Health state utilities of a population of Nigerian hypertensive patients

Ekwunife, Obinna Ikechukwu; Aguwa, C. N.; Adibe, Maxwell Ogochukwu; Barikpaoar, Ebenezer; Onwuka, Chioma J

doi:10.1186/1756-0500-4-528

Cited by 13 publications

(14 citation statements)

References 19 publications

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“…In a Swedish population with high BP, health-state utility was 0.73 when using a rating scale and 0.81 when using TTO [ 6 ]. In a Nigerian hypertensive population, it was relevantly lower at 0.35(+/-0.42), using the HUI3 method [ 23 ]. Again, these comparisons should be interpreted cautiously because different instruments and methods were applied [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Utilities of Patients with Hypertension in Northern Vietnam

Nguyen

Krabbe

Nguyen³

et al. 2015

PLoS ONE

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ObjectivesThe study aims to inform potential cost-effectiveness analysis of hypertension management in Vietnam by providing utilities and predictors of utilities in patients with hypertension.MethodsHypertensive patients up to 80 years old visiting the hospital were invited to participate in a survey using Quality Metric’s Short-form 36v2TM translated into Vietnamese. Health-state utilities were estimated by applying a previously published algorithm.ResultsThe mean utility of the 691 patients interviewed was 0.73. Controlling for age, sex, blood pressure (BP) stage, and history of stroke, the utilities in older patients were lower than those in younger ones, and statistically significantly different between the extremes of youngest and oldest groups (p = 0.03). Utility in males was higher than in females (p = 0.002). As expected, patients with a history of stroke appeared to exhibit lower utilities than patients without such history, but the difference was not statistically significant (p = 0.73). Patients with more than three comorbidities did have lower utilities than patients without comorbidity (p = 0.01).ConclusionsHealth-state utilities found among hypertensive patients in Vietnam were similar to those found in other international studies. It is suggested that lower of health-state utilities exist among those patients who were older, female or had more than three comorbidities in comparison with respective reference groups. However, further research for confirmation is required. The data from this study provide a potential reference on health-state utilities of hypertensive patients in Vietnam as an input for future cost-effectiveness analysis of interventions. Also, it may serve as a reference for other similar populations, especially in the context of similar environments in low income countries.

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Section: Discussionmentioning

confidence: 99%

Utilities of Patients with Hypertension in Northern Vietnam

Nguyen

Krabbe

Nguyen³

et al. 2015

PLoS ONE

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“…16 Stroke patients imposed the greatest HRQoL deficit among all other co-morbidities in both IG and CG. The HRQoL deficit associated with stroke and hypertension has been reported by Ekwunife et al 17 Antihypertensive drug induced Headache and antiplateletic drug induced gastritis, were the most adverse reactions observed in intervention group during the study period which showed a consistent pattern in study conducted by Gholami et al and Singhal Rohit et al 18 Patients with more than one diseases and with polypharmacy had poor quality of life which showed a similar result in study conducted by Divaldo pereira et al 19 about pharmaceutical care in elderly, in which there was a positive correlation between number of diseases and number of comorbidities with QOL.…”

Section: Discussionmentioning

confidence: 75%

Impact of intensified pharmaceutical care on health related quality of life in patients with stroke in a tertiary care hospital

Chandrasekhar

Pradeep

Geoji

et al. 2018

Clinical Epidemiology and Global Health

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Background: The study investigates the pharmaceutical care concept to optimize drug therapy, minimize drug related problems and thereby improving health related quality of life (HRQoL) of stroke patients. Since stroke is a major health problem that negatively affects the patient's quality of life, it is relevant to the current pharmaceutical care scenario in a developing country like India. HRQoL related to stroke and life satisfaction after stroke is the important healthcare measures. Methodology: Prospective interventional study conducted among inpatients of neurology department in a tertiary care referral hospital. 128 Patients with TIA/ischemic stroke were allocated to intervention group and control group (64 in each group). Pharmaceutical care was provided to the patients in the intervention group. SF-36 questionnaire was administered to both control group and interventional group to evaluate the patient's HRQoL. Adherence to entire therapy and antithrombotic therapy in both control group and intervention group were assessed using Morisky Medication Adherence Scales MMAS-8. Results: Prevalence of ischemic stroke was more compared to hemorrhagic stroke. During the study, the intervention group showed high adherence to overall therapy than the control group. With an intensified pharmaceutical care, improvement in the HRQoL was observed in intervention group and was manifested in subscales and summary measures of SF-36. Conclusion: The study enables demonstration and application of a pharmaceutical care program among stroke patients to prevent complications to improve HRQoL. This study indicates that pharmaceutical care can be performed in both hospital and community settings as it provides more benefit and positive impact on patient'HRQoL.

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“…The health related quality of life weights for the different states (non-symptomatic, stroke, and CHD) were obtained from the data of a health utility state assessment carried out in Nigeria [8]. To obtain the QALYs which represent the clinical outcome, the weights were multiplied by the number of life years spent in the different states, and then averaged over a life time of 30 years with a utility discount of 3%.…”

Section: Methodsmentioning

confidence: 99%

Cost-utility analysis of antihypertensive medications in Nigeria: a decision analysis

Ekwunife

Okafor

Ezenduka

et al. 2013

Cost Eff Resour Alloc

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BackgroundMany drugs are available for control of hypertension and its sequels in Nigeria but some are not affordable for majority of the populace. This serious pharmacoeconomic question has to be answered by the nation’s health economists. The objective of this study was to evaluate the cost-effectiveness of drugs from 4 classes of antihypertensive medications commonly used in Nigeria in management of hypertension without compelling indication to use a particular antihypertensive drug.MethodsThe study employed decision analytic modeling. Interventions were obtained from a meta-analysis. The Markov process model calculated clinical outcomes and costs during a life cycle of 30 years of 1000 hypertensive patients stratified by 3 cardiovascular risk groups, under the alternative intervention scenarios. Quality adjusted life year (QALY) was used to quantify clinical outcome. The average cost of treatment for the 1000 patient was tracked over the Markov cycle model of the alternative interventions and results were presented in 2010 US Dollars. Probabilistic cost-effectiveness analysis was performed using Monte Carlo simulation, and results presented as cost-effectiveness acceptability frontiers. Expected value of perfect information (EVPI) and expected value of parameter perfect information (EVPPI) analyses were also conducted for the hypothetical population.ResultsThiazide diuretic was the most cost-effective option across the 3 cardiovascular risk groups. Calcium channel blocker was the second best for Moderate risk and high risk with a willingness to pay of at least 2000$/QALY. The result was robust since it was insensitive to the parameters alteration.ConclusionsThe result of this study showed that thiazide diuretic followed by calcium channel blocker could be a feasible strategy in order to ensure that patients in Nigeria with hypertension are better controlled.

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Health state utilities of a population of Nigerian hypertensive patients

Cited by 13 publications

References 19 publications

Utilities of Patients with Hypertension in Northern Vietnam

Utilities of Patients with Hypertension in Northern Vietnam

Impact of intensified pharmaceutical care on health related quality of life in patients with stroke in a tertiary care hospital

Cost-utility analysis of antihypertensive medications in Nigeria: a decision analysis

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