sixteen studies were included in the meta-analysis. We calculated effect sizes and 95% confidence intervals (CIs) by using a random effect model with inverse variance weights. RESULTS:We found that childhood exposure to indoor but not outdoor residential insecticides was associated with a significant increase in risk of childhood leukemia (odds ratio [OR] = 1.47; 95% CI, 1.26-1.72; I 2 = 30%) and childhood lymphomas (OR = 1.43; 95% CI, 1.15-1.78; I 2 = 0%). A significant increase in risk of leukemia was also associated with herbicide exposure (OR = 1.26; 95% CI, 1.10-1.44; I 2 = 0%). Also observed was a positive but not statistically significant association between childhood home pesticide or herbicide exposure and childhood brain tumors. LIMITATIONS:The small number of studies included in the analysis represents a major limitation of the current analysis. CONCLUSIONS:Results from this meta-analysis indicated that children exposed to indoor insecticides would have a higher risk of childhood hematopoietic cancers. Additional research is needed to confirm the association between residential indoor pesticide exposures and childhood cancers. Meanwhile, preventive measures should be considered to reduce children's exposure to pesticides at home.

show abstract

“…Therefore, there was an increase in the use of phytosanitary products (mainly herbicides, insecticides, and fungicides) to improve crop production yield. However, the excessive application of pesticides has become an important environmental issue due to the high environmental concentrations found and the deleterious effects on non-target individuals [1,2,3,4]. Organophosphate pesticides are used in both agriculture and animal production being dichlorvos (2,2-dichlorovinyl dimethyl phosphate, DDVP) one of the most employed of this family.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it is used to treat a variety of parasitic worm infections in livestock, dogs, and humans [1]. Exposure to DDVP in living organisms can lead to several affections related to neurological, reproductive, immunological, hepatic, renal, respiratory, and metabolic systems [3,5]. In cultivated regions, soils and streams play an important role in the transport and fate of pesticides used in crops and farms.…”

Section: Introductionmentioning

confidence: 99%

Movement of Dichlorvos in Farm Soils: Batch and Column Studies.

Bustos

Grassi

Cirelli

et al. 2020

Preprint

View full text Add to dashboard Cite

Soils are the principal environmental fate of pesticides in agricultural areas. Thus, the kinetics, extension, and strength of the adsorption process become critical. Dichlorvos (DDVP) is an organophosphorous pesticide that is used both in agriculture and livestock production. Sorption/desorption assays of DDVP in two agricultural soils (with different textural characteristics) from Pampa Plain (Argentina) were performed in both batch and column systems. From batch studies, kinetics and sorption/desorption equilibrium parameters were estimated. Our results showed that the maxima adsorption is reached after 30 h of time of contact and followed a pseudo-first-order rate. Adsorption/desorption data were well fitted to the Freundlich model obtaining high adsorption constants of 90 mg(1-1/n) mL(1/n) g-1 and 21 mg(1-1/n) mL(1/n) g-1 for the clay loam and sandy loam soil, respectively. The isotherms were non-linear in both cases and the desorption process was unfavourable. Also, positive hysteresis was present for the sandy loam soil. From column studies, breakthrough curves were used to evaluate the mobility of DDVP in the soils at 1, 10, and 50 mg L-1 of DDVP. Eluted profiles were asymmetrical as well they presented retardation effects that were in connection with the results in batch conditions. Non-equilibrium sorption was stated for the DDVP movement through columns. Thus, high mobility was observed for DDVP in both soils despite their textural differences.

show abstract

Health risk assessment of exposure to chlorpyrifos and dichlorvos in children at childcare facilities

Cited by 42 publications

References 26 publications

Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

Residential Exposure to Pesticide During Childhood and Childhood Cancers: A Meta-Analysis

Movement of Dichlorvos in Farm Soils: Batch and Column Studies.

Contact Info

Product

Resources

About