Health-seeking behaviour of human brucellosis cases in rural Tanzania

Kunda, J.; Fitzpatrick, Julie; Kazwala, R. R.; French, Nigel P.; Shirima, Gabriel; MacMillan, Alastair; Kambarage, D. M.; Bronsvoort, Barend M. deC.; Cleaveland, Sarah

doi:10.1186/1471-2458-7-315

Cited by 89 publications

(93 citation statements)

References 19 publications

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“…This was reflected in the much longer duration of illness of brucellosis compared to malaria. Clearly, early diagnosis of brucellosis is required (Muriuki, 1994;Kunda et al, 2007). Muriuki et al's (1997) study in Narok, classified 0.8% (n= 1,037,875) of all 'flu-like' syndromes in humans as brucellosis, and 21.2% of these tested positive for Brucellosis on RBT.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of brucellosis in livestock and incidences in humans in east Africa

Chota¹,

Magwisha²,

Stella³

et al. 2016

Afr. Crop Sci. J.

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Section: Discussionmentioning

confidence: 99%

Prevalence of brucellosis in livestock and incidences in humans in east Africa

Chota¹,

Magwisha²,

Stella³

et al. 2016

Afr. Crop Sci. J.

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“…Others have shown extended delays in health-seeking behaviors among individuals with brucellosis in sub-Saharan Africa. 6 A large proportion of individuals with probable brucellosis also had several clinical signs classically ascribed to brucellosis, including hepato-or splenomegaly, lymphadenopathy, and radiographic evidence of pleural effusions. The one participant with probable brucellosis who did not survive to hospital discharge died with complications of a chronic pulmonary infection other than tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

“…2,5 These non-specific clinical features, in addition to low clinical suspicion and inadequate diagnostic capacity, result in brucellosis often being underdiagnosed and untreated in lowresource countries. 3,6,7 Although several species of Brucella can cause human infection, B. melitensis and B. abortus are the most frequently implicated species. 8,9 B. melitensis, the more common and virulent cause of human disease, 2,10 is typically associated with sheep and goats, and B. abortus with cattle, although cross-species infections can occur.…”

Section: Introductionmentioning

confidence: 99%

Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Bouley

Biggs²,

Stoddard³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a 4-fold increase in microagglutination test titer, and probable brucellosis was defined as a single reciprocal titer 160. Among 870 participants enrolled in the study, 455 (52.3%) had paired sera available. Of these, 16 (3.5%) met criteria for confirmed brucellosis. Of 830 participants with 1 serum sample, 4 (0.5%) met criteria for probable brucellosis. Brucellosis was associated with increased median age (P = 0.024), leukopenia (odds ratio [OR] 7.8, P = 0.005), thrombocytopenia (OR 3.9, P = 0.018), and evidence of other zoonoses (OR 3.2, P = 0.026). Brucellosis was never diagnosed clinically, and although all participants with brucellosis received antibacterials or antimalarials in the hospital, no participant received standard brucellosis treatment. Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania.

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“…In some series, 16% of patients were diagnosed with a delay of more than three months after the onset of symptoms (41,47). The diagnostic delay could be a result of either misdiagnosis or postponed visit to a medical professional (8,53).…”

Section: Discussionmentioning

confidence: 99%

Human Brucellosis in Macedonia – 10 Years of Clinical Experience in Endemic Region

Bosilkovski¹,

Krteva²,

Dimzova³

et al. 2010

Croat Med J

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Aim To present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia.Methods A total of 550 patients with brucellosis treated between 1998 and 2007 were retrospectively assessed for their demographic, epidemiological, and clinical characteristics and outcomes.Results Of the 550 patients, 395 (72%) were male. The median age was 34.5 years (range, 1-82). Direct contact with infected animals was recorded in 333 (61%) patients and positive family history in 310 (56%). The most frequently seen symptoms were arthralgia (438, 80%), fever (419, 76%), and sweating (394, 72%). The most common signs were fever and hepatomegaly, which were verified in 357 (65%) and 273 (50%) patients, respectively. Focal brucellosis was found in 362 patients (66%) and osteoarticular in 299 (54%). Therapeutic failures were registered in 37 (6.7%) patients. Of the 453 (82%) patients who completed a follow-up period of at least 6 months, relapses occurred in 60 (13%). ConclusionDue to non-specific clinical manifestation and laboratory parameters, brucellosis should be considered one of the differential diagnoses of any patient suffering from obscure involvement of various organs in a brucellosis-endemic region. High percentage of relapses and therapeutic failures in spite of the use of currently recommended therapeutic regimens indicates the seriousness of this zoonosis and the need to control it.

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Health-seeking behaviour of human brucellosis cases in rural Tanzania

Cited by 89 publications

References 19 publications

Prevalence of brucellosis in livestock and incidences in humans in east Africa

Prevalence of brucellosis in livestock and incidences in humans in east Africa

Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Human Brucellosis in Macedonia – 10 Years of Clinical Experience in Endemic Region

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