Healthy eating recommendations: good for reducing dietary contribution to the body’s advanced glycation/lipoxidation end products pool?

Castillo, María Dolores del; Iriondo‐DeHond, Amaia; Iriondo-DeHond, Maite; González, Ileana; Medrano-Fernández, Alejandra; Filip, Roxana; Uribarri, Jaime

doi:10.1017/s0954422420000141

Cited by 17 publications

(10 citation statements)

References 129 publications

(184 reference statements)

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“…Coffee consumption has also evidence-based beneficial associations with metabolic diseases (type 2 diabetes, metabolic syndrome, renal stones, and different liver conditions) and neurodegenerative diseases (Parkinson’s and Alzheimer’s disease) [ 2 ]. Therefore, coffee consumption is recommended as part of a healthy diet [ 6 , 7 ], since it contains several bioactive compounds with therapeutic properties [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

et al. 2020

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Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a complex mixture of thousands of bioactive compounds, and some of them have numerous potential health-promoting properties that have been extensively studied in the cardiovascular and central nervous systems, with relatively much less attention given to other body systems, such as the gastrointestinal tract and its particular connection with the brain, known as the brain–gut axis. This narrative review provides an overview of the effect of coffee brew; its by-products; and its components on the gastrointestinal mucosa (mainly involved in permeability, secretion, and proliferation), the neural and non-neural components of the gut wall responsible for its motor function, and the brain–gut axis. Despite in vitro, in vivo, and epidemiological studies having shown that coffee may exert multiple effects on the digestive tract, including antioxidant, anti-inflammatory, and antiproliferative effects on the mucosa, and pro-motility effects on the external muscle layers, much is still surprisingly unknown. Further studies are needed to understand the mechanisms of action of certain health-promoting properties of coffee on the gastrointestinal tract and to transfer this knowledge to the industry to develop functional foods to improve the gastrointestinal and brain–gut axis health.

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Section: Introductionmentioning

confidence: 99%

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

et al. 2020

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“…4c, upper). Western foods that are rich in solid fats, fatty meats, full-fat dairy products, and highly processed foods (mainly grilled, fried, deep fat fried, and roasted dishes) tend to be the richest dietary sources of AGEs [81]. On the other hand, the Japanese diet includes many low-fat foods, such as rice, seaweed, mushrooms, soy-based foods; i.e., tofu, and vegetables (especially root vegetables that are rich in insoluble/ indigestible dietary fiber), and meals with low dietary AGE levels (mainly boiled and steamed dishes) [74].…”

Section: Discussionmentioning

confidence: 99%

“…The liver plays a major role in carbohydrate homeostasis, controlling glucose levels by synthesizing and degrading glycogen and making glucose via gluconeogenesis [80]. The liver is also generally assumed to be the primary site of dietary fructose metabolism, and fructose promotes hepatic lipid accumulation via GA. Western foods that are rich in solid fats, fatty meals, full-fat dairy products, and highly processed foods tend to be the richest dietary sources of AGEs [81]. The thermal treatment of foods might increase their digestibility, nutritional value, and shelf-life.…”

Section: Intracellular Tage Generation and Accumulationmentioning

confidence: 99%

Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle

Takeuchi

2020

Diabetol Metab Syndr

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Background The habitual excessive intake of sugar (i.e., sucrose and high-fructose corn syrup), which has been implicated in the onset of diabetes mellitus, induces excessive production of glyceraldehyde, a metabolite produced during glucose and fructose metabolism, in hepatocytes, neuronal cells, and cardiomyocytes. Main text Toxic advanced glycation end-products (toxic AGEs, TAGE) are formed from reactions between glyceraldehyde and intracellular proteins, and their accumulation contributes to various cellular disorders. TAGE leakage from cells affects the surrounding cells and increases serum TAGE levels, promoting the onset and/or development of lifestyle-related diseases (LSRD). Therefore, serum TAGE levels have potential as a novel biomarker for predicting the onset and/or progression of LSRD, and minimizing the effects of TAGE might help to prevent the onset and/or progression of LSRD. Serum TAGE levels are closely related to LSRD associated with the excessive ingestion of sugar and/or dietary AGEs. Conclusions The TAGE theory is also expected to open new perspectives for research into numerous other diseases.

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“…From the nutritional perspective, strategies for the prevention of CLGI are required to reduce the impacts of several metabolic diseases, as well as to promote healthy aging. A balanced diet is often recommended to maintain good health [ 134 ], and evidence is also emerging from murine models that CLGI may be attenuated through the use of natural products, hinting at the possibility that dietary intervention may have the potential to limit initiation and/or progression of CLGI. Indeed, the use of probiotics or extracts of certain berries has been reported to ameliorate diet-induced CLGI in murine models under HFD [ 135 , 136 , 137 ], though these studies require confirmation in clinical studies in humans.…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

Effect of Advanced Glycation End-Products and Excessive Calorie Intake on Diet-Induced Chronic Low-Grade Inflammation Biomarkers in Murine Models

et al. 2021

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Chronic Low-Grade Inflammation (CLGI) is a non-overt inflammatory state characterized by a continuous activation of inflammation mediators associated with metabolic diseases. It has been linked to the overconsumption of Advanced Glycation End-Products (AGEs), and/or macronutrients which lead to an increase in local and systemic pro-inflammatory biomarkers in humans and animal models. This review provides a summary of research into biomarkers of diet-induced CLGI in murine models, with a focus on AGEs and obesogenic diets, and presents the physiological effects described in the literature. Diet-induced CLGI is associated with metabolic endotoxemia, and/or gut microbiota remodeling in rodents. The mechanisms identified so far are centered on pro-inflammatory axes such as the interaction between AGEs and their main receptor AGEs (RAGE) or increased levels of lipopolysaccharide. The use of murine models has helped to elucidate the local and systemic expression of CLGI mediators. These models have enabled significant advances in identification of diet-induced CLGI biomarkers and resultant physiological effects. Some limitations on the translational (murine → humans) use of biomarkers may arise, but murine models have greatly facilitated the testing of specific dietary components. However, there remains a lack of information at the whole-organism level of organization, as well as a lack of consensus on the best biomarker for use in CLGI studies and recommendations as to future research conclude this review.

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Healthy eating recommendations: good for reducing dietary contribution to the body’s advanced glycation/lipoxidation end products pool?

Cited by 17 publications

References 129 publications

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle

Effect of Advanced Glycation End-Products and Excessive Calorie Intake on Diet-Induced Chronic Low-Grade Inflammation Biomarkers in Murine Models

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