Healthcare-associated infections and antimicrobial use in surgical wards of a large urban central hospital in Blantyre, Malawi: a point prevalence survey

Bunduki, Gabriel Kambale; Feasey, Nicholas; Henrion, Marc; Noah, Patrick; Musaya, Janelisa

doi:10.1016/j.infpip.2021.100163

Cited by 15 publications

(30 citation statements)

References 39 publications

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“…This systematic review and meta-analysis included a total of 43 studies conducted on 798 712 patients (ranging from 105 24 to 633 990 25 study participants). Among the included studies, 5 were conducted in China, 25 - 29 3 in Ethiopia, 30 - 32 3 in the USA, 33 - 35 2 in Switzerland, 36 , 37 2 in Benin, 38 , 39 2 in Germany, 40 , 41 2 in Italy, 42 , 43 2 in Iran, 44 , 45 and 2 in Poland.…”

Section: Resultsmentioning

confidence: 99%

“…One in each of France, 48 Turkey, 49 Cuba, 50 Thailand, 51 Albania, 52 Malawi, 24 Saudi Arabia, 53 Ghana, 54 Nigeria, 55 Argentina, 56 Rwanda, 57 Tanzania, 58 Georgia, 59 South Africa, 60 Tunisia, 61 Nepal, 62 Herzegovina, 63 Australia, 64 India, 65 and Cameroon. 66 Among the included studies, the highest incidence of SSI was reported in Tanzania, 58 which accounted for 26.0%.…”

Section: Resultsmentioning

confidence: 99%

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Global Incidence of Surgical Site Infection Among Patients: Systematic Review and Meta-Analysis

Mengistu

Alemu

Abdukadir

et al. 2023

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Healthcare-associated infections pose one of the most severe threats to patients’ health and remain a major challenge for healthcare providers globally. Among healthcare-associated infections, surgical site infection is one of the most commonly reported infections. It remains a major cause of morbidity and mortality across the world. The aim of this study was to provide a pooled incidence of surgical site infection among patients on a regional and global scale. This study was conducted under the PRISMA guidelines developed for systematic review and meta-analysis. The studies were searched using electronic databases (SCOPUS, PubMed/MEDLINE, Web of Science, Google Scholar, DOAJ, and MedNar) from June 1st, 2022 to August 4th, 2022, using Boolean logic operators (AND, OR, and NOT), Medical Subject Headings (MeSH), and keywords. The quality of the study was assessed using the Joanna Briggs Institute Critical Assessment tool to determine the relevance of each included article to the study. A comprehensive meta-analysis version 3 was used to estimate the pooled prevalence of surgical site infections among the patients. A total of 2124 articles were retrieved from the included electronic databases. Finally, after applying inclusion criteria, 43 articles conducted in 39 countries were included in the current study. The global pooled incidence of SSI was found to be 2.5% (95% CI: 1.6, 3.7). Based on the subgroup analysis by WHO region and survey period, the incidence of SSI was 2.7% (95% CI: 2.2, 3.3%) and 2.5% (95% CI: 1.8, 3.5%), respectively. The highest incidence was reported in the African Region (7.2% [95% CI: 4.3, 11.8%]) and among studies conducted between 1996 and 2001 (2.9% [95% CI: 0.9%, 8.8%]). This study revealed that the overall pooled incidence of SSI was 2.5%. SSI estimates varied among the WHO regions of the world. However, the highest incidence (2.7%) was observed in the African region. This indicates that there is a need to implement safety measures, including interventions for SSI prevention to reduce SSI and improve patient safety.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Global Incidence of Surgical Site Infection Among Patients: Systematic Review and Meta-Analysis

Mengistu

Alemu

Abdukadir

et al. 2023

INQUIRY

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“…Fifteen studies were included in the qualitative summary of the prevalence of HAIs among hospitalized patients in Africa. Overall, the prevalence of HAIs ranged between 7.24% and 28% [4,[19][20][21][22][23][24][25][26][27][28][29][30][31][32], and the prevalence varied between the regions in Africa. (2.0-10.8%) [22,26,28,30,31].…”

Section: Prevalence and Distribution Of Hais Among Hospitalized Patie...mentioning

confidence: 99%

Healthcare-associated infections in Africa: a systematic review and meta-analysis of point prevalence studies

Abubakar

Amir

Rodríguez‐Baño

2022

J of Pharm Policy and Pract

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Background There is limited data to describe the point-prevalence of healthcare-associated infections (HAIs) among patients at a regional level in Africa. This study estimated the pooled prevalence of HAIs and described the distribution of HAIs as well as the pathogens identified from African studies. Methods PubMed, Scopus and Google Scholar databases were searched to find point-prevalence studies of HAIs in Africa. Studies conducted in Humans that reported the prevalence of HAIs among hospitalized patients and published in English language from January 2010 to March 2022 were selected. Longitudinal studies of HAIs and unpublished studies were excluded. The reference list of the selected studies was checked to find additional studies. A meta-analysis was conducted using RevMan 5.4 and the pooled prevalence of HAIs was determined using a random effect model. Results Of the 6094 articles identified from the databases, fifteen eligible articles were selected. The studies were conducted in the North, South, East and West African regions with Tunisia (n = 4) and South Africa (n = 2) having the highest number of studies. Most of the studies (n = 12, 80.0%) had good quality. The pooled prevalence of HAIs was 12.76% (95% confidence interval [CI] 10.30–15.23) with a high degree of heterogeneity (I2 = 90.0%). The prevalence of HAIs varied between wards with the highest rate found in the ICU (25.2%–100%), followed by neonatal ICU/ward (7.0%–53.6%) and paediatric medical ward (2.7%–33.0%). Surgical site infection was the most common HAIs and accounted for 41.6% of all HAIs (95% CI 23.55–59.80), followed by bloodstream infection (17.07%, 95% CI 11.80–22.33) and respiratory tract infections/pneumonia (17.04%, 95% CI 13.21–20.87). Recent hospitalization (adjusted odds ratio [AOR]: 4.17, 95% CI 1.85–9.41), presence of peripheral vascular catheter (AOR: 2.87, 95% CI 1.54–5.36) and having diabetes mellitus (AOR: 2.46, 95% CI 1.45–4.17) were the strongest predictors of HAIs in Africa. Only 37.9% of HAIs had documented positive microbiological culture result with gram negative bacteria including Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Citrobacter been the most common microorganisms and accounted for 40%–100% of the pathogens. Conclusions The pooled point-prevalence of HAIs in Africa is more than two times higher than the rate reported in developed countries. The prevalence varied between the countries and was highest in the ICU and neonatal ICU/ward. Surgical site infection and bloodstream infection were the most common HAIs reported in African studies. Recent hospitalization, presence of peripheral vascular catheter and having diabetes mellitus were the strongest predictors of HAIs in African studies. Most of the HAIs are preventable with appropriate infection control measures and antimicrobial stewardship. Additional studies are needed especially in the Central African region. Future studies should be designed using standardized protocol and standardized definition to reduce heterogeneity among the studies.

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“…This systematic review and meta-analysis included a total of 38 studies conducted on 981,221 patients (ranging from 105 31 to 633 990 32 study participants). Among the included studies, 7 were conducted in China, 32 - 38 2 in each Switzerland, 39 , 40 USA, 41 , 42 Turkey, 43 , 44 Iran, 45 , 46 Italy, 47 , 48 and Poland.…”

Section: Resultsmentioning

confidence: 99%

“…Among the included studies, 7 were conducted in China, 32 - 38 2 in each Switzerland, 39 , 40 USA, 41 , 42 Turkey, 43 , 44 Iran, 45 , 46 Italy, 47 , 48 and Poland. 49 , 50 However, one articles were selected from each Benin, 51 France, 52 Cuba, 53 Thailand, 54 Albania, 55 Malawi, 31 Saudi Arabia, 56 Ghana, 57 Argentina, 58 Ethiopia, 59 Tunisia, 60 Belgium, 61 Nepal, 62 Kuwait, 63 Germany, 64 Australia, 65 Herzegovina, 66 India, 67 Cameroon 68 ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Incidence of Urinary Tract Infection Among Patients: Systematic Review and Meta-Analysis

Mengistu

Alemu

Abdukadir

et al. 2023

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Healthcare-associated infection is one of the most common and severe threats to patients’ health and remains a significant challenge for healthcare providers. Among healthcare-associated infections, urinary tract infection (UTI) is one of the most common infections. This study aimed to determine the global incidence of UTI among patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline was used to perform this systematic review and meta-analysis. The articles were searched from April 4 to August 5, 2022, from electronic databases (Scopus, PubMed, Web of Science, Google Scholar, DOAJ, and MedNar) using Boolean logic operators, MeSH terms, and keywords. The quality of the study was assessed using the JBI Critical Assessment tool. One thousand nine ninety three articles were retrieved from the electronic databases, of which 38 articles conducted on 981 221 patients were included in the current study. The study found the global pooled incidence of UTI accounted for 1.6%. Based on the subgroup analysis by survey period and WHO region, the highest incidence of UTI was reported in the African Region [3.6%] and among studies conducted between 1996 and 2001 [3.7%]. This study revealed the overall pooled incidence of UTI was 1.6%. The highest incidence of UTI (3.6%) was reported in the African region. This indicates that there is a need to implement safety measures.

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Healthcare-associated infections and antimicrobial use in surgical wards of a large urban central hospital in Blantyre, Malawi: a point prevalence survey

Cited by 15 publications

References 39 publications

Global Incidence of Surgical Site Infection Among Patients: Systematic Review and Meta-Analysis

Global Incidence of Surgical Site Infection Among Patients: Systematic Review and Meta-Analysis

Healthcare-associated infections in Africa: a systematic review and meta-analysis of point prevalence studies

Incidence of Urinary Tract Infection Among Patients: Systematic Review and Meta-Analysis

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