Health risks of exposure to soil-borne dichlorodiphenyltrichloroethanes (DDTs): A preliminary probabilistic assessment and spatial visualization

Wang, Ruiqi; Qu, Chengkai; Li, Min; Shi, Changhe; Zhang, Jiaquan; Qi, Shihua

doi:10.1016/j.scitotenv.2021.144949

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…As a member of a group of banned persistent organic pollutants, the long history of the application of DDT has led to contamination worldwide . The order of activities was 4,4′-DDT > 4,4′-DDE > 4,4′-DDD ≈ 2,4′-DDT ≈ 2,4′-DDD (Figure c and Table S7), suggesting that the position of the chlorine atom may be one of critical factors affecting the transcription of ACE2 (Figure S3b).…”

Section: Resultsmentioning

confidence: 99%

Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection

Jin

Zhang

et al. 2022

Environ. Sci. Technol.

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Virus receptors are highly involved in mediating the entrance of infectious viruses into host cells. Here, we found that typical chemical exposure caused the upregulation of virus receptor mRNA levels. Chemicals with the same structural characteristics can affect the transcription of angiotensin-converting enzyme 2 ( ACE2 ), a dominant receptor of SARS-CoV-2. Some chemicals can also regulate the transcription of ACE2 by similar regulatory mechanisms, such as multilayer biological responses and the crucial role of TATA-box binding protein associated factor 6. The abovementioned finding suggested that chemical mixtures may have a joint effect on the ACE2 mRNA level in the real scenario, where humans are exposed to numerous chemicals simultaneously in daily life. Chemically regulated virus receptor transcription was in a tissue-dependent manner, with the highest sensitivity in pulmonary epithelial cells. Therefore, in addition to genetic factors, exogenous chemical exposure can be an emerging nongenetic factor that stimulates the transcription of virus receptor abundance and may elevate the protein expression. These alterations could ultimately give rise to the susceptibility to virus infection and disease severity. This finding highlights new requirements for sufficient epidemiological data about exposomes on pathogen receptors in the host.

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Section: Resultsmentioning

confidence: 99%

Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection

Jin

Zhang

et al. 2022

Environ. Sci. Technol.

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“…By forming the multi-criteria spatial mapping in the assessment system, the visualization of risks can create a strait security risk map to further explore the spatial distribution of risks in the strait and support to understand the spatial correlation between risks and various indicators (Poggio and Vrscaj 2009 ; Wang et al 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Security risk assessment and visualization study of key nodes of sea lanes: case studies on the Tsugaru Strait and the Makassar Strait

et al. 2022

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Contamination, spatial distribution, and source contribution of persistent organic pollutants in the soil of Guiyang city, China: a case study

Zhang

Lan

Yang

et al. 2021

Environ Geochem Health

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Health risks of exposure to soil-borne dichlorodiphenyltrichloroethanes (DDTs): A preliminary probabilistic assessment and spatial visualization

Cited by 9 publications

References 37 publications

Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection

Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection

Security risk assessment and visualization study of key nodes of sea lanes: case studies on the Tsugaru Strait and the Makassar Strait

Contamination, spatial distribution, and source contribution of persistent organic pollutants in the soil of Guiyang city, China: a case study

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