Hearing loss is associated with hippocampal atrophy and high cortisol/dehydroepiandrosterone sulphate ratio in older adults

Aoki, Mitsuhiro; Okuda, Hiroshi; Ishihara, Hiromasa; Hayashi, Hisamitsu; Ohashi, Toshimitsu; Nishihori, Takesumi; Kuze, Bunya

doi:10.1080/14992027.2020.1831703

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…The hippocampus, which is the limbic system core and is involved in memory formation and sensory processing including auditory information (Diederen et al, 2010), is part of a system for auditory working memory that maintains sounds in memory (Kumar et al, 2016). Moreover, voxel-based MRI analysis has revealed distinct hippocampal atrophy in older adults with ARHL compared with those showing mild-to-normal hearing (Aoki et al, 2020). Ruan et al (2018) reported that withdrawing the cholinergic input to neuropeptide neuroglia from hippocampal cells, mainly under cholinergic regulation, may be involved in the excitation-inhibition imbalance in the central auditory system by affecting GABA release.…”

Section: Discussionmentioning

confidence: 99%

Supplementary Effect of Choline Alfoscerate on Speech Recognition in Patients With Age-Related Hearing Loss: A Prospective Study in 34 Patients (57 Ears)

Kwak

Jang

et al. 2021

Front. Aging Neurosci.

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To investigate the effect of choline alfoscerate (CA) on hearing amplification in patients with age related hearing loss, we performed a prospective case-control observational study from March 2016 to September 2020. We assessed patients with bilateral word recognition score (WRS) <50% using monosyllabic words. The patients were 65–85 years old, without any history of dementia, Alzheimer’s disease, parkinsonism, or depression. After enrollment, all patients started using hearing aids (HA). The CA group received a daily dose of 800 mg CA for 11 months. We performed between-group comparisons of audiological data, including pure tone audiometry, WRS, HA fitting data obtained using real-ear measurement (REM), and the Abbreviated Profile of Hearing Aid benefit scores after treatment. After CA administration, the WRS improved significantly in the CA group (4.2 ± 8.3%), but deteriorated in the control group (−0.6 ± 8.1%, p = 0.035). However, there was no significant between-group difference in the change in pure tone thresholds and aided speech intelligibility index calculated from REM. These findings suggest that the difference in WRS was relevant to central speech understanding rather than peripheral audibility. Therefore, administering oral CA could effectively enrich listening comprehension in older HA users.

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Section: Discussionmentioning

confidence: 99%

Supplementary Effect of Choline Alfoscerate on Speech Recognition in Patients With Age-Related Hearing Loss: A Prospective Study in 34 Patients (57 Ears)

Kwak

Jang

et al. 2021

Front. Aging Neurosci.

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“…In fact, studies have shown that hearing loss is independently associated with atrophy or structural changes in brain areas involved in cognitive function, like the hippocampus ( Belkhiria et al, 2019 ; Chen et al, 2020 ; Croll et al, 2020 ; Xing et al, 2020 ; Aoki et al, 2021 ). For instance, Aoki et al (2021) revealed atrophy of the hippocampus in participants with moderate/severe hearing loss relative to participants with normal hearing or mild hearing loss. Croll et al (2020) reported that hearing loss is linked to lower microstructural integrity in brain areas involved in cognitive processes.…”

Section: Discussionmentioning

confidence: 99%

Hearing loss, hearing aid use, and performance on the Montreal cognitive assessment (MoCA): findings from the HUNT study in Norway

Moradi,

Engdahl,

Johannessen

et al. 2024

Front. Neurosci.

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PurposeTo evaluate the associations between hearing status and hearing aid use and performance on the Montreal Cognitive Assessment (MoCA) in older adults in a cross-sectional study in Norway.MethodsThis study utilized data from the fourth wave of the Trøndelag Health Study (HUNT4, 2017–2019). Hearing thresholds at frequencies of 0.5, 1, 2, and 4 kHz (or PTA4) in the better hearing ear were used to determine participants’ hearing status [normal hearing (PTA4 hearing threshold, ≤ 15 dB), or slight (PTA4, 16–25 dB), mild (PTA4, 26–40 dB), moderate (PTA4, 41–55 dB), or severe (PTA4, ≥ 56 dB) hearing loss]. Both standard scoring and alternate MoCA scoring for people with hearing loss (deleting MoCA items that rely on auditory function) were used in data analysis. The analysis was adjusted for the confounders age, sex, education, and health covariates.ResultsThe pattern of results for the alternate scoring was similar to that for standard scoring. Compared with the normal-hearing group, only individuals with moderate or severe hearing loss performed worse in the MoCA. In addition, people with slight hearing loss performed better in the MoCA than those with moderate or severe hearing loss. Within the hearing loss group, hearing aid use was associated with better performance in the MoCA. No interaction was observed between hearing aid use and participants’ hearing status with performance on the MoCA test.ConclusionWhile hearing loss was associated with poorer performance in the MoCA, hearing aid use was found to be associated with better performance in the MoCA. Future randomized control trials are needed to further examine the efficacy of hearing aid use on the MoCA performance. When compared with standard scoring, the alternate MoCA scoring had no effect on the pattern of results.

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“…Tang et al reported that middle-aged adults with acquired sensorineural hearing loss had higher levels of depression and anxiety and lower functional connectivity between the amygdala and auditory cortex, striatum, multimodal processing areas, and fronto-parietal control areas compared with normal-hearing peers ( 61 ). Aoki et al ( 62 ) found that moderate/severe hearing loss was associated with higher depression scores in older adults, hippocampal atrophy and a higher cortisol/dehydroepiandrosterone sulfate ratio, which indicates higher stress levels ( 62 ). Brewster et al examined older people with untreated hearing loss and major depression according to DSM 5 (Diagnostic and Statistical Manual) ( 63 , 64 ).…”

Section: Introductionmentioning

confidence: 99%

Hearing loss, depression, and cognition in younger and older adult CI candidates

Huber,

Reuter,

Weitgasser

et al. 2023

Front. Neurol.

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Background and AimHearing loss in old age is associated with cognitive decline and with depression. Our study aimed to investigate the relationship between hearing loss, cognitive decline, and secondary depressive symptoms in a sample of younger and older cochlear implant candidates with profound to severe hearing loss.MethodsThis study is part of a larger cohort study designated to provide information on baseline data before CI. Sixty-one cochlear implant candidates with hearing loss from adulthood onwards (>18 years) were enrolled in this study. All had symmetrical sensorineural hearing loss in both ears (four-frequency hearing threshold difference of no more than 20 dB, PTA). Individuals with primary affective disorders, psychosis, below-average intelligence, poor German language skills, visual impairment, and a medical diagnosis with potential impact on cognition (e.g., neurodegenerative diseases,) were excluded. Four-frequency hearing thresholds (dB, PTA, better ear) were collected. Using the Abbreviated Profile of Hearing Aid Benefit, we assessed subjective hearing in noise. Clinical and subclinical depressive symptoms were assessed with the Beck Depression Inventory (BDI II). Cognitive status was assessed with a neurocognitive test battery.ResultsOur findings revealed a significant negative association between subjective hearing in noise (APHAB subscale “Background Noise”) and BDII. However, we did not observe any link between hearing thresholds, depression, and cognition. Additionally, no differences emerged between younger (25–54 years) and older subjects (55–75 years). Unexpectedly, further unplanned analyses unveiled correlations between subjective hearing in quiet environments (APHAB) and cognitive performance [phonemic fluency (Regensburg Word Fluency), cognitive flexibility (TMTB), and nonverbal episodic memory (Nonverbal Learning Test), as well as subjective hearing of aversive/loud sounds (APHAB)], cognitive performance [semantic word fluency (RWT), and inhibition (Go/Nogo) and depression]. Duration of hearing loss and speech recognition at quiet (Freiburg Monosyllables) were not related to depression and cognitive performance.ConclusionImpact of hearing loss on mood and cognition appears to be independent, suggesting a relationship with distinct aspects of hearing loss. These results underscore the importance of considering not only conventional audiometric measures like hearing thresholds but also variables related to hearing abilities during verbal communication in everyday life, both in quiet and noisy settings.

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Hearing loss is associated with hippocampal atrophy and high cortisol/dehydroepiandrosterone sulphate ratio in older adults

Cited by 6 publications

References 40 publications

Supplementary Effect of Choline Alfoscerate on Speech Recognition in Patients With Age-Related Hearing Loss: A Prospective Study in 34 Patients (57 Ears)

Supplementary Effect of Choline Alfoscerate on Speech Recognition in Patients With Age-Related Hearing Loss: A Prospective Study in 34 Patients (57 Ears)

Hearing loss, hearing aid use, and performance on the Montreal cognitive assessment (MoCA): findings from the HUNT study in Norway

Hearing loss, depression, and cognition in younger and older adult CI candidates

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