Professional road cycling is an extreme endurance sport. Approximately 30,000-35,000 km are cycled each year and the racing season of professional riders includes ϳ90 competition days. In addition, despite the long duration of cycling events such as 3-week stage races, the relative contribution of intense exercise is surprisingly high during the more physically taxing events (mountain passes, time trials, sprints, "breakaways" etc.) [1].Several investigators have analyzed a number of physiological variables in professional cyclists, both in laboratory [2][3][4][5][6][7] and field settings [1,[8][9][10]. However, no prospective, long-term investigation has established the specific physiological adaptations which occur in professional cyclists as a response to training and competition during a typical sports season (generally including different periods in terms of training volume and/or intensity; i.e., precompetition or training, competition, and postcompetition or "active" rest periods). In a recent study (unpublished data), we found no overall training-effect on the ventilatory response (i.e., pulmonary ventilation, tidal volume, ventilatory equivalents, "timing" of respiration, etc.) in the same 13 subjects who formed the present study population. It was therefore considered of interest to extend this investigation to determine whether meta- ]. Finally, rms-EMG tended to increase during the season, with significant differences (pϽ0.05) observed mainly between the competition and rest periods at most workloads. In contrast, precompetition MPF values increased (pϽ0.05) with respect to resting values at most submaximal workloads but fell (pϽ0.05) during the competition period. Our findings suggest that endurance conditioning induces the following general adaptations in elite athletes: (1) lower circulating lactate and increased reliance on aerobic metabolism at a given submaximal intensity, and possibly (2) an enhanced recruitment of motor units in active muscles, as suggested by rms-EMG data.