Healthcare professional surveys to investigate the implementation of the isotretinoin Pregnancy Prevention Programme: a descriptive study

Abstract

The observed non-adherence to the isotretinoin PPP calls for careful evaluation of risk minimisation plans and participation of all stakeholders in the development of these plans.

Community pharmacists’ knowledge and perceptions on risk management plans in the Southern Region of Portugal

“…However, references for non-adherence with the isotretinoin Pregnancy Prevention Program by pharmacists and dermatologists were found (2,13). Pharmacists were asked for proposals to increase compliance and suggested better communication and better information tools to improve the pharmacy monitoring systems (2). This evidence is in line with the results of our study.…”

“…Also, the clozapine restricted distribution program forms the basis for relaxing the restrictions and expanding the population that may benefit from the drug (21). Medical literature on the knowledge of professionals on these programs is scarce (2), and no studies were found on the community pharmacists' awareness of risk management plans. However, references for non-adherence with the isotretinoin Pregnancy Prevention Program by pharmacists and dermatologists were found (2,13).…”

“…Medical literature on the knowledge of professionals on these programs is scarce (2), and no studies were found on the community pharmacists' awareness of risk management plans. However, references for non-adherence with the isotretinoin Pregnancy Prevention Program by pharmacists and dermatologists were found (2,13). Pharmacists were asked for proposals to increase compliance and suggested better communication and better information tools to improve the pharmacy monitoring systems (2).…”

“…This tragic event alerted the safety profiles of drugs, since what was thought to be a relatively safe medicine concealed a severe health risk. This disaster was a pivotal point in the rise of pharmacovigilance societal awareness and scientific relevance (2).…”

Compliance with pregnancy prevention plan recommendations in 8672 French women of childbearing potential exposed to acitretin

“…The present study showed that pregnancy testing was performed even less often than in isotretinoin utilisation studies that assessed PT compliance. A recent Dutch survey showed that 65% of dermatologists always perform a pregnancy test before prescribing isotretinoin . A Canadian cross‐sectional study, designed to collect women's self‐reported information, concluded that physicians prescribed a PT before starting isotretinoin for 44% of women and prescribed a monthly PT for 13% of women .…”