Hearing loss in patients using isotretinoin: is it a side effect or due to hyperlipidemia?

Boztepe, Ozgur

doi:10.2399/jmu.2013002007

Cited by 2 publications

(8 citation statements)

References 17 publications

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“…There are also publications reporting that a low cholesterol diet and antihyperlipidemic treatment improve sudden hearing loss [ 3 , 4 , 19 , 20 ]. In the study of Boztepe et al [ 5 ] conducted with patients with acne vulgaris, it was found that isotretinoin therapy influenced hearing, and triglyceride and cholesterol levels, and that increased blood lipid levels were associated with hearing impairment. The authors concluded that these two effects might occur due to the indirect consequence of a concurrent side effect of the drug and elevated blood lipid levels [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris

Yaldız¹,

Kara²,

Güven³

et al. 2020

pdia

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Introduction: Isotretinoin (13-cis retinoid) is a synthetic retinoid. It was approved by the FDA in 1982 for use of oral isotretinoin in severe acne. It is also used in moderate-severe acne that does not respond to conventional treatments. Isotretinoin is the only available drug that affects all stages of acne pathogenesis. Aim: To prospectively investigate whether there is an effect of isotretinoin therapy on auditory function and, if so, to demonstrate its association with simultaneous blood lipid levels. Material and methods: Thirty patients (60 ears) with acne vulgaris, who received 0.5 mg/kg of isotretinoin therapy, were included in the study. Distortion product otoacoustic emissions (DPOAEs) and pure tone audiometry tests were performed to evaluate auditory function at the beginning of the procedure and the 6 th month of treatment. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol, triglyceride, high-density lipoproteins (HDL) and low-density lipoproteins (LDL) cholesterol levels were recorded. Results: There was no statistically significant difference between pre-treatment and post-treatment mean pure tone audiometry threshold and DPOAE values; however, the increase in total blood cholesterol, triglyceride and LDL levels and the decrease in HDL levels were statistically significant. Conclusions: According to our study findings, isotretinoin did not cause worsening of the bilateral hearing threshold, but increased blood lipid levels. There is no need for follow-up auditory functions in routine practice during therapy, but blood lipid levels should be monitored.

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Section: Discussionmentioning

confidence: 99%

“…There have recently been reports of adverse effects of hyperlipidemia on auditory function [3,4]. In addition, Boztepe et al found a decrease in the pure tone audiometry thresholds at the 6 th month of isotretinoin therapy, and this finding was associated with an increase in triglyceride and total cholesterol levels [5].…”

Section: Introductionmentioning

confidence: 99%

Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris

Yaldız¹,

Kara²,

Güven³

et al. 2020

pdia

View full text Add to dashboard Cite

show abstract

“…Boztepe et al performed a study with 47 acne patients using 0.5 mg/kg isotretinoin and, found that isotretinoin treatment decreased PTAs at the end of the sixth month. They suggested that this might be associated with increased lipid levels, as our results indicated, but in this study also, there were no data about the hearing status of the patients after stopping therapy and whether there was a correlation with hyperlipidemia 11 . Akdağ et al performed a study with 31 acne patients using 0.3‐0.6 mg/kg/day systemic isotretinoin.…”

Section: Discussionmentioning

confidence: 59%

“…We can hypothesize that hearing loss in the patients who received oral isotretinoin might be due to hyperlipidemia as explained previously. 11 Development of hyperlipidemia in the patients who received oral isotretinoin may lead to a decrease in cochlear oxygenation. The other mechanism might be a direct toxicity on the cochlea or a decrease in vascularization.…”

Section: Discussionmentioning

confidence: 99%

“…It greatly reduces sebum production, influences comedogenesis, reduces the colonization of Propionibacterium acnes , and has anti‐inflammatory properties 2‐5 . Various narrative reviews and, studies on acne have discussed the efficacy and adverse events of oral isotretinoin, but studies about the side effects on the hearing system have rarely been reported 3,8‐11 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of oral isotretinoin effects on hearing system in patients with acne vulgaris: Reversible or not?

Kemeriz

Kayabaşı

Cemil

et al. 2020

Dermatologic Therapy

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Systemic isotretinoin is commonly used for severe acne treatment. It has many side effects, one of these is about hearing system, which has rarely been reported, also previous studies reported contradictory results about systemic isotretinoin and its association with hearing system. In this study, we aimed to investigate whether systemic isotretinoin affected on the hearing system or not. The study included 32 acne vulgaris patients (64 ears) who treated with oral isotretinoin 0.5 mg/kg body weight for at least 4 months and audiometric tests including pure‐tone, speech, bilateral acoustic reflexes, and tympanometric measurements were performed at baseline, in the first week, in the first month, and third month of treatment, and sixth month after treatment. Audiometric tests were performed for right and left ears separately. A significant difference was found in the pure‐tone thresholds (before treatment, first week, first month, third month of treatment, and sixth month after treatment) for the both ears at 8000 Hz (P < .001) and a significant decrease in the sixth month post‐treatment pure‐tone thresholds compared to pre‐treatment thresholds at 8000 Hz. Additionally, a statistically significant increase was observed in serum LDL and triglyceride levels in the third month of treatment and a significant decrease at the sixth month after treatment (P < .001). Systemic isotretinoin caused bilateral hearing threshold changes in acne patients during the therapy but the changes improved after discontinuation. Therefore, our findings may provide safety using for dermatologists about hearing effects of isotretinoin, which is quite effective on severe acne.

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Hearing loss in patients using isotretinoin: is it a side effect or due to hyperlipidemia?

Cited by 2 publications

References 17 publications

Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris

Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris

Evaluation of oral isotretinoin effects on hearing system in patients with acne vulgaris: Reversible or not?

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