Heart Failure and Hospital Utilization Trajectories Before and After Hip Fracture Surgery

Wei, Sijia; Pan, Wei; Lee, Chiyoung; Tsumura, Hideyo; Xue, Tingzhong; McConnell, Eleanor S.

doi:10.1016/j.jamda.2022.05.015

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…MACE is one of the most common postoperative complications of hip fracture repair surgery, which significantly affects the recovery of patients [ 10 , 19 ]. A previous study reported that the occurrence of heart failure in elderly patients who received hip fracture repair surgery reached up to 16% [ 20 , 21 ]. However, another study found that the occurrence of MACE was 12% in elderly hip fracture patients [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Increasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery

Sun,

Cheng,

Jin

et al. 2023

BMC Musculoskelet Disord

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Background Major adverse cardiovascular events (MACE) are critical complications responsible for the morbidity and mortality of elderly hip fracture patients. There was an urgent need to explore an effect biomarker for predicting MACE in elderly patients receiving hip fracture surgery. Objective This study focused on an age-related miRNA, miR-409-3p, and assessed its significance in elderly hip fracture patients. Methods A total of 267 hip fracture patients were enrolled in this study including 104 elderly patients (age ≥ 60 years). All patients were followed up for 1 year to monitor the occurrence of MACE. The risk factors for the occurrence of MACE were evaluated by the logistic regression analysis. Results Elderly age and reduced cardiac and renal function were identified as risk factors for MACE in hip fracture patients. Elderly patients also showed a high incidence of MACE. In elderly hip fracture patients, significant upregulation of miR-409-3p was observed, which was associated with patients’ elderly age, higher level of revised cardiac risk index (RCRI), lower left ventricular ejection fraction (LVEF), and higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase-MB (CK-MB), and high sensitivity troponin I (hsTnI). Additionally, miR-409-3p was identified as an independent factor for the MACE in elderly patients received hip fracture surgery. Conclusion Upregulated miR-409-3p was an age-related miRNA and could predict the occurrence of MACE in elderly hip fracture patients.

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Section: Discussionmentioning

confidence: 99%

Increasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery

Sun,

Cheng,

Jin

et al. 2023

BMC Musculoskelet Disord

View full text Add to dashboard Cite

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Characterizing hospitalization trajectories in the high-need, high-cost population using electronic health record data

Lee,

French,

Balucan

et al. 2023

Health Affairs Scholar

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High utilization by a minority of patients accounts for a large share of health care costs, but the dynamics of this utilization remain poorly understood. We sought to characterize longitudinal trajectories of hospitalization among adult patients at an academic medical center from 2017 to 2023. Among 3404 patients meeting eligibility criteria, following an initial “rising-risk” period of 3 hospitalizations in 6 months, growth mixture modeling discerned 4 clusters of subsequent hospitalization trajectories: no further utilization, low chronic utilization, persistently high utilization with a slow rate of increase, and persistently high utilization with a fast rate of increase. Baseline factors associated with higher-order hospitalization trajectories included admission to a nonsurgical service, full code status, intensive care unit-level care, opioid administration, discharge home, and comorbid cardiovascular disease, end-stage kidney or liver disease, or cancer. Characterizing hospitalization trajectories and their correlates in this manner lays groundwork for early identification of those most likely to become high-need, high-cost patients.

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Heart Failure and Hospital Utilization Trajectories Before and After Hip Fracture Surgery

Cited by 2 publications

References 7 publications

Increasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery

Increasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery

Characterizing hospitalization trajectories in the high-need, high-cost population using electronic health record data

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