Health status, quality of life and socioeconomic situation of people with spinal cord injuries six years after discharge from a hospital in Bangladesh

Hossain, Mohammad Sohrab; Islam,; Rahman, Md. Akhlasur; Glinsky, Joanne; Herbert, Robert D.; Ducharme, Stanley; Harvey, L A

doi:10.1038/s41393-019-0261-9

Cited by 24 publications

(15 citation statements)

References 42 publications

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“…After injury, the monthly median (IQR) income of each family member was US$0 (US$0-US $18) per family member. This was sufficient to keep 9% of Our data on participants' incomes prior to injury are broadly consistent with data from our previous study of a similar cohort discharged from CRP in 2011 [26]. We found in our previous study that participants who were wheelchair dependent at discharge earnt a median (IQR) of US$65 (US $39-US$104) per month prior to injury.…”

Section: Incomesupporting

confidence: 88%

“…A study from Nepal found that less than half of those with an SCI had any income many years after discharge from hospital [38]. Our previous study from Bangladesh showed that only 37% of people who were wheelchair dependent on discharge from hospital were employed 2 years after discharge [3] and only 42% were employed 6 years after discharge [26]. Some evidence suggests that those who do gain employment have much lower salaries than they had prior to injury [38].…”

Section: Incomementioning

confidence: 99%

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Loss of work-related income impoverishes people with SCI and their families in Bangladesh

et al. 2019

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Study design Cross-sectional study. Objectives To determine the degree of impoverishment of people with spinal cord injury (SCI) and their families in Bangladesh caused by loss of work-related income following injury. Setting Spinal cord injury centre, Bangladesh. Methods A total of 410 wheelchair-dependent people with recent SCI about to be discharged from a hospital in Bangladesh were interviewed to determine the size of their families, their incomes from paid work prior to injury and the incomes of their family members. These data were used to calculate income per family unit and per family member prior to and immediately after injury. Results Ninety percent of the participants were men, 98% were from rural areas of Bangladesh and 58% were manual labours prior to injury. Median (interquartile range, IQR) family size was 5 (4-6) people. Prior to injury, 74% of participants were the main income earners for their families and 50% provided the only source of income for their families. Participants' median (IQR) monthly income prior to injury was US$106

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Section: Incomesupporting

confidence: 88%

Section: Incomementioning

confidence: 99%

Loss of work-related income impoverishes people with SCI and their families in Bangladesh

et al. 2019

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“…The secondary injury is a complex series of response including local oedema, ischemia, focal haemorrhage, oxidative stress and inflammatory responses, which occurs on the basis of the primary injury. Due to the non-regeneration of the neurons, patients often suffer from sensory disturbance as well as loss of sensation, sphincter or muscle function, which significantly declines the quality of life of patients [3]. Therefore, preventing spinal cord against traumatic or nontraumatic injury may be a hopeful method for reducing the morbidity of SCI.…”

Section: Introductionmentioning

confidence: 99%

Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Geniposide is an active ingredient with anti-apoptotic and anti-inflammatory properties. This study was to examine the effects of geniposide on a cell model of spinal cord injury (SCI). PC12 cells were administrated with geniposide before subjected to LPS. The effects of geniposide were analyzed by utilizing CCK-8 assay, apoptosis assay, ELISA, RT-qPCR and Western blot. We found that PC12 cells viability was unchanged by treating with geniposide. However, geniposide with concentrations of 200 or 300 lg/mL significantly mitigated LPS-evoked viability loss. Meanwhile, apoptosis driven by LPS was mitigated by geniposide, which accompanied with p53, Bax and cleaved caspase-3 down-regulation, and Bcl-2 up-regulation. Besides this, the expression and release of IL-1b, IL-6, IL-8 and TNF-a evoked by LPS were mitigated by geniposide. miR-145-5p was a target of geniposide. miR-145-5p expression was up-regulated by geniposide, and geniposide did not protect PC12 cells against LPS injury when miR-145-5p was silenced. Moreover, geniposide inhibited NF-jB and JNK pathways via up-regulating miR-145-5p. In short, the present work described the neuroprotective effects of geniposide by targeting miR-145-5p. Further mechanisms involved in geniposide's beneficial effects are correlated with the inhibited NF-jB and JNK pathways. HIGHLIGHTS 1. Geniposide prevents LPS-induced injury in PC12 cells; 2. Geniposide up-regulates miR-145-5p; 3. Geniposide protects PC12 cells via up-regulation of miR-145-5p; 4. Geniposide inhibits NF-jB and JNK pathways via up-regulation of miR-145-5p.

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“…In LMICs such as Bangladesh, those with SCI and their families often live in extreme poverty. We found that 65% of patients admitted to CRP in 2011 were living below the poverty line when followed up 6 years later [ 28 ], and that 91% of the families of participants in the CIVIC trial were thrown into extreme poverty by the loss of the person’s income [ 19 ]. This highlights the pressing need of these people and their families for financial assistance after injury, as was also noted in the 2013 World Health Organisation Report on SCI [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Understanding how a community-based intervention for people with spinal cord injury in Bangladesh was delivered as part of a randomised controlled trial: a process evaluation

et al. 2020

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Design Mixed methods study Setting Community, Bangladesh Objectives To understand how a community-based intervention for people with spinal cord injury (SCI) in Bangladesh was delivered as part of a randomised controlled trial and to gauge the perceptions of participants and healthcare professionals to the intervention. Methods A community-based intervention was administered to 204 participants as part of a large randomised controlled trial (called the CIVIC trial). Case-managers followed-up participants with regular telephone calls and home visits over the first 2 years after discharge. The following data were collected alongside the trial: (i) chart audit of telephone calls and home visits (ii) recordings of 20 telephone calls (iii) interviews with 14 Intervention participants and four healthcare professionals including three case-managers. Results Participants received the target number of telephone calls and home visits. Pressure injuries were identified as a problem during at least one telephone call by 43% of participants. Participants and case-managers valued regular telephone calls and home visits, and believed that calls and visits prevented complications and alleviated social isolation. Participants trusted case-managers and were confident in the care and advice provided. Case-managers expressed concerns that people with SCI in Bangladesh face many problems impacting on well-being and motivation stemming from poverty, limited employment opportunities, societal attitudes and inaccessible environments. Conclusion A community-based intervention involving regular telephone calls and home visits was administered as intended and was well received by the recipients of the care. Nonetheless, people with SCI in Bangladesh face economic and social problems which cannot be fully addressed by this type of intervention alone.

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Health status, quality of life and socioeconomic situation of people with spinal cord injuries six years after discharge from a hospital in Bangladesh

Cited by 24 publications

References 42 publications

Loss of work-related income impoverishes people with SCI and their families in Bangladesh

Loss of work-related income impoverishes people with SCI and their families in Bangladesh

Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p

Understanding how a community-based intervention for people with spinal cord injury in Bangladesh was delivered as part of a randomised controlled trial: a process evaluation

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