Health supplements for allergic rhinitis: A mixed-methods systematic review

Pellow, Janice; Nolte, Anna; Temane, Annie; Solomon, Elizabeth M.

doi:10.1016/j.ctim.2020.102425

Cited by 8 publications

(4 citation statements)

References 76 publications

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“…Cao et al [ 21 ] reported that kaempferol is used as Parkinson disease protein 7 modulator for preventing mast cell-mediated allergic disorders through attenuating Lyn activation. While promising evidence has been found for single food factors, there have been reports that combination of food factors is also beneficial, including mixtures of vitamin D3, quercetin, and Perilla frutescens , and mixtures of vitamin D3 and Lactobacillus reuteri [ 22 ]. Similarly, we had confirmed that simultaneous intake of Enterococcus faecalis IC-1 and luteolin suppressed allergy in OVA-induced allergic mice [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin

Mizuno

Fujioka

Bitani

et al. 2022

IJMS

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In recent years, the incidence of type I hypersensitivity including hay fever has been increasing year by year in Japan. Our previous study using mice showed that only oral, but not intraperitoneal, administration of fucoidan extracted from seaweed (Saccharina japonica) suppressed type I hypersensitivity by secretion of galectin-9, which has a high affinity for IgE in the blood. However, the amount of seaweed required to achieve this activity is quite high (12 g dry weight per person per day). Therefore, the purpose of this study was to search for food ingredients in vegetables that enhance type I hypersensitivity suppression effect when consumed together with fucoidan. As a result, the enhanced effect was observed in extracts from Welsh onions and onions among vegetables. When we compared the polyphenols in the vegetables that showed activity with those that did not, flavonols such as quercetin and kaempferol were found as candidates. When quercetin or kaempferol (100 μg each) were orally administered at the same time, even at amounts where fucoidan alone showed no anti-allergic activity, anti-allergic effects were observed. More interestingly, when both flavonols were combined and administered simultaneously at half the amount of each of the above flavonols (50 μg), while the fucoidan amount remained the same, a similar effect was observed as when each flavonol (100 μg) was administered alone. The simultaneous intake of fucoidan and vegetables containing high contents of quercetin or kaempferol may reduce fucoidan intake while maintaining the allergy suppression effect, suggesting the importance of food combination.

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Section: Discussionmentioning

confidence: 99%

Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin

Mizuno

Fujioka

Bitani

et al. 2022

IJMS

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“…Polyphenols extracted from apples, which consist primarily of procyanidins, tannins, catechins, and epicatechins, are also suspected to be effective in the treatment of allergic rhinitis as they have been reported to inhibit mast cell activation and histamine release [257]. Two randomized clinical studies confirmed that high-dose (at least 200 mg/day) consumption of apple polyphenols significantly attenuates nasal symptoms including sneezing, rhinorrhea, and swelling of the nasal turbinates in both patients with persistent allergic rhinitis allergic to house dust mites and those with seasonal symptoms due to cedar pollen allergy [250].…”

Section: Allergic Rhinitismentioning

confidence: 98%

“…Furthermore, evidence from in vivo studies has revealed that other flavonoids, such as luteolin, myricetin, naringenin, baicalin, rosmarinic acid, procyanidins, and catechin, were also able to reduce nasal itching and sneezing frequency, infiltration of inflammatory cells, nasal mucosa thickness and mucus secretion as well as decrease the levels of allergenspecific IgE in murine models of allergic rhinitis [165,169,[246][247][248][249][250][251][252]. These findings support the potential therapeutic application of flavonoids in the treatment of allergic rhinitis; however, the clinical studies are limited.…”

Section: Allergic Rhinitismentioning

confidence: 99%

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Dębińska,

Sozańska

2023

Nutrients

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In light of the constantly increasing prevalence of allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for the development and progression of these diseases. Nowadays, much attention has been paid to the development of dietary interventions using natural substances with anti-allergy activities. In this respect, dietary polyphenols have been studied extensively as one of the most prominent natural bioactive compounds with well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to discuss the mechanisms underlying the potential anti-allergic actions of polyphenols related to their ability to reduce protein allergenicity, regulate immune response, and gut microbiome modification; however, these issues need to be elucidated in detail. This paper reviews the current evidence from experimental and clinical studies confirming that various polyphenols such as quercetin, curcumin, resveratrol, catechins, and many others could attenuate allergic inflammation, alleviate the symptoms of food allergy, asthma, and allergic rhinitis, and prevent the development of allergic immune response. Conclusively, dietary polyphenols are endowed with great anti-allergic potential and therefore could be used either for preventive approaches or therapeutic interventions in relation to allergic diseases. Limitations in studying and widespread use of polyphenols as well as future research directions are also discussed.

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“…Antihistamine administrations can cause nasal irritation, bitter aftertaste, and headache. Adverse effects of conventional medications made AR patients seek alternative therapies, which have fewer side effects [13][14][15]. For this reason, an increasing interest in herbal medicines that contain several natural compounds and have minimal or no undesirable side effects for treating various diseases is reported worldwide [16,17].…”

Section: Introductionmentioning

confidence: 99%

Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology

et al. 2023

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Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and allergic rhinitis (AR) share pathophysiology and pharmacotherapeutic interventions, AEO inhalation can also ameliorate upper respiratory allergic diseases. This study explored the protective effects of AEO on AR with network pharmacological pathway prediction. The potential target pathways of AEO were analyzed by a network pharmacological approach. The BALB/c mice were sensitized by ovalbumin (OVA) and 10 μm particular matter (PM10) to induce allergic rhinitis. Aerosolized AEO 0.0003% and 0.03% were delivered by nebulizer for 5 min a day, 3 times a week for 7 weeks. Nasal symptoms (sneezing and rubbing), histopathological changes in nasal tissues, serum IgE, and zonula occludens-1 (ZO-1) expressions on nasal tissues were analyzed. After AR induction with OVA+PM10 and inhalation of AEO 0.0003% and 0.03% treatment, AEO significantly decreased allergic symptoms (sneezing and rubbing), hyperplasia of nasal epithelial thickness, goblet cell counts, and serum IgE level. The network analysis demonstrated that the possible molecular mechanism of AEO is highly associated with the IL-17 signaling pathway and tight junction. The target pathway of AEO was investigated in RPMI 2650 nasal epithelial cells. Treatment of AEO on PM10-treated nasal epithelial cells significantly reduced the production of inflammatory mediators related to the IL-17 signaling pathway, NF-κB, and the MAPK signaling pathway and prevented the reduction in TJ-related factors. When taken together, AEO inhalation may be considered as a potential treatment for AR by alleviating nasal inflammation and recovering the tight junction.

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Health supplements for allergic rhinitis: A mixed-methods systematic review

Cited by 8 publications

References 76 publications

Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin

Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology

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